Peptic ulcer disease

Sverdén, Emma; Agréus, Lars; Dunn, Jason M.; Lagergren, Jesper

doi:10.1136/bmj.l5495

Cited by 67 publications

(56 citation statements)

References 78 publications

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“…According to Sverdén et al (2019), Peptic ulcer disease (PUD) is frequently characterized as a tissue layer break more prominent than 3-5 metric linear unit within the abdomen or small intestine with a comprehensible profundity. Peptic ulcer illness presents with gastrointestinal indications like indigestion and can be hard to recognize clinically.…”

Section: The Role Of H Pylori In Peptic Ulcermentioning

confidence: 99%

An Overview of Helicobacter Pylori Infection and Its Mystery

Attah¹,

Mela²,

D.E³

et al. 2020

IJRP

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Helicobacter pylori (H. pylori) is a gram negative microaerophilic bacterium that infects the epithelial lining of the stomach and is associated with the development of peptic ulcers and cancer. Infection is more common in those with a lower socioeconomic status and is commonly acquired during infancy. There is no recognized route of infection, but fecal-oral and oral-oral contact has been associated with transmission from person to individual. There were no clinical signs in several individuals harboring the pathogens. The only viable bacterium that survived the acidic existence of the stomach due to the capacity of the organism to generate urease and other adaptive factors is Helicobacter pylori. A specific virulence factor affecting colonization and disease severity has been recognized: cytotoxin-associated (cagA) and vacuolating cytotoxin (vacA). The most recognized risk factor for peptic ulcer disease and gastric cancer is Helicobacter pylori. As a result of its resistance to antibiotics and false understanding of the infection by people, the burden of helicobacter pylori infection aggravated. Invasive and non-invasive approaches is used to detect it. Prevention of the organism is strictly by observation of proper hygiene and awareness. The endemicity of Helicobacter pylori call for early detection to avert the health implications.

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Section: The Role Of H Pylori In Peptic Ulcermentioning

confidence: 99%

An Overview of Helicobacter Pylori Infection and Its Mystery

Attah¹,

Mela²,

D.E³

et al. 2020

IJRP

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“…Peptic ulcer disease refers a mucosal break deeper than 3–5 mm in the duodenum or stomach. 1 It is mainly due to the imbalance of protective and injury factors between gastric mucosa and duodenum. Gastric ulcer and duodenal ulcer are similar in appearance, often accompanied by upper or posterior sternum pain, early satiety, nausea, bloating, or post-meal pain.…”

Section: Introductionmentioning

confidence: 99%

The role of nitric oxide in peptic ulcer: a narrative review

Liang

Deng

et al. 2021

Med Gas Res

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Peptic ulcer refers to the inflammatory response and necrotic lesions of the mucosa under the action of various pathogenic factors, which goes deeply into the mucosal muscle layer and often occurs to the gastrointestinal mucosa related to gastric acid secretion, among which the stomach and duodenum are the most common. The clinical manifestations include slow onset, prolonged course and weekly upper abdominal pain. Nitric oxide (NO) is an intracellular and intercellular signaling molecule that plays an important role in many physiological and pathological processes. Studies have found that a small amount of NO produced in vivo plays a role in many physiological homeostasis, such as regulating blood pressure, platelet aggregation, nitrogenization of hemoglobin, and regulating proliferation and differentiation of stem cells. However, under the action of some cytokines and oxidative stress, intracellular NO synthase will catalyze the synthesis of large amounts of NO and participate in the inflammatory response, causing beneficial or harmful effect on the body. Numerous basic studies have focused on the relationship between NO and peptic ulcer. The purpose of this review is to summarize the role of NO in peptic ulcer and its possible mechanism.

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“…This condition is characterized by discontinuation in the stomach mucosa lining because of gastric acid or pepsin secretion induced by different types of triggers. Although this disorder has various causes, Helicobacter pylori and non-steroidal anti-inflammatory drugs account for the majority of the disease etiology [ 4 , 5 , 6 ]. Gastric ulcer disease has decreased significantly but has not disappeared.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation

Vera

Mariani

Aguilera

et al. 2021

IJMS

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The aim of this study was to determine whether the lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one, would be effective in an animal model of gastric ulcer induced by mast cell activation. Rats were divided into ten groups. Treatments were repeated for four days. The degree of gastric erosion was assessed with a scoring system and histological preparations. Gastric mast cell morphology was analyzed by histological procedures. Serum serotonin levels were determined as markers of mast cell activation. Statistical analyses were done using ANOVA and Tukey–Kramer test. We demonstrated that the repeated administration of compound 48/80 results in extensive mucosal lesions in the gastric mucosa and that such lesions occurred in association with mast cell degranulation and a significant increase of serum serotonin. We showed that these lesions were prevented by dehydroleucodine, xanthatin, and 3-benzyloxymethyl-5H-furan-2-one and that this effect was similar to that obtained with sodium cromoglycate. In conclusion, the results of the present study indicate that the optimal gastric cytoprotective dose of dehydroleucodine, xanthatin, and 3-benzyloxymethyl-5H-furan-2-one is efficacious in an animal model of gastric ulcer induced by mast cell activation. Our findings suggest that these lactones could be valuable tools for designing novel therapeutic agents for digestive disorders associated with inappropriate mast cell activation.

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Peptic ulcer disease

Cited by 67 publications

References 78 publications

An Overview of Helicobacter Pylori Infection and Its Mystery

An Overview of Helicobacter Pylori Infection and Its Mystery

The role of nitric oxide in peptic ulcer: a narrative review

Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation

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