Pentazocine and Aspirin for Pain Following Oral Surgery

Abstract

Abstruct:In a double-blind clinical study, a comparison was made of pentazocine, aspirin and placebos, in varying dosage levels, following oral surgery. These were administered orally to 378 patients during the first 24 hours following surgical removal of impacted mandibular third molars. The patients were divided into eight groups which were found to' be homogeneous with respect to age, sex, weight and eruptive state of the tooth involved. They were given pentazocine at four dose levels and aspirin and placebos at three dose levels. In all 60 patients had no pain during the 24 hours following surgery.There were no significant differences in between the results among the eight patient groups, with regard to which drug they had received. The majority of patients slept well. However, patients who received aspirin slept significantly better than those receiving pentazocine or placebos. Of 136 patients reporting side effects, there were significantly more complaints from the patients taking pentazocine than from those treated with aspirin or placebos.

Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies

“…There were 17 citations [14–30] with relevant direct comparisons (18 trials) of more than one dose of aspirin. There were four comparisons of 500 and 1000 mg and 10 of 600 or 650 g and 1000 or 1200 mg. Other comparisons included doses of 200, 300, 325, 625, 650, 750 and 900 mg.…”

“…At the second level of analysis eight trials [14, 17, 18, 21, 22 (two studies), 23, 28] had extractable data. The size of the comparisons varied from 21 to 250 patients, with an average of 114 patients and median of 89 patients.…”

“…Of the six other dose comparisons, three showed numerically greater efficacy with the higher dose. Only two of 18 comparisons reported a statistically significant difference between two doses of aspirin, one [20] showing more effect with 650 mg than 325 mg, while another [23] demonstrated a difference only between 1200 mg and 300 mg, but not between 1200 and 600 mg. At the second level of analysis eight trials [14,17,18,21,22 (two studies), 23, 28] had extractable data. The size of the comparisons varied from 21 to 250 patients, with an average of 114 patients and median of 89 patients.…”