Pentraxin 3 genotyping in relation to serum levels of pentraxin 3 in patients with acute ST-segment elevation myocardial infarction

Melegy, Ehab Kamal El; Badr, Eman; Elkersh, Ahmed; Shafey, Wassam H. El; Fareed, W.

doi:10.1016/j.ctrsc.2015.11.002

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…The risk of IS was generally correlated with the prevalence of heterozygous genotypes in our patients. Similar direction of the association was demonstrated in the study of Melegy et al [ 38 ], who tested the association of SNP rs2305619 with AMI (SNP rs2305619 was in strong linkage disequilibrium (LD; r 2 = 0.97) with our SNP rs2316710 in CEU test population from 1000 Genomes Project [ 15 ]). At the same time, no such correlations were observed in the larger study of Barbati et al [ 39 ], who explored the influence of PTX3 polymorphisms on the risk of AMI and pentraxin-3 plasma levels (the SNPs tested were in strong LD with our SNPs rs2316710 and rs7634847, but not with rs62278647 ( r 2 = 0.47–0.69), in CEU test population [ 15 ]).…”

Section: Discussionsupporting

confidence: 84%

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study

Khrunin¹,

Khvorykh²,

Rozhkova³

et al. 2021

Genes

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Although there has been great progress in understanding the genetic bases of ischemic stroke (IS), many of its aspects remain underexplored. These include the genetics of outcomes, as well as problems with the identification of real causative loci and their functional annotations. Therefore, analysis of the results obtained from animal models of brain ischemia could be helpful. We have developed a bioinformatic approach exploring single nucleotide polymorphisms (SNPs) in human orthologues of rat genes expressed differentially under conditions of induced brain ischemia. Using this approach, we identified and analyzed nine SNPs in 553 Russian individuals (331 patients with IS and 222 controls). We explored the association of SNPs with both IS outcomes and with the risk of IS. SNP rs66782529 (LGALS3) was associated with negative IS outcomes (p = 0.048). SNPs rs62278647 and rs2316710 (PTX3) were associated significantly with IS (p = 0.000029 and p = 0.0025, respectively). These correlations for rs62278647 and rs2316710 were found only in women, which suggests a sex-specific association of the PTX3 polymorphism. Thus, this research not only reveals some new genetic associations with IS and its outcomes but also shows how exploring variations in genes from a rat model of brain ischemia can be of use in searching for human genetic markers of this disorder.

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Section: Discussionsupporting

confidence: 84%

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study

Khrunin¹,

Khvorykh²,

Rozhkova³

et al. 2021

Genes

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“…Для рациональной стратификации риска у пациентов с ИМпST и получения дополнительной прогностической информации было предположено использовать комбинацию сывороточных биомаркеров, участвующих в различных патологических реакциях при ССС [11]. Большинство мультимаркерных подходов включают добавление новых многообещающих биомаркеров к уже хорошо изученным ФР [12,13]. Пациенты высокого риска имеют большую продолжительность госпитализации, частоту обращений в поликлинику, частоту имплантаций кардиодефибрилляторов и поэтому им рекомендована другая стратегия вторичной профилактики, реабилитации и т. п.…”

Section: Discussionunclassified

“…Ehab K, et al (2016) определяли уровень сывороточного Ptx-3 у пациентов с ИМпST. У пациентов с ИМпST уровень Ptx-3 был значительно выше, чем у группы сравнения, и его рекомендовали в качестве раннего маркера ИМ [13]. Точка отсечения была 4,35 нг/мл, также ниже, чем в нашем исследовании.…”

Section: Discussionunclassified

Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction

et al. 2020

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“…В ходе исследования Ehab K, et al (2016) определялся уровень сывороточного Ptx-3 у пациентов с ИМ с подъемом сегмента ST. Пациенты с ИМ имели значительно более высокие уровни Ptx-3, чем в контрольной группе, и данный биомаркер был рекомендован как ранний маркер ОКС. При этом точка отсечения составила 4,35 нг/мл, что значительно меньше, чем в нашем исследовании, что возможно объясняется определением точек отсечения для событий в отдалённом периоде [14].…”

Section: Discussionunclassified

Analysis of distant cardiovascular events depending on the biomarker profile in patients with myocardial infarction

et al. 2019

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Acute coronary syndrome (ACS) and its complications is one of the main reasons of mortality and invalidation in the world. New biomarkers, such as ST2, NT-proBNP и Pentraxin-3 (Ptx-3) present much more opportunities in the diagnostics of diseases and risk of its development.Aim.To investigate standards and “new” biomarkers in different variants of MI and cardiovascular events in 1 year after MI.Material and methods.In 180 patients with MI (61,4±1,7 years) we determined the serum concentration of standard and “new” (ST2, NT-proBNP, Ptx-3) biomarkers in groups with Q/non-Q, STEMI and NSTEMI and the endpoints (MI, strokes, repeated hospitalizations and sudden deaths) in 1 year (384,3±21,2 days) after MI.Results.Patients with Q-MI and STEMI had higher risk of unfavorable cardiovascular events (p<0,05). Ptx-3 >43,9 ng/ml was shown to be risk factor for sudden death (sensitivity 70,0%, specificity 52,9%), and >125,9±0,06 ng/ml (74,1% and 44,1%) — of recurrent MI.Conclusion.NT-proBNP, ST2 and Ptx-3 showed prognostic value in the diagnostics of unfavorable cardiovascular endpoints.

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Pentraxin 3 genotyping in relation to serum levels of pentraxin 3 in patients with acute ST-segment elevation myocardial infarction

Cited by 6 publications

References 36 publications

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study

Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction

Analysis of distant cardiovascular events depending on the biomarker profile in patients with myocardial infarction

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