Pentalogy of Cantrell in Full Term Neonate

Taee, Nadereh; Goodarzi, Mojgan Faraji; Safdari, Mohammad; Bajelan, Amir

doi:10.1055/s-0039-1683936

Cited by 5 publications

(4 citation statements)

References 7 publications

(11 reference statements)

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“…PC is a rare congenital malformation, which was first reported by Cantrell in 1958 and revised by Toyama in 1972 ( 2 ). PC can be diagnosed by ultrasound in early pregnancy ( 3 ). Prenatal diagnosis helps families to make an informed decision on whether to continue pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…The severity of the disease varies accordingly. In some cases, the heart protrudes beyond the chest and abdomen, as if the heart is beating outside the body, especially in patients with omphalocele and abdominal fissure ( 3 ). There are many kinds of deformities in this reported case, which are consistent with the manifestation of complete PC.…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate of patients with cardiac heterotopia was as high as 52% ( 9 ), and the main causes were cardiac rupture, tamponade, cardiac arrest, endocarditis, vascular embolism, heart failure and arrhythmia ( 3 , 9 ). The prognosis of patients with severe complete PC is poor, the average survival time without surgical intervention is about 36 hours ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

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Surgical treatment of neonatal Cantrell pentalogy: a case report and literature review

Liao¹,

Huang²,

Li³

2023

AME Case Rep

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Background Pentalogy of Cantrell (PC) is a congenital multiple malformation consisting of midline supraumbilical thoracoabdominal wall defects, anterior and pericardial diaphragm defects, lower sternum defects, ectopia cordis and various intracardiac anomalies, that present a distinctive challenge for care-providers and surgeons. Case Description Cases of PC in twin pregnancies is rare. We report a new born infant, weighing 2,400 g, the younger twin. After birth, he was transferred to the Children’s Hospital of Soochow University due to the prenatal echocardiography indicated that he has ventricular septal defect (VSD), atrial septal defect (ASD) and aortic arch hypoplasia. From the appearance, the lower end of sternum is suspiciously missing, the apical beating point is located at the lower edge of the median xiphoid process of sternum, and the upper abdominal muscle below the beating area is defective. He has the clinical and imaging features of complete type of PC. Three surgical operations were performed in the neonatal period, including end-to-side anastomosis of aortic arch under cardiopulmonary bypass (CPB), patch repair of VSD, repair of ASD, ligation of ductus arteriosus, correction of cardiac vascular malformation and repair of chest and abdominal wall defect, and the postoperative recoveries went smoothly. Conclusions PC is a rare congenital dysplasia, and its condition is complex. Our case shows that surgery is an effective treatment method, and the prognosis is related to the complexity of malformations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Surgical treatment of neonatal Cantrell pentalogy: a case report and literature review

Liao¹,

Huang²,

Li³

2023

AME Case Rep

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“…The prevalence of hypothyroidism is reported with great variability due to geographical and ethnical variations, screening protocol of thyroid hormone and genetic diversity. Its prevalence in Iran is reported higher than other regions [ 7 ]. A cross-sectional study conducted in the central part of Iran on more than 400,000 neonates reported that the prevalence transient congenital hypothyroidism is this region is 1 in 294 live births [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of transient congenital hypothyroidism among neonates

Alavi

Rafiei

et al. 2021

Annals of Medicine and Surgery

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Objective Persistence of low levels of thyroid hormone from the time of birth is one of the significant causes of the mental retardation. The aim of this study was to determine the prevalence of transient congenital hypothyroidism among neonates in (XXX). Methods This cross-sectional study, neonates aged 3–5 days who were referred to our center for checkup were screened for thyroid stimulating hormone. Those with TSH < 5mIU/l were, infants were subjected to retesting after one week for TSH and T4 levels. A questionnaire consisting of test results, demographic characteristics, place of sampling, gender, need for re-sampling after the second week for TSH level, birth weight, type of hypothyroidism and prematurity was filled for all the neonates. Results Of 3600 neonates screened, 126 were presented with had TSH above 5 mIU/l, of which 7 had high TSH and low T4 and were diagnosed with transient hypothyroidism (5.3%). The mean weight of the neonates with hypothyroidism of significantly lower, p = 0.001. However, the type of delivery was not associated with the prevalence of hypothyroidism, p = 0.999. The relationship between maternal hypothyroidism, preterm birth and intake of antithyroid drugs and transient hypothyroidism was statistically significant, p < 0.001, respectively. Conclusions The incidence of congenital hypothyroidism was 1 in 514 births and was significantly associated with preterm birth, mean weight, maternal hypothyroidism and intake of antithyroid drugs. Routine screening in high prevalence regions are therefore importance, considering the associated factors.

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Incomplete pentalogy of Cantrell: a case report and review

Kagantsov

Bairov

Гиреевич³

et al. 2021

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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BACKGROUND: The pentalogy of Cantrell is a rare congenital malformation characterized by five component defects in the anterior abdominal wall, lower sternum, anterior diaphragm, and diaphragmatic pericardium and congenital heart disease. The occurrence of the five features is quite rare. The pentalogy of Cantrell is classified as complete, partial, and incomplete. Few studies have described the successful treatment of neonates with the pentalogy of Cantrell, with even fewer publications about an incomplete defect. CASE REPORT: We report the successful surgical treatment of a newborn boy with an incomplete pentalogy of Cantrell. In this patient, the diaphragmatic hernia was eliminated at the first stage, and a temporary container for umbilical cord hernia was made by suturing the silastic sac to the edges of the defect in the anterior abdominal wall for subsequent gradual immersion of the hernia contents into the abdominal cavity. These steps made it possible to reduce intra-abdominal and, accordingly, intrathoracic pressures, provide favorable conditions for the healing of the diaphragm, and thus stabilize the childs respiratory and cardiovascular systems. Subsequently, the cardiovascular system was examined under more favorable conditions and intracardiac defects were excluded. Moreover, the proposed technique made it possible to safely perform the second stage of surgical correction, i.e., radical plasty of the anterior abdominal wall on day 14 of life with full restoration of the normal anatomical and physiological relationships, by which time the diaphragm and mediastinum had taken their correct topographic position. The literature review provides data from 32 sources. CONCLUSION: The pentalogy of Cantrell is a severe congenital malformation with a high risk of poor outcomes. Reporting of all possible variants of the pentalogy of Cantrell (complete, partial, or incomplete), regardless of the outcome, is important for the accumulation of experience in treating such patients, which by focusing on the clinical situation and the combination of various defects in the pentalogy of Cantrell will improve the strategy and prognosis for this defect.

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Pentalogy of Cantrell in Full Term Neonate

Cited by 5 publications

References 7 publications

Surgical treatment of neonatal Cantrell pentalogy: a case report and literature review

Surgical treatment of neonatal Cantrell pentalogy: a case report and literature review

Prevalence of transient congenital hypothyroidism among neonates

Incomplete pentalogy of Cantrell: a case report and review

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