Peppermint oil/doxycycline hyclate-loaded Eudragit RS in situ forming gel for periodontitis treatment

Phaechamud, Thawatchai; Mahadlek, Jongjan; Tuntarawongsa, Sarun

doi:10.1007/s40005-017-0340-x

Cited by 20 publications

(18 citation statements)

References 49 publications

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“…Typically, adding a hydrophobic substance reduces the release rate of loaded drugs from controlled drug delivery systems. According to a previous study, incorporating hydrophobic oil into the in situ forming gel reduced the drug release rate [ 18 , 19 ]. The addition of clove oil to the Eudragit RS-based in situ forming gel reduced the release of DH by retarding the diffusion of solvent and drug with this oil addition [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The addition of clove oil to the Eudragit RS-based in situ forming gel reduced the release of DH by retarding the diffusion of solvent and drug with this oil addition [ 19 ]. Additionally, Eudragit RS in situ forming gel prepared using NMP and incorporating peppermint oil (PO) (2.5–5% w / w ) reduced DH release with an increased amount of PO [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…It has been discovered that the addition of additives to the in situ forming gel influences drug release and adhesive properties. For example, the addition of oils such as peppermint and clove into Eudragit RS in situ forming gel has been investigated to decrease the burst release of DH [ 18 , 19 ]. Additionally, the stickiness of in situ implants was enhanced by adding plasticizers and bio-adhesive polymers [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for preparing a solvent exchange-induced in situ forming gel. This study aims to investigate the role of incorporating lime peel oil (LO) on the physicochemical properties of injectable in situ forming gels based on rosin loaded with 5% w/w doxycycline hyclate (DH) in dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP). Their gel formation, viscosity, injectability, mechanical properties, wettability, drug release, and antimicrobial activities were evaluated. The presence of LO slowed gel formation due to the loose precipitate formation of gel with a high LO content. The viscosity and injectability were slightly increased with higher LO content for the DH-loaded rosin-based in situ forming gel. The addition of 10% LO lowered gel hardness with higher adhesion. LO incorporation promoted a higher drug release pattern than the no oil-added formulation over 10 days and the gel formation rate related to burst drug release. The drug release kinetics followed the non-Fickian diffusion mechanism for oil-added formulations. LO exhibited high antimicrobial activity against Porphyromonas gingivalis and Staphylococcus aureus. The DH-loaded rosin in situ forming gel with an addition of LO (0, 2.5, 5, and 10% w/w) inhibited all tested microorganisms. Adding 10% LO to rosin-based in situ forming gel improved the antimicrobial activities, especially for the P. gingivalis and S. aureus. As a result, the study demonstrates the possibility of using an LO amount of less than 10% loading into a rosin-based in situ forming gel for efficient periodontitis treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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“…The in situ forming system has emerged as a useful drug delivery system owing to its unique behavior of self-transformation at the target site. A liquid dosage form becomes semisolid or solid via various mechanisms, such as thermal trigger [ 1 , 2 ], pH change [ 3 ], solvent exchange [ 4 ], and chemical reaction [ 3 , 5 ]. The system has been focused on various application sites, such as the eyeball [ 6 ], periodontal pocket [ 7 ], articular joint [ 8 ], and muscle [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Saturated Fatty Acid-Based In Situ Forming Matrices for Localized Antimicrobial Delivery

et al. 2020

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In recent years, the world has faced the issue of antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant problem in various treatments and control of infections. Biocompatible materials with saturated fatty acids of different chain lengths (C8–C18) were studied as matrix formers of localized injectable vancomycin HCl (VCM)-loaded antisolvent-induced in situ forming matrices. The series of fatty acid-based in situ forming matrices showed a low viscosity (5.47–13.97 cPs) and pH value in the range of 5.16–6.78, with high injectability through a 27-G needle (1.55–3.12 N). The preparations exhibited low tolerance to high concentrations of KH2PO4 solution (1.88–5.42% v/v) and depicted an electrical potential change during phase transformation. Their phase transition and matrix formation at the microscopic and macroscopic levels depended on the chain length of fatty acids and solvent characteristics. The VCM release pattern depended on the nucleation/crystallization and solvent exchange behaviors of the delivery system. The 35% w/v of C12–C16 fatty acid-based in situ forming matrix prolonged the VCM release over seven days in which C12, C14, C16 –based formulation reached 56, 84, and 85% cumulative drug release at 7th day. The release data fitted well with Higuchi’s model. The developed formulations presented efficient antimicrobial activities against standard S. aureus, MRSA, Escherichia coli, and Candida albicans. Hence, VCM-loaded antisolvent-induced fatty acid-based in situ forming matrix is a potential local delivery system for the treatment of local Gram-positive infection sites, such as joints, eyes, dermis of surgery sites, etc., in the future.

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“…Peppermint oil is also used in novel formulations, for example as an anti-ulcer and anti-inflammatory agent in self-emulsifying drug delivery system for the improvement of meloxicam's solubility used in periodontal disease [65]. Furthermore, the study by Phaechamud et al [66] successfully used peppermint oil to modify the release of doxycycline from the in situ formed gel systems with Eudragit RS. Above studies demonstrate a modern trend on the development of innovative drug forms by using plant-based raw materials.…”

Section: Peppermint Leaves (Mentha Piperita)mentioning

confidence: 99%

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

Gościniak

Paczkowska-Walendowska

Skotnicka

et al. 2021

Pharmaceutics

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Periodontal diseases are one of the most significant challenges in dental health. It is estimated that only a few percent of the worldwide population have entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5 billion people worldwide. One of the most serious oral diseases is periodontitis, an inflammatory disease affecting periodontal tissues, caused by pathogenic bacteria and environmental factors such as the ageing population, abuse of tobacco products, and lack of adequate oral hygiene due low public awareness. Plant materials are widely and successfully used in the management of many conditions, including periodontitis. Plant materials for periodontitis exhibit antibacterial, anti-inflammatory, antioxidant activities and affect the periodontium structure. Numerous studies demonstrate the advantages of phytotherapy for periodontitis relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to analyze the use and applicability of selected plant materials in periodontitis management since it is of paramount importance to evaluate the evidence of the traditionally used plant materials in light of continuously growing interest in phytotherapy and its adjuvant role in the treatment of periodontitis.

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Peppermint oil/doxycycline hyclate-loaded Eudragit RS in situ forming gel for periodontitis treatment

Cited by 20 publications

References 49 publications

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Saturated Fatty Acid-Based In Situ Forming Matrices for Localized Antimicrobial Delivery

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

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