Pentapeptide sharing betweenCorynebacterium diphtheriatoxin and the human neural protein network

Abstract

We describe the pentapeptides shared between the Corynebacterium diphtheria toxin and the human proteins associated with fundamental neural functions. We report that diphtheria toxin pentapeptides are spread among human antigens such as tuberous sclerosis proteins 1 and 2, reelin, contactin-4, neuroligins, semaphorin-5A, sodium channel protein type 1 subunit α, Williams-Beuren syndrome chromosomal region 1 protein, Williams-Beuren syndrome chromosomal region 20A protein. Williams-Beuren syndrome chromosomal region 8 protein, Bardet-Biedl syndrome 9 protein, Bardet-Biedl syndrome 10 protein, oligodendrocyte-myelin glycoprotein, neurofibromin-2, and periaxin. The data are discussed in relation to the bacterial immune escape phenomenon, and in the context of potential cross-reactions in diagnostic tests and immune therapies.

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

“…For diverse pathogens, these human homologues appear to be concentrated within networks that are relevant to diseases in which the pathogen is implicated [35, 37, 38, 179, 180]. This problem is extensive and concerns all human proteins, along their entire length.…”

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders

“…Recent studies have shown that the human proteome contains multiple sequences (pentapeptides or longer contiguous or gapped consensus) identical to those within numerous viral and microbial proteins, with the human matches concentrated within networks relevant to diseases in which the pathogen is implicated (Kanduc et al, 2008;Bavaro et al, 2011;Trost et al, 2011). This phenomenon concerns all human proteins.…”

Peptide Sharing between Bordetella Pertussis Proteome and Human Sudden Death Proteins: A Hypothesis for a Causal Link

“…Microbial proteomes massively overlap human proteins [34][35][36][68][69][70] in a tight network of metabolic interactions that may carry pathologic sequelae in the host. Indeed, bacterial organisms may interfere with the apoptotic apparatus [71], manipulate and subvert host-cell pathways [72], and interfere with the host immune system and mechanisms [73].…”

“…In general, microbial-versushuman cross-reactions are expected phenomena in infections. Indeed, numerous reports highlight a high level of microbial-versus-human peptide overlap [34][35][36], and B. pertussis is no exception. In fact, it was found that the number of B. pertussis pentapeptide occurrences in the human proteome (including multiple occurrences) is 6,271,766, with 35,998 human proteins involved in the pentapeptide overlap [35].…”