Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy

Abstract

Glioblastoma is the most malignancy tumor generated from the central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association with patients' poor survival outcome in various tumor. Recently, several studies revealed its association with glioblastoma progression but the mechanism is remained unknown. Autophagy is a programmed cells death and acts critical role in tumor progression. In this study, pentraxin 3 is recognized as prognostic prediction biomarker of glioblastoma and can promote glioblastoma progression through negative modulating tumor cells autophagy. Transcription factor JUN is assumed to participate in cells autophagy modulation by regulating pentraxin 3 expression. This work reveals novel mechanism of pentraxin 3 mediated glioblastoma progression. Furthermore, JUN is identified as potential transcription factor involves in pentraxin 3 mediated tumor cells autophagy.

PTX3 mediates the infiltration, migration, and inflammation‐resolving‐polarization of macrophages in glioblastoma

“…In our previous findings, PTX3 in CL and ME subtypes was also higher than that in NE and PN subtypes in GBM samples, and the AUC value of PTX3 was 84.2% in GBM based on the TCGA RNA-seq data. 23 In this study, the ROC curves further confirmed that PTX3 with the AUC values of 92.1% and 95.0% in…”

“…PTX3 is a double‐edged sword in carcinogenesis, which depends on the specific tumor microenvironment. Meanwhile, PTX3 has been associated with the tumor grade and malignancy of gliomas 23 . It should be noted that our previous finding proved that PTX3 promoted GBM progression by negatively regulating cell autophagy 23 .…”

Ferroptosis-Related Gene Signature Promotes Ovarian Cancer by Influencing Immune Infiltration and Invasion

“…e GO and KEGG analyses were analyzed by conducting the GSVA and the GSEA analysis, respectively [32,33].…”

Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas

“…Compared with patients in cluster 2, patients in cluster 1 had a lower survival probability and a worse prognosis. In different types and grades of gliomas, higher levels of IDH WT, MGMT promoter unmethylation, and 1p19q noncodeletion are more common in high-grade gliomas and the subtype of ME whose prognosis is worse ( 39 ). These are associated with a more malignant glioma phenotype with worse prognosis.…”

“…Studies have shown that GAMs could promote tumor growth by secreting immunosuppressive factors and other factors that supported tumor invasion ( 54 ). The decreased expression of TNF-α in cluster 1 may represent the impaired function of M1 in GBM, and the increased expression of IL-1β promotes the proliferation and migration of GAMs ( 39 , 55 , 56 ). The gene expression pattern of GAMs is similar to those of all of M0-type, M1-type, and M2-type macrophages ( 57 ).…”