Peptic Ulcer Disease (PUD), Diagnosis, and Current Medication-Based Management Options: Schematic Overview

Srivastav, Yash; Kumar, Vijay; Srivastava, Yashi; Kumar, Madhaw

doi:10.9734/jamps/2023/v25i11651

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Gastric ulcers, common in peptic ulcer disease, occur due to an imbalance between mucosal defense and aggressive factors like acid and pepsin and are caused by various factors, including Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs (NSAIDs), stress, smoking, and genetics. 1 The pathogenesis of gastric ulcers involves disrupted mucosal defense, increased gastric acid secretion, and impaired epithelial repair mechanisms. 2 Indomethacin (INDO), an NSAID, is known to inflict more significant damage on the gastric mucosa in rats than other similar medications.…”

Section: Introductionmentioning

confidence: 99%

Laurus nobilis Esansiyel Yağının Sıçanlarda İndometasin Kaynaklı Mide Ülserinin Azaltılmasında Potansiyel Rolü

ÜSTÜNDAĞ,

TAŞ,

KURT

et al. 2024

Online Türk Sağlık Bilimleri Dergisi

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Objective: This study aimed to investigate the gastroprotective effects of Laurus nobilis leaves essential oil (LANO) against indomethacin (INDO)-induced gastric ulcers in rats. Materials and Methods: In this study, an indomethacin-induced gastric ulcer model was employed. 30 Sprague-Dawley rats were divided into five groups (n=6): Control, LANO, INDO, INDO with famotidine (FAM), and INDO with LANO. Indomethacin (25 mg/kg) induced ulcers, while LANO and FAM were administered by oral gavage at 200 mg/kg and 40 mg/kg, respectively. Gastric tissues underwent histopathological examination for ulceration, and biochemical assays measured total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and nitric oxide (NO) levels. Results: Compared to the INDO group, treatment with LANO significantly decreased the number of gastric ulcer foci. Biochemically, LANO moderated TOS and OSI levels and preserved TAS, indicating reduced oxidative stress. Additionally, LANO appeared to stabilize NO levels. These biochemical findings were corroborated by histopathological examination. Conclusions: The study's results indicate that LANO may be beneficial in protecting against NSAID-induced gastric damage. LANO's observed modulation of oxidative stress markers and NO levels suggests its potential role in managing gastric ulcers.

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Section: Introductionmentioning

confidence: 99%

Laurus nobilis Esansiyel Yağının Sıçanlarda İndometasin Kaynaklı Mide Ülserinin Azaltılmasında Potansiyel Rolü

ÜSTÜNDAĞ,

TAŞ,

KURT

et al. 2024

Online Türk Sağlık Bilimleri Dergisi

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Phytochemistry and Biological Activities of Ethnopharmacological Plants Widely Used in the Treatment of Pectic Ulcer Diseases

Ibrahim,

Salisu,

Gambo

et al. 2024

UJMR

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Study’s Novelty/Excerpt This review systematically explores the anti-ulcerogenic potential of medicinal plants, emphasizing their bioactive compounds and pharmacological properties, a topic underexplored in the context of peptic ulcer management. The inclusion of 33 studies from 2010-2024 offers a comprehensive analysis of plant species like Curcuma longa, Moringa oleifera, and Allium sativum, highlighting their multiple mechanisms of action, including anti-inflammatory and anti-H. pylori effects. The findings highlights the potential of these ethnobotanical resources to complement or replace synthetic drugs, addressing the growing need for safer and more effective peptic ulcer treatments. Full Abstract The common gastrointestinal ailment known as peptic ulcer is characterized by damage to the stomach and duodenum's mucosal integrity, mostly as a result of an unbalanced interaction between mucus production and other defensive systems and aggressive elements like gastric acid. Pain, loss of appetite, bloating, nausea, perforations, weight loss, bloody stools, or vomiting are some of the signs that identify the condition. The necessity for efficient treatment plans is highlighted by the rising incidence of peptic ulcers, which is made worse by conditions including Helicobacter pylori infection and NSAID use. Herbal drugs are emerging as alternative remedies for various health conditions. With an emphasis on the bioactive chemicals and pharmacological properties of these plants, this review investigates the therapeutic potential of medicinal plants in the management of peptic ulcers. A PRISMA-compliant systematic review was carried out to evaluate the anti-ulcerogenic qualities of a variety of medicinal plants. We looked through scientific databases, including PubMed, Scopus, and Google Scholar, to find pertinent research that was published between 2010 and 2024. Terms like "peptic ulcer," "anti-ulcer plants," "plant-derived drugs for peptic ulcer," "herbal drugs," and "phytomedicine for peptic ulcer" were used in the search. Thirty-three (33) full-text articles out of 2,650 entries that were examined and found to match the inclusion criteria were included. Plant species, bioactive chemicals, and their proven effects on peptic ulcers in preclinical research were the main topics of data extraction. This review highlights the many modes of action and therapeutic applications of the several medicinal plant extracts that have been connected to anti-ulcer properties. The ethnobotanical plants were discovered to be a rich source of phytochemicals, including flavonoids, alkaloids, tannins, simple phenols, and saponins. Numerous therapeutic plants with potent anti-ulcerogenic, anti-inflammatory, and antibacterial qualities have been found to exist, such as Curcuma longa, Moringa oleifera, and Allium sativum. These plants improve mucosal defence systems, lower stomach acid output, control inflammatory mediators, and inhibit H. pylori, offering considerable therapeutic potential. More research is required to fully understand the medical potential of these natural medicines, as the findings show that they can successfully complement current treatments for peptic ulcers, lowering dependency on synthetic pharmaceuticals and minimizing associated adverse effects.

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Peptic Ulcer Disease (PUD), Diagnosis, and Current Medication-Based Management Options: Schematic Overview

Cited by 2 publications

References 52 publications

Laurus nobilis Esansiyel Yağının Sıçanlarda İndometasin Kaynaklı Mide Ülserinin Azaltılmasında Potansiyel Rolü

Laurus nobilis Esansiyel Yağının Sıçanlarda İndometasin Kaynaklı Mide Ülserinin Azaltılmasında Potansiyel Rolü

Phytochemistry and Biological Activities of Ethnopharmacological Plants Widely Used in the Treatment of Pectic Ulcer Diseases

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