PepPre: Promote Peptide Identification Using Accurate and Comprehensive Precursors
Ching Tarn,
Yu-Zhuo Wu,
Kai-Fei Wang
Abstract:Accurate and comprehensive peptide precursor ions are crucial to tandem mass-spectrometry-based peptide identification. An identification engine can derive great advantages from the search space reduction enabled by credible and detailed precursors. Furthermore, by considering multiple precursors per spectrum, both the number of identifications and the spectrum explainability can be substantially improved. Here, we introduce PepPre, which detects precursors by decomposing peaks into multiple isotope clusters u… Show more
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