Pentacyclic triterpenoids and sterols from seven species of mangrove

Ghosh, Amitabha; Misra, Suniti; Dutta, A. K.; Choudhury, A.

doi:10.1016/s0031-9422(00)82541-8

Cited by 121 publications

(58 citation statements)

References 9 publications

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“…Structures of three compounds isolated from the hexane and chloroform extracts of leaves of S. Hydrophyllacea were elucidated by means of 1 H-and 13 C-NMR data and the compounds were identified as oleanolic acid (compound 1), ursolic acid (compound 2) and eichlerianic acid (compound 3). Although isolation and structure elucidation of ursolic acid and oleanolic acid from several other mangrove varieties has been reported [16,17], this is the first report on the isolation eichlerianic acid from S. Hydrophyllacea leaves. Cytotoxicity results from the cytotoxic assays demonstrated that, among the three compounds ursolic acid and eichlerianic acid exerted strong cytotoxic effects on non-small lung cancer cells (NCI-H292) and oestrogen receptor positive (MCF-7) breast cancer cells at 24, 48 and 72 h post incubation periods.…”

Section: Discussionmentioning

confidence: 90%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

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and two-dimensional nuclear magnetic resonance (2D-NMR) and electron ionization-mass spectrometry (EI-MS) techniques. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxic effects of the compounds on oestrogen receptor positive breast (MCF-7) and non-small cell lung (NCI-H-292) cancer cells. Results: The isolated compounds were identified as oleanolic acid (1), ursolic acid (2) and eichlerianic acid (3). Ursolic acid and eichlerianic acid showed strong cytotoxic effects {IC50-ursolic acid: 8.47 µg/mL (24 h, MCF-7), 7.78 µg/mL (24 h, NCI-H292) and eichlerianic acid: 8.86 µg/mL (24 h, MCF-7), 10.15 µg/mL (24 h, NCI-H292)} in MCF-7 and NCI-H292 cancer cells at 24, 48 and 72 h post-incubation periods. Conclusion: Hexane and chloroform extracts of the leaves of S. hydrophyllacea yielded three compounds namely oleanolic acid, eichlerianic acid and ursolic acid. Ursolic acid and eichlerianic acid have been isolated for the first time from the leaves of S. hydrophyllacea grown in Sri Lanka and demonstrate in-vitro cytotoxic effects in oestrogen receptor positive (MCF-7) and non-small lung cancer (NCI-H-292) cells.Keywords: Scyphiphora hydrophyllacea, eichlerianic acid, ursolic acid, oleanolic acid, This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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Section: Discussionmentioning

confidence: 90%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

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“…albida yielded one new iridoid glucoside, 6′-O-Ecaffeoyl-mussaenosidic acid 1 , the iridoid glucoside 6′-O-Ecaffeoylcatalpol 14 , one known iridoid aglycon, rehmaglutin 15 and one known flavonoid, 4′-hydroxywogonin-7-O-β-D-glucuronic acid glycoside 16 . Also, the acetonic extract, offered four known triterpenes, stigmasterol 17 , β-sitosterol 18,19 , betulin 20 , and betulinic acid 20,21 . The plant material has been extracted as previously described 2 .…”

Section: Extraction and Isolationmentioning

confidence: 99%

Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp.

Gousiadou

Gotfredsen

Matsa

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…typical. These plants are valued for their rich tannin content and are a rich source of pentacyclic triterpenoids 17 . To date, 30 metabolities from C. decandra and 72 metabolites from C. tagal are known.…”

Section: Ceriopsmentioning

confidence: 99%

Metabolites and bioactivities of Rhizophoraceae mangroves

Murukesh

Harisankar

Chandramohanakumar

2013

Nat. Prod. Bioprospect.

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This review examines the chemical compositions and bioactivities of mangrove plants belonging to the Rhizophoraceae family. The Rhizophoraceae family of true mangrove plants is the most common and is also widely distributed species. It consists of 24 species across four genera. Of the 24 species, 12 species remain unexamined for their phytochemical constituents. There have been 268 metabolites reported from 16 species. The key phytochemical constituents identified across the family are the diterpenoids and triterpenoids. The major diterpenoids include pimaranes, beyeranes, kaurenes, dolabranes and labdanes whereas the significant triterpenoids are lupanes, dammaranes and oleananes. Disulphides, dolabranes and labdanes are considered to be the chemotaxonomic markers of the genera Bruguiera, Ceriops and Rhizophora respectively.

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Pentacyclic triterpenoids and sterols from seven species of mangrove

Cited by 121 publications

References 9 publications

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp.

Metabolites and bioactivities of Rhizophoraceae mangroves

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