Peppermint Oil Solution Is Useful as an Antispasmodic Drug for Esophagogastroduodenoscopy, Especially for Elderly Patients

Imagawa, Atsushi; Hata, Hidenori; Nakatsu, Morihito; Yoshida, Yasunari; Takeuchi, Keiko; Inokuchi, Toshihiro; Imada, Takayuki; Kohno, Yoshiyasu; Takahara, Masakazu; Matsumoto, Kazuyuki; Miyatake, Hirokazu; Yagi, Shunjiro; Ando, Masaharu; Hirohata, Mamoru; Fujiki, Shigeatsu; Takenaka, Ryuta

doi:10.1007/s10620-012-2194-4

Cited by 20 publications

(18 citation statements)

References 20 publications

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“…To reduce enteral spasm during diarrheal diseases, Mentha x piperita L. might be an efficient treatment option based on three clinical studies in humans, demonstrating efficient spasmolytic activity comparable to butylscopolamine [ 85 – 87 ]. The underlying mechanism includes inhibition of smooth muscle contractility through the block of calcium influx by menthol [ 88 ].…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

et al. 2016

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BackgroundGastrointestinal and respiratory diseases in calves and piglets lead to significant economic losses in livestock husbandry. A high morbidity has been reported for diarrhea (calves ≤ 35 %; piglets ≤ 50 %) and for respiratory diseases (calves ≤ 80 %; piglets ≤ 40 %). Despite a highly diverse etiology and pathophysiology of these diseases, treatment with antimicrobials is often the first-line therapy. Multi-antimicrobial resistance in pathogens results in international accordance to strengthen the research in novel treatment options. Medicinal plants bear a potential as alternative or additional treatment. Based on the versatile effects of their plant specific multi-component-compositions, medicinal plants can potentially act as ‘multi-target drugs’. Regarding the plurality of medicinal plants, the aim of this systematic review was to identify potential medicinal plant species for prevention and treatment of gastrointestinal and respiratory diseases and for modulation of the immune system and inflammation in calves and piglets.ResultsBased on nine initial sources including standard textbooks and European ethnoveterinary studies, a total of 223 medicinal plant species related to the treatment of gastrointestinal and respiratory diseases was identified. A defined search strategy was established using the PRISMA statement to evaluate 30 medicinal plant species starting from 20’000 peer-reviewed articles published in the last 20 years (1994–2014). This strategy led to 418 references (257 in vitro, 84 in vivo and 77 clinical trials, thereof 48 clinical trials in veterinary medicine) to evaluate effects of medicinal plants and their efficacy in detail. The findings indicate that the most promising candidates for gastrointestinal diseases are Allium sativum L., Mentha x piperita L. and Salvia officinalis L.; for diseases of the respiratory tract Echinacea purpurea (L.) MOENCH, Thymus vulgaris L. and Althea officinalis L. were found most promising, and Echinacea purpurea (L.) MOENCH, Camellia sinensis (L.) KUNTZE, Glycyrrhiza glabra L. and Origanum vulgare L. were identified as best candidates for modulation of the immune system and inflammation.ConclusionsSeveral medicinal plants bear a potential for novel treatment strategies for young livestock. There is a need for further research focused on gastrointestinal and respiratory diseases in calves and piglets, and the findings of this review provide a basis on plant selection for future studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0714-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

et al. 2016

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“…The intragastric administration of l -Menthol (LM) was found to reduce gastric spasm during EGD and to be more effective than the intramuscular injection of butyl scopolamine bromide 2 6 . The use of LM as an alternative antispasmodic agent would increase the safety of EGD, even in elderly patients 7 , with a possibly better detection of gastric lesions . We have therefore used LM as an antispasmodic agent.…”

Section: Introductionmentioning

confidence: 99%

l-Menthol sprayed on gastric mucosa causes edematous change

Mori

Hachiya

Yumura

et al. 2014

EIO

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Background and study aims: l-Menthol (LM), sprayed on the distal gastric mucosa, is a safe antispasmodic agent used during esophagogastroduodenoscopy (EGD). However, it seems to affect gastric mucosal endoscopic findings. Therefore, we evaluated whether LM causes specific changes and impacts the endoscopic morphology of gastric lesions. Patients and methods: A total of 98 patients scheduled to undergo EGD were randomly assigned to receive LM solution (160 mg of 0.8 % LM added to 2.5 mL of indigo carmine [IC]; n = 49; LM group) or decuple-diluted IC solution without LM (n = 49; placebo group). We compared the incidence of specific mucosal changes and the difference in the endoscopic findings of several gastric lesions between these groups. Results: Annular-reticular – like mucosal changes appeared immediately after the administration of LM solution. This change was observed in 71.4 % of the LM group compared with 12.2 % of the placebo group (P < 0.01). In the placebo group, this change was observed in 14.7 % of subjects with atrophic gastritis compared with 6.7 % of those without atrophic gastritis (P = 0.39), whereas in the LM group, this change was observed in 84.8 % of subjects with atrophic gastritis compared with 43.8 % of those without atrophic gastritis (P < 0.01). Most early gastric cancers, erosions, and ulcers observed in this study became well demarcated after LM administration, although the incidence of gastric lesions did not differ significantly between the two groups. Conclusion: LM changes the gastric mucosa into edematous mucosa, and this occurs more frequently in atrophic gastric mucosa than in pathologic lesions. LM may facilitate the demarcation of pathologic gastric lesions without intestinal metaplasia.

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“…Among the non-elderly patients, those in peppermint oil group had a worse antispasmodic score than those in hyoscine butyl bromide group. However, among the elderly patients, those in peppermint oil group had similar scores to those in hyoscine butyl bromide group [9]. These data suggest that peppermint oil is useful as an antispasmodic during esophagogastroduodenoscopy, especially for elderly patients.…”

Section: Clinical Evidencesmentioning

confidence: 57%

Mentha haplocalyx Briq. 薄荷 (Bohe, Mint)

Zhang

Qian

et al. 2015

Dietary Chinese Herbs

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Peppermint Oil Solution Is Useful as an Antispasmodic Drug for Esophagogastroduodenoscopy, Especially for Elderly Patients

Abstract: Peppermint oil was useful as an antispasmodic during EGD, especially for elderly patients.

Cited by 20 publications

References 20 publications

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

l-Menthol sprayed on gastric mucosa causes edematous change

Mentha haplocalyx Briq. 薄荷 (Bohe, Mint)

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