Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: A phase II clinical trial

Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways

“…Recently, PTX has been of interest in radiation oncology for the improvement of tumor perfusion and tumor oxygenation [9][10][11][12]. In several clinical and experimental studies, PTX was also shown to diminish the severity of late radiation injury, however, it remains to be shown whether PTX is beneficial in the prevention of early radiation injury [12][13][14][15][16][17][18][19][20].…”

Skin Surface, Dermis, and Wound Healing

“…Delanian et al reported on 43 patients treated with pentoxifylline (800 mg per day) and vitamin E (1000 U per day) for 6 months, and found decreased area of fibrosis, and improved symptoms (Delanian et al 1999). A decrease in the area of fibrosis has been similarly reported in other small series (Haddad et al 2005;Futran et al 1997). Randomized trial results are promising, but not definitive, however.…”

Recent Concepts of Etiopathogenesis and Management of Oral Submucous Fibrosis: A Review of Literature

“…Haddad et al treated 34 radiation induced superficial fibrotic lesions of skin with Pentoxifylline and vitamin E for 3 months and reported a significant improvement in radiation induced fibrosis. [71] Rawlins et al reported that Pentoxifylline has a direct effect on inhibiting burn scar fibroblasts. [72] Extrapolating this finding, the drug has been also used to alleviate the symptoms in patients with OSMF.…”