Peptic ulcer disease following transplantation: The role of cimetidine

Garvin, Paul J.; Carney, Kathleen; Castañeda, Marco A.; Codd, John E.

doi:10.1016/0002-9610(82)90577-3

Cited by 18 publications

(6 citation statements)

References 15 publications

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“…In such retrospective studies Jones et al and Roermund et al found a significant effect of cimetidine7 8 and Garvin et al reported some effect. 9 In the only prospective study reported Schiessel et al found no significant effect of cimetidine after renal transplantation in 55 patients. 10 Primack suggested that treatment with cimetidine might increase the incidence of allograft rejection.…”

Section: Discussionmentioning

confidence: 93%

Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests.

LaFerla¹,

Murray²

1984

BMJ

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Section: Discussionmentioning

confidence: 93%

Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests.

LaFerla¹,

Murray²

1984

BMJ

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“…The 4.7 % complication rate decreased to 0.8% after the systematic use of an H2 receptor antagonist. In Garvin et al's study [12], the prophylactic use of antacids plus an H2 receptor antagonist reduced mortality from 22 YO to 0 YO. We believe that the introduction of cyclosporin and consecutive steroid reduction, associated with preventive H2 receptor antagonist, helped to significantly lower the mortality rate due to gastroduodenal ulcers; this mortality reached SO % in previous historical publications [ 14, 221.…”

Section: Discussionmentioning

confidence: 95%

Gastrointestinal complications in renal transplantation

et al. 1993

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One wonders whether the use of cyclosporin, histamine receptor antagonists, low doses of steroids, and early diagnosis and treatment actually modify the incidence, morbidity, and mortality of gastrointestinal (GI) and pancreatic complications in renal transplantation. To find out, we reviewed 614 kidney transplant recipients between January 1984 and December 1988. One hundred patients (16.2%) were found to have GI and/or pancreatic complications in the following distribution: 9.6% gastroduodenal, 1.3% pancreatic, 4% colonic, and 0.4% small bowel. None of the patients presenting a gastroduodenal ulcer had perforation or bleeding. Fifty-five percent of the patients with this complication had a past history of eso-gastroduodenal disease, compared to 19.6% in recipients without gastroduodenal complications. Some 4.4% of the patients had a small bowel or a colonic complication and four died of peritonitis due to bowel perforation. Mortality was 35% in those having intestinal resection and/or perforation with peritonitis. Sixteen percent of patients with colonic complications had a known history of diverticula, compared to 3% for those without colonic complications. The incidence of GI and/or pancreatic complications in renal transplant recipients remains high and has caused 1.1% of the deaths in our series. Mortality is essentially due to upper GI bleeding, peritonitis following perforation, and infectious colitis. Better detection of gastroduodenal and colonic disease before transplantation seems to be mandatory. Prevention with histamine H2 receptor antagonists and early surgical treatment of complicated colonic diverticula help to reduce the morbidity and mortality in kidney graft recipients.

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“…Approximately 25% of these patients required laparotomy and 50% died (1–6). The 1980s saw the frequency of complications drop to 7%, although the laparotomy and mortality rates in these patients remained around the same level (9–15). Publications in the 1990s have indicated a 6% prevalence of foregut complications, laparotomy and mortality rates in the patients with complications being <5% in most series (16–21).…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal complications after renal transplantation: a 3‐yr sequential study

Logan

Morris‐Stiff

Bowrey

et al. 2002

Clinical Transplantation

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We observed a low frequency (8%) of upper gastrointestinal tract complications after renal transplantation. There was no difference in the frequency of complications between patients on tacrolimus and those on cyclosporin based immunosuppression. Furthermore, the complication rates were similar in those that received omeprazole and those that received ranitidine as antiulcer prophylaxis, indicating the equivalence of these two agents in this setting.

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Peptic ulcer disease following transplantation: The role of cimetidine

Cited by 18 publications

References 15 publications

Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests.

Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests.

Gastrointestinal complications in renal transplantation

Upper gastrointestinal complications after renal transplantation: a 3‐yr sequential study

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