Pentylenetetrazol: Failure to Improve Memory in Mice

Pearl, Jack; McKean, Donna B.; Irwin, S. T.

doi:10.1126/science.157.3785.220

Cited by 8 publications

References 1 publication

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Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

Levinthal

Papsdorf

1970

Psychopharmacologia

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Postsession strychnine injections have been shown to retard acquisition rates of the classically conditioned nictitating membrane response (CCNMR) of rabbits trained at a CS-US interval of 1000 msec. The particular interval value employed in CCNIRR acquisition was found to be important in the magnitude of the postsession strychnine effect. Strychnine Ss trained at a CS-US interval ~ 1250 msee (nonoptimal) were significantly depressed in acquisition rates relative to saline controls, while strychnine Ss trained at a CS-US interval-250 msec (optimal) were not. Interpretations are based upon the presumed effects of CNS excitants on memory consolidation and possible neurological correlates of the CS-US interval parameter.

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Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

Levinthal

Papsdorf

1970

Psychopharmacologia

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Facilitation of avoidance learning by pentylenetetrazol as a function of task difficulty, deprivation and shock level

Krivanek

1971

Psychopharmacologia

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Differences in the effects of post-trial chlorpromazine, reserpine, and amphetamine on discrimination learning in rats

Ito¹,

Saito²

1976

Psychopharmacology

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Rats were trained to perform in discrimination learning reinforced by water for 6 days, and were intraperitoneally injected with chlorpromazine, reserpine, or d-amphetamine after each training session. Although chlorpromazine at the dose levels of 0.5 mg/kg or more injected immediately after training impaired learning, the drug did not affect learning when it was injected 60 min after training. Reserpine and amphetamine also impaired learning, but delaying the time intervals between training and injection to 60 min or more had no influence on this learning impairment. Post-trial chlorpromazine and amphetamine had no effect on, but reserpine decreased, motility in the subsequent training session. Chlorpromazine had no effect on water intake in the subsequent session, but reserpine and amphetamine decreased water intake at the dose levels that impaired learning. It was concluded that all three drugs impaired learning, but differed in their effects on learning; chlorpromazine impaired learning by a specific effect on learning itself; reserpine, by a non-specific effect on behavior due to a long acting sedation; and amphetamine, by an effect to decrease the motivation to drink water. The specific effect of chlorpromazine could be related to the hypothesis of "memory trace" synthesis.

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Pentylenetetrazol: Failure to Improve Memory in Mice

Cited by 8 publications

References 1 publication

Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

Facilitation of avoidance learning by pentylenetetrazol as a function of task difficulty, deprivation and shock level

Differences in the effects of post-trial chlorpromazine, reserpine, and amphetamine on discrimination learning in rats

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