Pepsinogens: new variant and linkage relationships to chromosome 6 markers

Gedde‐Dahl, T.; Korsnes, L.; Thorsby, E.; Olaisen, B.; Bratlie, A.; Siverts, A.

doi:10.1159/000130959

Cited by 9 publications

(3 citation statements)

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“…Apart from preliminary reports on part of our families (Gedde-Dahl et al 1978), this is the first study to provide information on the Pg5-PGM, relation. Here again we have excluded linkage up to 8 = 0.22 (lods -2.17) for males and up to 8 = 0.27 ( -2.07) for sexes combined.…”

Section: Colton Diab Esd Gm Gpt Km Pgm Pi and T F ) Have Not mentioning

confidence: 99%

Genetic linkage relation of the pepsinogen Pg5 locus

Korsnes

Olaisen

Thorsby

et al. 1980

Annals of Human Genetics

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Linkage relations between pepsinogen Pg5 and 28 genetic marker loci have been analyzed in Norwegian families. No strong hint of linkage was found. Linkage to Pg5 in males has been ruled out below 25% recombination for HLA and GPT, below 20% recombination for Rh, PGM1, ACP, Gc, MNSs, PGM3, and Gm and Pi, below 15% recombination for Hp, below 10% recombination for Fy, ABO, C3 and Jk and below 4% for Kell, Tf, C6, Km and Le(Se). Possibilities of loose linkages include Pg5-C6 and Pg5-MNSs, both of which should be followed up.

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Section: Colton Diab Esd Gm Gpt Km Pgm Pi and T F ) Have Not mentioning

confidence: 99%

Genetic linkage relation of the pepsinogen Pg5 locus

Korsnes

Olaisen

Thorsby

et al. 1980

Annals of Human Genetics

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“…Weitkamp et al [49] reported that the electrophoretic mobility of urinary pepsinogen was polymorphic in human beings and the locus has been linked to the HLA of the human major histocompatibility complex (MHC), and Gedde-Dahl et al [18] have suggested that the Pg locus might be located on the terminal part of the short arm of chromosome 6. Szymura and Klein [45,461 reported that urinary pepsinogen (UPG-1) in mice was also polymorphic among the laboratory mice and the gene was closely linked to the H-2 of mouse MHC (6 cM), while the Upg-2 locus was located on chromosome 1 [47].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Biochemical Marker Loci Detected with Urine, Tears, and Saliva of Rats

Kondo

1994

Experimental Animals

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“…[81 reported that electrophoretic mobility of urinary pepsinogen was polymorphic in human being and the locus has been linked to the HLA of human major histocompatibility complex (MHC), and Gedde-Dahl et al [3] have suggested that the Pg locus might be located on the terminal part of the short arm of chromosome 6. On the other hand, Szymura and Klein [7] reported that urinary pepsinogen (UPG-1) in mice was also polymorphic among laboratory mice and closely linked to the H -2 of mouse MHC (6 cM).…”

mentioning

confidence: 99%