Pentagastrin-Infusion Test After Atropine or Vagotomy

Rowlands, C.A.; Temperley, J. M.; Wyllie, J. H.

doi:10.1016/s0140-6736(69)92700-7

Cited by 9 publications

(1 citation statement)

References 9 publications

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“…One circle: p < 0 05. Two circles: P < 0-02. mine effects on gastric and pancreatic secretions were based on previous works demonstrating that the recovery of basal gastric juice is constant after 45 minute aspiration (Christensen and Stadil, 1976), that the gastric acid secretion reaches a constant rate after 15 minute pentagastrin infusion, and is maintained for two more hours (Rowlands et al, 1969) and that pancreatic secretion achieves constant levels after 20 minute continuous hormonal stimulation (Tympner et al, 1974). The present study shows that dopamine infusion at the dose of 4 ,ug/kg-min for one hour significantly lowers basal and pentagastrin-stimulated gastric acid secretion, effects which were abolished by pretreatment with metoclopramide, a relatively specific~1 dopamine receptor antagonist (Peringer et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.

Caldara¹,

Ferrari²,

Romussi³

et al. 1978

Gut

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SUMMARY The effect of dopamine infusion on basal and pentagastrin-stimulated gastric secretion, on basal and secretin-CCK-PZ-stimulated pancreatic secretion, and on basal and meal-induced gastrin release has been evaluated in healthy volunteers. Both basal and stimulated gastric acid secretion were significantly inhibited during dopamine infusion with a significant rebound to preinfusion values after discontinuing dopamine. These effects were prevented by pretreatment with the antidopaminergic drug, metoclopramide. A slight but not significant decrease in amylase and bicarbonate outputs was also observed during dopamine infusion, while gastrin release did not change. These data suggest the existence of dopaminergic mechanisms in the regulation of gastric acid secretion in man.

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Section: Discussionmentioning

confidence: 99%

Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.

Caldara¹,

Ferrari²,

Romussi³

et al. 1978

Gut

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Physiologie

Demling¹

1974

Magen

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Effect of sulpiride isomers on gastric acid and gastrin secretion in healthy man

Caldara

Masci

Cambielli

et al. 1983

Eur J Clin Pharmacol

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The effects of the antidopaminergic drug sulpiride on gastric acid secretion and gastrin release have been evaluated in 42 healthy individuals. Basal and submaximal pentagastrin (0.5 micrograms/kg-h)-stimulated gastric acid secretion, as well as basal and meal-induced gastrin secretion, were studied after acute intramuscular administration of racemic sulpiride (100 mg) and its L-(50 mg) D-(50 mg) isomers. Racemic and L-sulpiride significantly decreased stimulated serum gastrin concentration, but they did not affect fasting serum gastrin or basal and stimulated gastric acidity. D-sulpiride significantly decreased gastric acid secretion, without affecting serum gastrin levels. While the effects of racemic and L-sulpiride are analogous to those of other antidopaminergic drugs, D-sulpiride mimics the action of dopamine, at least at gastric level. These data support the hypothesis that the D-isomer may possess agonist-antagonist activity at dopamine receptors. Since racemic sulpiride has been used with conflicting results in the therapy of patients with peptic ulcer, in the light of the present results it would be of interest to study separately the efficiency of the D- and L-isomers of the drug in healing peptic ulcer.

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Pentagastrin-Infusion Test After Atropine or Vagotomy

Cited by 9 publications

References 9 publications

Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.

Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.

Physiologie

Effect of sulpiride isomers on gastric acid and gastrin secretion in healthy man

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