People with Spinal Cord Injury in China

Reinhardt, Jan D.; Zheng, Yu; Xu, Guangxu; Lü, Xiao; Yin, Yan; Liu, Shouguo; Gao, Qiang; Xiong, Xianghu; He, Chengqi; Li, Hao; Li, Jianan

doi:10.1097/phm.0000000000000680

Cited by 22 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spinal cord injury (SCI) is a common condition that potentially results in the devastating and permanent loss of neurological function due to the failure of axonal regeneration after injury, thereby interrupting the connection between the brain and the body. Based on the available evidence, the incidence of SCI has increased dramatically during the past decade in China, primarily due to an increase in spinal trauma caused by motor vehicle crashes and falls [ 1 ]. The Global Burden of Diseases, Injuries, and Risk Factors Study reported 0.93 million (95% uncertainty interval [UI] 0.78–1.16 million) new cases of SCI, and SCI caused 9.5 million (95% UI 6.7–12.4 million) years of life lived with disability in 2016 [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice

et al. 2021

View full text Add to dashboard Cite

Background Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), or subsequently generated stem/progenitor cells, is predicted to be a promising treatment for SCI. In this study, we aimed to investigate effect of human iPSC-derived neural stem cells (hiPSC-NSCs) and umbilical cord-derived MSCs (huMSCs) in a mouse model of acute SCI. Methods Acute SCI mice model were established and were randomly treated as phosphate-buffered saline (PBS) (control group), repaired with 1 × 105 hiPSC-NSCs (NSC group), and 1 × 105 huMSCs (MSC group), respectively, in a total of 54 mice (n = 18 each). Hind limb motor function was evaluated in open-field tests using the Basso Mouse Scale (BMS) at days post-operation (dpo) 1, 3, 5, and 7 after spinal cord injury, and weekly thereafter. Spinal cord and serum samples were harvested at dpo 7, 14, and 21. Haematoxylin-eosin (H&E) staining and Masson staining were used to evaluate the morphological changes and fibrosis area. The differentiation of the transplanted cells in vivo was evaluated with immunohistochemical staining. Results The hiPSC-NSC-treated group presented a significantly smaller glial fibrillary acidic protein (GFAP) positive area than MSC-treated mice at all time points. Additionally, MSC-transplanted mice had a similar GFAP+ area to mice receiving PBS. At dpo 14, the immunostained hiPSC-NSCs were positive for SRY-related high-mobility-group (HMG)-box protein-2 (SOX2). Furthermore, the transplanted hiPSC-NSCs differentiated into GFAP-positive astrocytes and beta-III tubulin-positive neurons, whereas the transplanted huMSCs differentiated into GFAP-positive astrocytes. In addition, hiPSC-NSC transplantation reduced fibrosis formation and the inflammation level. Compared with the control or huMSC transplanted group, the group with transplantation of hiPSC-NSCs exhibited significantly improved behaviours, particularly limb coordination. Conclusions HiPSC-NSCs promote functional recovery in mice with acute SCI by replacing missing neurons and attenuating fibrosis, glial scar formation, and inflammation. Graphical abstract

show abstract

Section: Introductionmentioning

confidence: 99%

hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Spinal cord injury (SCI) is a common disease that potentially results in the devastating and permanent loss of neurological function due to the failure of axonal regeneration after injury, thereby interrupting the connection between the brain and the body. Based on the available evidence, the incidence of SCI has increased dramatically during the past decade in China, mainly due to an increase in spinal trauma caused by motor vehicle crashes and falls [1] . The Global Burden of Diseases, Injuries, and Risk Factors Study reported 0.93 million (95% uncertainty interval [UI] 0.78-1.16 million) new cases of SCI, and SCI caused 9.5 million (95% UI 6.7-12.4 million) years of life lived with disability in 2016 [2,3] .…”

Section: Introductionmentioning

confidence: 99%

HiPSC-Derived NSCs Effectively Promote The Functional Recovery of Acute Spinal Cord Injury in Mice

