Pepsin as a biomarker for self-diagnosing reflux associated symptoms in UK and USA individuals

Boulton, Katie H. A.; Fisher, Jeanine; Woodcock, Andrew D.; Dettmar, Peter W.

doi:10.21037/aoe-20-79

Cited by 4 publications

(2 citation statements)

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“…Compared to other diagnostic modalities, this approach is timee cient and requires much less effort. 119 Moreover, pepsin measurements can identify pathologic re ux even in the absence of symptoms, and remain unaffected by the concurrent use of PPI. Several studies have demonstrated that pepsin detection in the sputum and/or saliva can be regarded as a sensitive, non-invasive method for the diagnosis of the proximal re ux of gastric contents, with a sensitivity ranged from 41.5-73% and high speci city of 86.2 to 98.2%.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN): a Case-Control Observational Study Protocol

Javed,

Podury,

Kwon

et al. 2024

Preprint

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BACKGROUND. Particulate matter exposure (PM) is a cause of aerodigestive disease globally. The destruction of the World Trade Center (WTC) exposed first responders and inhabitants of New York City to WTC-PM and caused obstructive airways disease (OAD), gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE). GERD not only diminishes health-related quality of life but also gives rise to complications that extend beyond the scope of BE. GERD can incite or exacerbate allergies, sinusitis, bronchitis, and asthma. Disease features of the aerodigestive axis can overlap, often necessitating more invasive diagnostic testing and treatment modalities. This presents a need to develop novel non-invasive biomarkers of GERD, BE, airway hyperreactivity (AHR), treatment efficacy, and severity of symptoms. METHODS. Our observational case-cohort study will leverage the longitudinally phenotyped Fire Department of New York (FDNY)-WTC exposed cohort to identify Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN). Our study population consists of n = 4,192 individuals from which we have randomly selected a sub-cohort control group (n = 837). We will then recruit subgroups of i. AHR only ii. GERD only iii. BE iv. GERD/BE and AHR overlap or v. No GERD or AHR, from the sub-cohort control group. We will then phenotype and examine non-invasive biomarkers of these subgroups to identify under-diagnosis and/or treatment efficacy. The findings may further contribute to the development of future biologically plausible therapies, ultimately enhance patient care and quality of life. DISCUSSION. Although many studies have suggested interdependence between airway and digestive diseases, the causative factors and specific mechanisms remain unclear. The detection of the disease is further complicated by the invasiveness of conventional GERD diagnosis procedures and the limited availability of disease-specific biomarkers. The management of reflux is important, as it directly increases risk of cancer and negatively impacts quality of life. Therefore, it is vital to develop novel noninvasive disease markers that can effectively phenotype, facilitate early diagnosis of premalignant disease and identify potential therapeutic targets to improve patient care. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05216133; January 18, 2022.

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Section: Discussionmentioning

confidence: 99%

Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN): a Case-Control Observational Study Protocol

Javed,

Podury,

Kwon

et al. 2024

Preprint

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“…Pada mahasiswa, penyakit refluks gastroesofageal (GERD) dapat berdampak pada kualitas hidup, termasuk dalam aspek kinerja akademik (1). Secara global, diperkirakan bahwa sekitar 20% dari seluruh penduduk dunia mengalami penyakit refluks gastroesofageal (GERD) (2). Berdasarkan data Global Burden of Diseases (GBD) pada tahun 2019, jumlah kasus penyakit refluks gastroesofageal (GERD) secara global diperkirakan mencapai sekitar 783,95 juta (3).…”

Section: Pendahuluanunclassified

Hubungan Gastroesophageal Reflux Disease (GERD) dengan Konsentrasi Belajar Mahasiswa Angkatan 2021

Ida Royani,

Khusnul Syafitri,

Pratiwi Nasir Hamzah

et al. 2024

fmj

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Gastroesophageal Reflux Disease (GERD) merujuk pada kondisi refluks isi lambung ke esofagus, yang dapat menimbulkan gejala khas seperti heartburn (sensasi terbakar di daerah epigastrium), regurgitasi asam (rasa pahit di mulut), mual, dan disfagia. Stres diketahui sebagai faktor risiko GERD karena dapat mengakibatkan gangguan pada saluran pencernaan. Mahasiswa kedokteran, khususnya yang tergabung dalam angkatan 2021 di Fakultas Kedokteran Universitas Muslim Indonesia (FK UMI), menghadapi tingkat stres yang lebih tinggi dibandingkan dengan masyarakat umum. Hal ini disebabkan oleh tuntutan beban akademik seperti jadwal perkuliahan yang padat, seringnya ujian dan tugas kuliah, serta kurangnya waktu istirahat yang memadai. Penelitian ini bertujuan untuk mengeksplorasi hubungan antara Gastroesophageal Reflux Disease (GERD) dan konsentrasi belajar pada mahasiswa tahap akademik FK UMI Angkatan 2021. Metode yang digunakan adalah deskriptif analitik dengan pendekatan cross-sectional, dan pengambilan sampel dilakukan secara purposive sampling. Hasil analisis bivariat antara GERD dan konsentrasi belajar menunjukkan nilai p = 0,029 (P < 0,05), menunjukkan adanya hubungan antara Gastroesophageal Reflux Disease dengan tingkat konsentrasi belajar pada mahasiswa FK UMI Angkatan 2021.

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Pepsin in saliva for the diagnosis of erosive esophagitis post-sleeve gastrectomy: a prospective observational study

et al. 2023

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Pepsin as a biomarker for self-diagnosing reflux associated symptoms in UK and USA individuals

Cited by 4 publications

References 0 publications

Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN): a Case-Control Observational Study Protocol

Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN): a Case-Control Observational Study Protocol

Hubungan Gastroesophageal Reflux Disease (GERD) dengan Konsentrasi Belajar Mahasiswa Angkatan 2021

Pepsin in saliva for the diagnosis of erosive esophagitis post-sleeve gastrectomy: a prospective observational study

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