Peopling of Myanmar as Demonstrated by Genotyping of Urinary JC Virus DNA.

Dispersal of southeastern Asians based on a global phylogenetic analysis of JC polyomavirus isolates of genotype SC

“…Although the BP for SC-f was not high (63%), we found that all SC-f isolates examined carried a unique pentanucleotide deletion in the transcriptional control region (Saruwatari et al, 2002b), whereas this deletion was absent in all other subgroups (Table 1).…”

“…According to the phylogenetic tree (Figure 2), the SC isolates worldwide can be classified into several clusters, previously designated SC-a to -f and SC-x (Saruwatari et al, 2002b;Takasaka et al, 2004), with BPs ranging from 46% to 100%. Although the BP for SC-f was not high (63%), we found that all SC-f isolates examined carried a unique pentanucleotide deletion in the transcriptional control region (Saruwatari et al, 2002b), whereas this deletion was absent in all other subgroups (Table 1).…”

“…We determined the complete sequences of 15 clones containing full-length JCPyV genomes obtained in this and a previous study (Guo et al, 1996). The SC sequences thus obtained, those recently reported but left unclassified into subgroups (Cui et al, 2004;Venter et al, 2004), and those subclassified previously (Saruwatari et al, 2002b;Takasaka et al, 2004) were all subjected to a phylogenetic analysis. Furthermore, we performed a single nucleotide polymorphism (SNP) analysis of 275 reported partial SC DNA sequences worldwide.…”

“…Sugimoto et al (1997) found that this genotype occurs mainly in southeastern Asia and southern China, with minor SC isolates in central and northern Asia and southern Africa. Using phylogenetic analysis based on complete viral DNA sequences, Saruwatari et al (2002b) subclassified many SC isolates in Myanmar, together with a few in other countries, into six subgroups, SC-a to -f. Most subgroups (SC-a to -e) contained isolates in Myanmar, but one (SC-f) included isolates in various regions of southeastern Asia and southern China. Using complete viral DNA sequences, Takasaka et al (2004) analyzed phylogenetic relationships among JCPyV isolates in the Philippines and in other geographic regions.…”

“…To extend the findings of Saruwatari et al (2002b) and Takasaka et al (2004), we performed a profound phylogenetic analysis of many SC isolates recovered at various sites worldwide. We determined the complete sequences of 15 clones containing full-length JCPyV genomes obtained in this and a previous study (Guo et al, 1996).…”