Kong

Feng

Asiamah

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), or subsequently generated stem/progenitor cells, is predicted to be a promising treatment for SCI. In this study, we aimed to investigate effect of human iPSC-derived neural stem cells (hiPSC-NSCs) and umbilical cord-derived MSCs (huMSCs) in a mouse model of acute SCI. Methods: Acute SCI mice model were established and were randomly treated as PBS (control group), repaired with 1×105 hiPSC-NSCs (NSC group), and 1×105 huMSCs (MSC group), respectively, in a total of 54 mice (n = 18 each). Hind limb motor function was evaluated in open-field tests using the Basso Mouse Scale (BMS) at days post-operation (dpo) 1, 3, 5 and 7 after spinal cord injury, and weekly thereafter. Spinal cord and serum samples were harvested at dpo 7, 14 and 21. HE staining and Masson staining were used to evaluate the morphological changes and fibrosis area. The differentiation of the transplanted cells in vivo was evaluated with immunohistochemical staining. Results: The hiPSC-NSC-treated group presented a significantly smaller GFAP+ area than MSC-treated mice at all time points. Additionally, MSC-transplanted mice had a similar GFAP+ area to mice receiving PBS. At dpo14, the immunostained hiPSC-NSCs were positive for SOX2. Furthermore, the transplanted hiPSC-NSCs differentiated into glial fibrillary acidic protein (GFAP)-positive astrocytes and beta-III tubulin-positive neurons, whereas the transplanted huMSCs differentiated into GFAP-positive astrocytes. In addition, hiPSC-NSC transplantation reduced fibrosis formation and the inflammation level. Compared with the control or huMSC transplanted group, the group with transplantation of hiPSC-NSCs exhibited significantly improved behaviours, particularly limb coordination. Conclusions: HiPSC-NSCs promote functional recovery in mice with acute SCI by replacing missing neurons and attenuating fibrosis, glial scar formation, and inflammation.

show abstract

“…Reliable epidemiological data and evidence of SCI in China are vital for estimating the number of patients, finding out the main causes, developing interventions, providing up-to-date information, and raising public awareness. Previous studies have reported the incidence of SCI in China increased significantly ( 16 ). Therefore, it is of great significance to review all the research data of SCI in China to attain a comprehensive understanding of its epidemiological features so as to improve management and reduce the financial burden on patients and healthcare system.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Features of Spinal Cord Injury in China: A Systematic Review

et al. 2018

View full text Add to dashboard Cite

Background: Spinal cord injury (SCI) is a severe condition that disrupts patients' physiological, mental, and social well-being state and exerts great financial burden on patients, their families and social healthcare system. This review intends to compile studies regarding epidemiological features of SCI in China.Methods: Searches were conducted on PubMed, EMBASE, Web of Science and Cochrane Library for relevant studies published through January, 2018. Studies reported methodological and epidemiological data were collected by two authors independently.Results: Seventeen studies met the inclusion criteria. Two studies reported incidence of SCI that is 60.6 in Beijing (2002) and 23.7 in Tianjin (2004–2008). All studies showed male had a larger percentage in SCI compared to female except Taiwan (2000–2003). The average male and female ratio was 3–4:1 in China and the highest male and female ratio was 5.74: 1 in Tianjin (2004–2007). Farmers, laborers and unemployed people accounted for more than half of the SCI patients in China. Fall was the primary causation with exception of Heilongjiang (2009–2013), Beijing (2001–2010), and Taiwan (2002–2003), where motor vehicle collision (MCVs) was the leading causation. Pulmonary infection, urinary tract infection and bedsore were common complications, accounting for approximately 70% of SCI patients in China.Conclusion: This review shows that epidemiological features of SCI are various in different regions in China and prevention should be implemented by regions. The number of patients with SCI result from fall and MCVs may become a main public health problem because population aging and economic developing in China. However, because all included studies were retrospective and lacking a register system in China, some data were incomplete and some cases may be left out, so the conclusion may not be generalizable to the other regions.

show abstract

People with Spinal Cord Injury in China

Cited by 22 publications

References 15 publications

hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice

hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice

HiPSC-Derived NSCs Effectively Promote The Functional Recovery of Acute Spinal Cord Injury in Mice

Epidemiological Features of Spinal Cord Injury in China: A Systematic Review

Contact Info

Product

Resources

About