Pep-1 peptide-conjugated elastic liposomal formulation of taxifolin glycoside for the treatment of atopic dermatitis in NC/Nga mice

Kang, Myung Joo; Eum, Jae Yoon; Park, Sang Han; Kang, Mean Hyung; Park, Kwan Hee; Choi, Sun Eun; Lee, Min Won; Kang, Kyung Ho; Oh, Cheol; Choi, Young Wook

doi:10.1016/j.ijpharm.2010.09.030

Cited by 41 publications

(25 citation statements)

References 47 publications

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“…A lack of barrier substance is indicated by a reduction in skin hydration due to humidity loss and an increase in TEWL (Kircik, 2012). AD is defined by dysfunction of the stratum corneum that results in excessive TEWL and the infiltration of allergens into the skin (Kang et al, 2010). In atopic control group, TEWL values increased from 8 to 11 g/h/m 2 , while the skin barrier of the treated group with liposomes in gel (8 g/h/m 2 -6 g/h/m 2 ) and nanoparticle in gel (8 g/h/m 2 -7 g/h/m 2 ) were uniform at the end of the examinations.…”

Section: Treatment Efficacy Of Formulationsmentioning

confidence: 99%

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

et al. 2014

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Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal targeting. For this purpose, Betamethasone valerate (BMV)/Diflucortolone valerate (DFV)-loaded liposomes (220-350 nm) were prepared and incorporated into chitosan gel to obtain adequate viscosity ($13 000 cps). Drugs were localized in stratum corneum + epidermis of rat skin in ex-vivo permeation studies. The toxicity was assessed on human fibroblast cells. In point of in-vivo studies, pharmacodynamic responses, treatment efficacy and skin irritation were evaluated and compared with previously prepared nanoparticles. Liposome/ nanoparticle in gel formulations produced higher paw edema inhibition in rats with respect to the commercial cream. Similar skin blanching effect with commercial creams was obtained via liposome in gels although they contain 10 times less drug. Dermatological scoring results, prognostic histological parameters and suppression of mast cell numbers showed higher treatment efficiency of liposome/nanoparticle in gel formulations in AD-induced rats. TEWL and erythema measurements confirmed these results. Overview of obtained results showed that liposomes might be an effective and safe carrier for corticosteroids in skin disease treatment.

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Section: Treatment Efficacy Of Formulationsmentioning

confidence: 99%

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

et al. 2014

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“…115 TXG is a major flavonoid isolated from Rhododendron mucronulatum and Silybum marianum that inhibits microbial antigen-stimulated dendritic-cell mediated allergic responses in a dose-dependent manner. 116 TXG also reduces serum levels of eosinophils, IgE, IL-4, and IL-5 in NC/Nga (inbred stain mice established from Japanese fancy mice by Kondo [Nagoya University, Nagoya, Japan]) mice.…”

Section: Preclinical Applications As Antiscarring Anti-atopic Dermatmentioning

confidence: 99%

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Romero¹,

Morilla²

2013

IJN

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Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes ® (IDEA AG, Munich, Germany), ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route.

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“…12 ULs effectively increase the skin penetration of drugs both in vitro and in vivo. [13][14][15] Terpenes, a class of penetration enhancers obtained from natural sources, have successfully been used as skin penetration enhancers for percutaneous absorption enhancement in various types of liposomes, specifically invasomes, 16,17 and ULs. 18,19 Electron spin resonance (ESR), also known as electron paramagnetic resonance, is a spectroscopy technique used to study molecular mobility by characterizing the unpaired electron of free radicals, also called spin probes, in an extreme applied magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes

Subongkot¹,

Ngawhirunpat²

2015

IJN

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The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration.

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Pep-1 peptide-conjugated elastic liposomal formulation of taxifolin glycoside for the treatment of atopic dermatitis in NC/Nga mice

Cited by 41 publications

References 47 publications

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes

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