Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas

Collingridge, David R.; Rockwell, Sara

doi:10.1002/1097-0215(20001020)90:5<256::aid-ijc2>3.0.co;2-r

Cited by 32 publications

(18 citation statements)

References 35 publications

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“…11 Morever, it has been reported that pentoxifylline can improve tumor oxygenation and radiation responses. 12 However, few radiosensitizers are available on the market due to the difficulty and high cost of large-scale production; thus, development of new radiotherapy agents is of scientific and clinical interest.…”

Section: Introductionmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi 2 Se 3 -CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi 2 Se 3 -CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi 2 Se 3 -CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi 2 Se 3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi 2 Se 3 NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

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Section: Introductionmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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“…The effects of pentoxifylline on membranes may explain its effects on cell deformability, inhibition of neutrophils priming by TNF-␣, diminished adherence and aggregation, reduced superoxide production, and improved locomotor responses (22). The positive influence of pentoxifylline on the microcirculation and peripheral oxygenation led to applications of the drug in experimental radiotherapy to improve oxygenation and in restoring the radiobiological effectiveness of photon irradiation (23)(24)(25)(26). In these experiments, pentoxifylline was shown to diminish the incidence and severity of late radiation injury.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Pentoxifylline on Growth Plate in Neonatal Rats Following Long-Term Phototherapy

2007

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ABSTRACT:We demonstrated previously that receiving long-term phototherapy was associated with early impairment of growth plate structure in neonatal rats, and oxidative stress may be the main risk factor for growth plate injury. The purpose of this study was to examine the histomorphometric effects of pentoxifylline treatment on the growth plate. Sixty weanling Sprague-Dawley rats were randomly separated into three equal groups. Group A, the control group, did not receive phototherapy and pentoxifylline. Groups B and C were exposed to phototherapy for 7 d. In addition to phototherapy, group C was also given pentoxifylline during the study period. Compared with zonal lengths on d 7 after initiation of phototherapy, group B had significantly lower values than group A for all zonal lengths (p Ͻ 0.001). Zonal lengths of growth plate were increased significantly with pentoxifylline treatment in group C for 7 d compared with group B (p Ͻ 0.001). After phototherapy, group B had significantly higher values than groups A and C for plasma malondialdehyde levels (p Ͻ 0.001). The pentoxifylline was found here to have some potential to reduce the effects of phototherapy on growth plate in neonatal rats at a relatively low dose. T he growth plate is a highly organized cartilage structure located between the epiphyseal and metaphyseal bones at the distal ends of the long bones (1). Longitudinal bone growth is the result of chondrocyte proliferation and subsequent differentiation in the epiphyseal growth plates of the long bones. It is regulated by a multitude of genetic and hormonal factors, growth factors, environment, and nutrition (2-5). Regarding effects of radiation therapy on chondrocytes, Pateder et al. observed no change in transforming growth factor ␤ (TGF-␤) gene expression (6), whereas Margulies et al. found that TGF-␤ expression decreased and fibroblast growth factor 2 increased after irradiation (7). Moreover, there is evidence that growth plate chondrocytes, osteoclast precursors, and vascular endothelial cells are more sensitive to radiation than osteoblasts (8 -10). All these contribute to establishing the final height of an individual.Phototherapy administered to newborns with jaundice is considered to be a rather benign procedure with few side effects such as rash, loose stools, increased insensible water loss, and dehydration (11). Although phototherapy has been in use for a long time and its effects on the body have been studied extensively, so far, no studies have investigated the relationship between the growth plate and phototherapy. We previously showed the damaging effect of phototherapy by increased oxidative stress on growth plate in newborn rats. Moreover, we showed functional damage and a harmful effect on longitudinal growth of phototherapy on the SpragueDawley rat growth plate (12). Therefore, we hypothesized that pentoxifylline would ameliorate the adverse effects of phototherapy on the growth plate. METHODS Study groups.Sixty weaning Sprague-Dawley rats were randomized into three groups. As all...

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“…The MRI microimaging was performed before and after placing 10 nm CNT in glass capillaries at different intervals of 2,4,6 hours using scan parameters: TR/TE/flip angle = 750 ms/4.18 ms/25°, FOV/matrix size/spatial resolution = 2.6 x 3.4 cm/ 256 x 256/0.015 mm, and the inversion time (TI approximately 250 ms) set to null normal skin. Epidermis and hair follicle were measured as reported by Sharma et al (2010) [60].…”

Section: Characterization and Toxicity Of Swcnt And Mwcnt Carbon Nanomentioning

confidence: 99%

“…Initially, hypoxia induced by CNT was estimated by clonogenic assay of clonogenic cell survival [59][60][61]. Oxygen pressure measurement of poor oxygenation in tumor cells is other method of cytotoxicity testing.…”

Section: Characterization and Toxicity Of Swcnt And Mwcnt Carbon Nanomentioning

confidence: 99%

Carbon Nanotubes: Nanotoxicity Testing and Bioapplications

Sharma¹,

Kwon²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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With the growing use of nanomaterials in bioapplications, the nanotoxicity of new nanomaterials has become a safety concern when used in various applications. In this chapter, technical developments on carbon nanotubes are described including a historical account, experimental models and potential bioapplications.Carbon nanotube (CNT) materials display superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to the unique CNT structure with high-aspect ratio, CNT may show unusual toxicity and complicate its safe use in a target tissue. To test nanotoxicity of CNT, we describe a set of protocols of prior knowledgebased physical and chemical characteristics to develop 3-dimensional in vitro models of the intact skin, and a 3D in vitro model of the human airway using a co-culture of normal human bronchial epithelial cells and normal human fibroblasts. The human airway 3D model served as a tool of health risk assessment of CNTs on the human respiratory systems. To test functionality at different CNT concentrations in a 3D model, physical characteristics of multiwalled CNTs and production of nitric oxide (NO) served as cell viability and inflammatory marker; mitochondrial activity (MTT assay) served as the cytotoxic response of the epithelial cell layers; transepithelial electrical resistance (TER) measured nanotoxicity in the changes in airway physiological function. Cytoxicity and inflammatory responses of CNTs were dependent on different size, mass, shape, and functionality of CNTs as viable in vivo tests were conducted to evaluate the Ashutosh Tiwari and Atul Tiwari (eds.) Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering,

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Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas

Cited by 32 publications

References 35 publications

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

Protective Effect of Pentoxifylline on Growth Plate in Neonatal Rats Following Long-Term Phototherapy

Carbon Nanotubes: Nanotoxicity Testing and Bioapplications

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