Peppermint Oil to Reduce Colonic Spasm During Endoscopy

Leicester, R. J.; Hunt, R H

doi:10.1016/s0140-6736(82)90191-x

Cited by 68 publications

(38 citation statements)

References 3 publications

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“…Our observations that much of the peppermint oil, a natural carminative contained in Colpermin, is released in the colon, plus the previous findings that peppermint oil directly instilled into the colon of man reduces colonic spasm (Leicester & Hunt, 1982) and reduces colonic motility (Duthie, 1981), supports the small clinical study of Rees et al (1979) that Colpermin is useful in the treatment of the irritable bowel/spastic colon syndrome.…”

Section: Discussionsupporting

confidence: 81%

“…When injected directly into the large intestine during colonoscopy peppermint oil reduces colonic spasm induced by the procedure (Leicester & Hunt, 1982) and reduces colonic motility (Duthie, 1981). However, topical pharmacological effects, when taken orally, such as relaxation of the lower oesophageal sphincter (Sigmund & McNally, 1969) are predominantly upper gastrointestinal; menthol and other plant monoterpenes in peppermint oil are rapidly absorbed from the proximal gut.…”

Section: Introduction Methodsmentioning

confidence: 99%

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Delayed release peppermint oil capsules (Colpermin) for the spastic colon syndrome: a pharmacokinetic study.

Somerville¹,

Cr²,

Bell³

1984

Brit J Clinical Pharma

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Excretion of menthol (as glucuronide) from orally ingested peppermint oil contained in Colpermin was compared with oil contained in two soft gelatine capsules. Total 24 h urinary excretion of menthol was similar in the two formulations in healthy volunteers, but peak menthol excretion levels were lower and excretion delayed with Colpermin. Menthol excretion was reduced in ileostomy patients who took Colpermin and moderate amounts of unmetabolised menthol were recovered from the ileostomy effluent. This is consistent with Colpermin being a delayed‐ release form of peppermint oil.

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Section: Discussionsupporting

confidence: 81%

Section: Introduction Methodsmentioning

confidence: 99%

Delayed release peppermint oil capsules (Colpermin) for the spastic colon syndrome: a pharmacokinetic study.

Somerville¹,

Cr²,

Bell³

1984

Brit J Clinical Pharma

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“…Peppermint oil has been used for many years in herbal remedies for the treatment of digestive disorders and it has been shown to be effective in the symptomatic treatment of irritable bowel syndrome (Rees et a1 1979), and to reduce colonic spasm when injected directly into the large intestine during colonoscopy (Leicester & Hunt 1982). When used for the treatment of irritable bowel syndrome, peppermint oil is recommended to be taken in enteric-coated capsules as release of the oil in the stomach causes relaxation of the lower oesophageal sphincter and heart burn (Somerville et a1 1984).…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Menthol and Related Cooling Compounds

Eccles

1994

Journal of Pharmacy and Pharmacology

421

334

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ToxicologySummary-Menthol and related cooling compounds such as 'coolant agent lo', are widely used in products ranging from common cold medications to toothpastes, confectionery, cosmetics and pesticides. The review brings together a range of information on production and chemistry of menthol, and its metabolism, mechanism of action, structure-activity relationships, pharmacology and toxicology. In particular, the coolant action and carminative actions of menthol are discussed in terms of actions on calcium conductance in sensory nerves and smooth muscle. The actions of menthol on the nose, respiratory reflexes, oral cavity, skin and gastrointestinal tract are reviewed.

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“…Peppermint oil has been demonstrated to be a useful antispasmodic agent for upper GI endoscopy [9], colonoscopy [10,11], and barium enema examination [12,13]. Recently, we reported that topical treatment with L-menthol, the major constituent of peppermint oil, effectively suppressed gastric peristalsis in a multicenter, randomized, double-blind, placebo-controlled trial [14].…”

Section: Introductionmentioning

confidence: 99%