Pentoxifylline: wonder drug?

Marks, SL; Merchant, Stephanie; Foil, C

doi:10.5326/15473317-37-3-218

Cited by 10 publications

(13 citation statements)

References 5 publications

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“…Increased PDE activity seems to be responsible for the deficient cyclic adenosine monophosphate (cAMP) response in atopic dogs and humans 1,4,11) . Pentoxifylline (PTX) is a methylxanthine derivative and a nonselective PDE inhibitor 3,7,11,20,22) . PDE inhibition produces increased intracellular concentrations of cAMP, which has numerous cell-stabilizing and antiinflammatory effects (Table 1) 3, 5-7, 11, 13, 15, 20, 22, 24) .…”

Section: Introductionmentioning

confidence: 99%

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Pentoxifylline for the Management of Pruritus in Canine Atopic Dermatitis: An Open Clinical Trial with 37 Dogs

Scott

Miller

2007

Jpn J Vet Dermatol

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Thirty-seven dogs with chronic canine atopic dermatitis (CAD) were treated with pentoxifylline (PTX), 25 mg/kg every 12 hours, given orally with food for at least 4 weeks. Sixteen dogs (43%) were successfully managed: with PTX alone (7 dogs, 19%), PTX with allergen-specific immunotherapy (5 dogs, 13.5%), or PTX with oral glucocorticoids (4 dogs, 10.5%), with follow-up periods of 5 months to 2.5 years. PTX was well-tolerated: one dog refused to take the drug, and one dog developed diarrhea. PTX was found to be a useful nonsteroidal antipruritic agent for many dogs with CAD.

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Section: Introductionmentioning

confidence: 99%

“…PTX has been used in veterinary dermatology to treat a great number of skin disorders 7,10,16,17,22,23) . Virtually all such information is anecdotal.…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline for the Management of Pruritus in Canine Atopic Dermatitis: An Open Clinical Trial with 37 Dogs

Scott

Miller

2007

Jpn J Vet Dermatol

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“…Pentoxifylline (PTX) is a member of the class of drugs that inhibit nonselectively phosphodiesterase (PDE) enzymes, referred to as PDE inhibitors (Marks et al. , 2001; Scott et al.…”

Section: Clinical Cadesi and Vas Score For Pruritus Of Group I Ii mentioning

confidence: 99%

“…, 1995). PTX has been reported to have a steroid‐sparing effect in dogs and humans (Marsella, 2000; Marks et al. , 2001).…”

Section: Clinical Cadesi and Vas Score For Pruritus Of Group I Ii mentioning

confidence: 99%

Therapeutic management of canine atopic dermatitis by combination of pentoxifylline and PUFAs

Singh

Dimri

Saxena

et al. 2010

Vet Pharm & Therapeutics

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“…At least 11 different metabolites of caffeine have been identified in mammalian systems [11,[15][16][17][18][19]. In the clinic, some of caffeine major metabolites are used to treat several diseases [20][21][22][23][24][25][26][27][28][29]. However, some caution must be exerted in regard to the appropriate dosage use.…”

Section: Introductionmentioning

confidence: 99%

Determination of caffeine and its metabolites in urine by capillary electrophoresis‐mass spectrometry

et al. 2005

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The caffeine content of foods and beverages varies considerably, interfering with our ability to obtain valid interpretations in many human studies with regard to the mechanism of action(s) of caffeine and/or its metabolites. The rate of metabolism of caffeine and other xanthine drugs also varies greatly from one individual to another. Therefore, it is extremely important to develop accurate, reliable analytical methods to quantify caffeine and its metabolites in simple and complex matrixes. A simple method is described for the separation and characterization of caffeine and its major metabolites employing capillary electrophoresis (CE) coupled to ultraviolet-absorption and mass spectrometry (MS) detection. After optimization of the electrophoresis separation conditions, a reliable separation of caffeine and 11 of its major metabolites was achieved in 50 mM ammonium carbonate buffer, pH 11.0. The volatile aqueous electrolyte system used with a normal electroosmotic flow polarity also provided an optimal separation condition for the characterization of the analytes by MS. The CE method achieved baseline resolution for all 12 compounds in less than 30 min. The CE-MS method is suitable for use as a routine procedure for the rapid separation and characterization of caffeine and its metabolites. The usefulness of this method was demonstrated by the extraction, separation, and identification of caffeine and its 11 metabolites from normal urine samples. The urine specimens were first acidified to obtain optimum binding efficiency to the sorbents of the off-line, solid-phase extraction procedure employed here, and an acidified eluent solvent was employed for the desorption step to maximize the recovery of the bound analytes.

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Pentoxifylline: wonder drug?

Cited by 10 publications

References 5 publications

Pentoxifylline for the Management of Pruritus in Canine Atopic Dermatitis: An Open Clinical Trial with 37 Dogs

Pentoxifylline for the Management of Pruritus in Canine Atopic Dermatitis: An Open Clinical Trial with 37 Dogs

Therapeutic management of canine atopic dermatitis by combination of pentoxifylline and PUFAs

Determination of caffeine and its metabolites in urine by capillary electrophoresis‐mass spectrometry

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