Pentoxifylline Effects on Acute and Late Complications after Radiotherapy in Rabbit

Aygenç, Erdinç; Celikkanat, Serdar; Bilgili, Hasan; Aksaray, Ferdi; Orhun, Sibel; Kaymakçı, Mustafa; Özdem, Cafer

doi:10.1177/019459980112400614

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…The prophylactic administration of this antifibrotic in the postirradiation period can reduce late radiation injury by (i) increasing red blood cell deformability and prostacyclin release, (ii) inhibiting the activation of neutrophils and (iii) inhibiting the production of thromboxane (50). In some studies, it has decreased the rate of late radiation reaction, but no proven effect has been observed for acute radiation reactions (50,51).…”

Section: Adjunctive Therapiesmentioning

confidence: 99%

Wound healing in radiated skin: pathophysiology and treatment options

Olascoaga

Vilar‐Compte

Poitevin-Chacón

et al. 2008

International Wound Journal

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Ulcers in radiated skin continue to be a challenge for health care practitioners. Healing impairment in the setting of radiation-damaged tissue will most of the time lead to chronic wounds that reduce the patient's quality of life. In this review, we present an update of the pathophysiology of tissue damage caused by radiation that leads to chronic ulceration. We also explore the evidence available on the different prevention and treatment modalities that have been reported in the literature. The evidence for most preventive measures is inconclusive; however, sucralfate and amifostine seem to be the adequate recommendations for prophylaxis. As for treatment of ulcerated patients, the strongest level of evidence found was for the use of pentoxifylline, but proper trials are still scarce to be considered standard adjuvant therapy. Hyperbaric oxygen, cytokines and other growth factors and surgical interventions have shown some benefit in case reports and case series only. Other therapies show promise based on their mechanism of action but need to be tested in human studies and clinical trials.

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Section: Adjunctive Therapiesmentioning

confidence: 99%

Wound healing in radiated skin: pathophysiology and treatment options

Olascoaga

Vilar‐Compte

Poitevin-Chacón

et al. 2008

International Wound Journal

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“…As a result, it was concluded that pentoxifylline had a protective effect. [12,13] In a clinical study conducted by the same investigator on 87 cases, pentoxifylline did not have any effects on the early period effects of radiation (p>0.05), whereas there was a significant difference between the late-period results (p<0.05). [14] In a retrospective study examining the late-period effects of RT that are permanent and decrease the quality of life, 30 cases received pentoxifylline 400 mg three times daily for 8 weeks.…”

Section: Discussionmentioning

confidence: 96%

“…[18] Pentoxifylline, which prevents the negative effects of RT by promoting blood circulation and oxygenation in the tissues, fits this definition. [9,13,15] In the present study, we preferred pentoxifylline because it is systemically easy to use, has negligible side effects, and reduces the local effects of RT. We compared, examined, and shared the results of patients with breast cancer that used pentoxifylline for prophylactic purposes following IOERT and WBRT; to the best of our knowledge, this subject has not been studied in the literature yet.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pentoxifylline in Protection the Breast Tissue Against Radiation Injury

Günay¹

2020

TJ Oncol

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To investigate the protective effect of pentoxifylline against radiation injury in patients with breast cancer. METHODS A total of 82 patients with early-stage breast cancer who underwent breast-conserving surgery and intraoperative electron radiotherapy (RT) as a boost followed by whole-breast RT in the past circa 5 years and completed the full RT dose at least 1 year before were included into this retrospective study. The patients who received prophylactic pentoxifylline (n=44) were assigned to Group A, and those who did not (n=38) to Group B. All cases were evaluated a month (early) and 1 year (late) later, scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management, Analytic scale and analyzed using an independent t-test. RESULTS In Group A, the score was 0,1, 2, and 3 in 24,11,seven, and two cases, respectively, in the early period and in 26,10, five, and three cases, respectively, in the late period. In Group B, the score was 0,1, 2, and 3 in 20,10, five, and three cases, respectively, in the early period, and in 15, 12, six, and five cases, respectively, in the late period. The average scores in Groups A and B were, respectively, 0.90/0.86 in the early and 0.65/1.02 in the late period. According to the t-test, there was a significant difference in the late period (p=0.001) in favor of Group A. CONCLUSION Penthoxifylline was effective in protection against the radiation injury.

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“…80,81 Acute radiodermatitis does not appear to improve with the use of pentoxifylline. 82,83 Pentoxifylline has often been studied in combination with another antioxidant: tocepherol (vitamin E).…”

Section: Pentoxifylline and Tocepherolmentioning

confidence: 99%

The Use of Antioxidants in Radiotherapy-Induced Skin Toxicity

2013

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Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.

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Pentoxifylline Effects on Acute and Late Complications after Radiotherapy in Rabbit

Cited by 10 publications

References 9 publications

Wound healing in radiated skin: pathophysiology and treatment options

Wound healing in radiated skin: pathophysiology and treatment options

Effect of Pentoxifylline in Protection the Breast Tissue Against Radiation Injury

The Use of Antioxidants in Radiotherapy-Induced Skin Toxicity

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