Pentoxifylline in the Treatment of Radiation-Induced Fibrosis

Okunieff, Paul; Augustine, Elizabeth; Hicks, Jeanne E.; Cornelison, Terri L.; Altemus, R.; Naydich, Boris G.; Ding, Ivan; Huser, Amy K.; Abraham, Edward; Smith, Judith J.; Coleman, Norman; Gerber, Lynn H.

doi:10.1200/jco.2004.09.101

Cited by 145 publications

(98 citation statements)

References 30 publications

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“…It also showed no side effects which was similar to the study by Mathew et al, [16,33]. Pentoxyfilline is known to cause side effects with gastrointestinal tract like dyspepsia, nausea, vomiting and central nervous problems like dizziness, head ache, anxiety, confusion and tremors [15,34]. In our study two patients had bloating of stomach, nausea and gastritis.…”

Section: Discussionsupporting

confidence: 91%

Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis

Mulk

Deshpande

Velpula

et al. 2013

JCDR

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Background: Oral submucous fibrosis is a habit associated insidious precancerous condition of the oral cavity commonly found in Asian countries. Many treatment modalities have been attempted in treating the condition apart from steroids which have been the main stay. Hence the present study was designed to assess the efficacy of spirulina and pentoxyfilline and also to compare them in oral submucous fibrosis. Material and Methods:Fourty Patients with clinico-histological diagnosis of oral sub mucous fibrosis were selected and divided into two groups with 20 in each group by simple randomization method. Group I received Pentoxyfilline and Group II Spirulina for period of 3 months. The efficacy was assessed by parameters like mouth opening, burning sensation and tongue protrusion using vernier caliper, visual analog scale and a metric scale respectively along with the side effects.

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Section: Discussionsupporting

confidence: 91%

Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis

Mulk

Deshpande

Velpula

et al. 2013

JCDR

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“…Dion et al [36] reported the preliminary results of PTX contributing to wound healing following radiation injury. A combination of vitamin E or tocopherol along with PTX was shown to reduce radiation-induced fibrosis of the skin [37], as well as early and late radiation adverse effects in patients treated for lung and breast cancer [38,39,40]. Vitamin E acts as a scavenger for free radicals released and protects cell membranes and may potentiate the benefits of PTX in the treatment of RN.…”

Section: Discussionmentioning

confidence: 99%

Laser Interstitial Thermal Therapy for Focal Cerebral Radiation Necrosis: A Case Report and Literature Review

Rahmathulla

Recinos

Valerio

et al. 2012

Stereotact Funct Neurosurg

150

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Whole-brain radiotherapy and stereotactic radiosurgery (SRS) play a central role in the treatment of metastatic brain tumors. Radiation necrosis occurs in 5% of patients and can be very difficult to treat. The available treatment options for radiation necrosis include prolonged high-dose corticosteroids, hyperbaric oxygen, anticoagulation, bevacizumab, and surgical resection. We present the first report and results using laser-interstitial thermal therapy (LITT) for medically refractory radionecrosis. A 74-year-old diabetic patient who had a history of non-small cell lung cancer with brain metastases and subsequent treatment with SRS, presented with a focal lesion in the left centrum semiovale with progressively worsening edema. Image findings were consistent with radiation necrosis that was refractory despite prolonged, high-dose steroid therapy. His associated comorbidities obviated alternative interventions and the lesion was not in a location amenable to surgical resection. We used laser thermal ablation to treat the biopsy-proven radionecrosis. The procedure was tolerated well and the patient was discharged 48 hours postoperatively. Imaging at 7-week follow-up showed near complete resolution of the edema and associated mass effect. Additionally, the patient was completely weaned off steroids. To our knowledge this is the first report using LITT for the treatment of focal radiation necrosis. LITT may be an effective treatment modality for patients with medically refractory radiation necrosis with lesions not amenable to surgical decompression.

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“…In addition, ascorbic acid treatment improved survival and caused dose-dependent elevation of wound contraction in mice exposed to combined radiation and wound. The COX2 inhibitors pentoxifylline and esculentoside A are proposed to be beneficial in controlling inflammatory cytokines and protecting against radiation (66,67).…”

Section: Therapeutic Approaches To Rcimentioning

confidence: 99%

Ghrelin as a Novel Therapy for Radiation Combined Injury

Jacob

Shah

et al. 2010

Mol Med

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The threat of nuclear terrorism has led to growing worldwide concern about exposure to radiation. Acute radiation syndrome, or radiation sickness, develops after whole-body or a partial-body irradiation with a high dose of radiation. In the terrorist radiation exposure scenario, however, radiation victims likely suffer from additional injuries such as trauma, burns, wounds or sepsis. Thus, high-dose radiation injuries and appropriate therapeutic interventions must be studied. Despite advances in our understanding of the pathophysiology of radiation injury, very little information is available on the therapeutic approaches to radiation combined injury. In this review, we describe briefly the pathological consequences of ionizing radiation and provide an overview of the animal models of radiation combined injury. We highlight the combined radiation and sepsis model we recently established and suggest the use of ghrelin, a novel gastrointestinal hormone, as a potential therapy for radiation combined injury.

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Pentoxifylline in the Treatment of Radiation-Induced Fibrosis

Abstract: Patients receiving pentoxifylline demonstrated improved AROM, PROM, and muscle strength and decreased limb edema and pain. Reversal of these delayed radiation effects was associated with a decrease in circulating FGF2.

Cited by 145 publications

References 30 publications

Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis

Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis

Laser Interstitial Thermal Therapy for Focal Cerebral Radiation Necrosis: A Case Report and Literature Review

Ghrelin as a Novel Therapy for Radiation Combined Injury

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