Pentathiepins and trithianes from two Lissoclinum species and a Eudistoma sp.: inhibitors of protein kinase C

Synthesis and antiproliferative properties of a new ceramide analog of varacin

“…Benzopolysulfanes are a unique class of compounds, some isolated from marine tunicates or their associated microorganisms, e.g, varacin ( 2 ), lissoclinotoxin A ( 3 ), and N,N -dimethyl-5-(methylthio)varacin ( 4 ) (Davidson et al, 1991; Litaudon and Guyot, 1991; Compagnone et al 1994; Searle and Molinski, 1994; Makarieva et al, 1995; Liu et al 2004a; Liu et al 2004b; Bentley, 2005; Tachibana et al 2005; Jiang et al, 2012). Common to these natural polysulfane structures is a dopamine core (Ford et al, 1994; Toste and Still, 1995; Molinski, 2004), although synthetic analogs have been prepared (Konstantinova et al 2004; Konstantinova et al, 2012; Okuma et al, 2012; Zubair et al, 2013; Koyioni et al 2014).…”

Cytotoxicity of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, against Human Solid-Tumor-Derived Cell Lines

“…Aromatic alkaloids possessing polysulfide structures have been reported from ascidians of the genera Lissoclinum, 1,2,[4][5][6][7][8][9] Eudistoma, 7) and Polycitor. 10) There is only one example of a trimer, lissoclibadin 1 (1), 1,2) and six dimeric polisulfides 2,5,8,11) and more than 10 monomeric cyclic polysulfides [4][5][6][7]9,10) have been isolated from the above ascidians.…”

“…10) There is only one example of a trimer, lissoclibadin 1 (1), 1,2) and six dimeric polisulfides 2,5,8,11) and more than 10 monomeric cyclic polysulfides [4][5][6][7]9,10) have been isolated from the above ascidians. Various biological activities, such as antifungal activity, 2,[4][5][6]10) antibacterial activity, 2,7,10) cytotoxicity, 2,4,6,11) antimalarial (Plasmodium falciparum) activity, 6) inhibition of protein kinase C, 7,8) and inhibition of IL-8 Ra and Rb receptors 9) have been reported.…”

Characterization and online detection of aromatic alkaloids in the ascidian Lissoclinum cf. badium by liquid chromatography/UV detection mass spectrometry

“…18 More than ten monomeric cyclic polysulfides [12][13][14][15]17,18 and four dimeric polysulfides 13,16,19 have been reported. These compounds presented various biological activities, for example, antifungal activity, [12][13][14]18 antibacterial activity, 14,18 cytotoxicity, 12,14,19 antimalarial (Plasmodium falciparum) activity, 14 inhibition of protein kinase C, 15,16 and inhibition of IL-8 Ra and Rb receptors. 16 The unique structure and potential of bioactivities of aromatic polysulfide alkaloids has attracted much attention from chemists and biologists.…”