Pentachlorphenol und Leberfunktion: Eine Untersuchung an beruflich belasteten Kollektiven

Zober, A.; Kh, Schaller; Goßler, K.; Hj, Krekeler

doi:10.1007/bf00378683

Cited by 24 publications

(2 citation statements)

References 5 publications

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“…This study was designed to measure the prevalence of persistent effects years after exposure and not the incidence of reversible health effects during or shortly after exposure. Our primary hypotheses included those health effects that some investigators have reported in dioxin-exposed individuals many years after exposure, specifically chloracne (4,8-10,29-38), liver dysfunction (6,20,31,33,35,39), disorders of porphyrin metabolism (10,35,37,40,41), neurobehavioral disturbances (35,36,(42)(43)(44)(45), disorders of lipid metabolism (32,35,43,46,47), and peripheral neuropathy (4,5,10,31,35,42,(48)(49)(50)(51). The analyses in this paper focus on general health status, chloracne, and disorders of porphyrin metabolism.…”

Section: Discussionmentioning

confidence: 99%

A morbidity study of former pentachlorophenol-production workers.

Hryhorczuk

Wallace

Persky

et al. 1998

Environ Health Perspect

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Pentachlorophenol (PCP) is a pesticide that was once widely used for wood preservation. Commercial PCP contained impurities including higher chlorinated dibenzo-p-dioxins (CDDs) and chlorinated dibenzofurans (CDFs). We investigated the effects of occupational exposure to PCP and its CDD and CDF contaminants on the skin, liver, porphyrin metabolism, and central and peripheral nervous systems. In 1986 we conducted a medical survey of 366 workers who had been engaged in the production of PCP at a single plant between 1938 and 1978. The referent group consisted of 303 workers from the same plant who were not exposed to these or related compounds. Exposure was determined from computerized personnel records. The medical survey included an administered questionnaire, medical record review, physical examination by dermatologists, internists, and neurologists, and analysis of 24-hr urine for quantitative porphyrins among other tests. In this paper we present the results of analyses of the general health, chloracne, and porphyrin metabolism end points. The general health status of PCP workers was similar to unexposed workers, but 17.8% of PCP workers had evidence of current or past chloracne. PCP workers with chloracne had significantly higher mean urinary excretion of coproporphyrins (117. 0 vs. 90.6 microg/24 hr) than unexposed workers after controlling for potential confounders. Workers with chloracne who had worked with both PCP and polychlorinated biphenyls had significantly higher mean urinary excretions of hepta-, penta-, and coproporphyrins than unexposed workers. We conclude that occupational exposure to PCP is associated with chloracne and biochemical abnormalities which may persist years after exposure.

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Section: Discussionmentioning

confidence: 99%

A morbidity study of former pentachlorophenol-production workers.

Hryhorczuk

Wallace

Persky

et al. 1998

Environ Health Perspect

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“…Investigations at the workplace have shown that the first toxic effects of long-term exposure become apparent at concentrations of between 300 and 4000 µg PCP per litre serum [13,16,17]. Thus a BAT value of 1000 µg per litre serum or 300 µg per litre urine was assigned by the MAK Commission [3].…”

Section: Pentachlorophenolmentioning

confidence: 99%

Pentachlorophenol [Biomonitoring Methods, 1999]

Hoppe¹

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Analyses of Hazardous Substances in Biological Materials , Vol. 6 (1999) The article contains sections titled: General principles Equipment, chemicals and solutions Equipment Chemicals Solutions Calibration standards Specimen collection and sample preparation Operational parameters for gas chromatography/mass spectrometry Analytical determination Calibration Calculation of the analytical result Standardization and quality control Reliability of the method Precision Accuracy Detection limit Sources of error Discussion of the method

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Phenol and Phenolics

Cavender,

O'Donoghue

2023

Patty's Toxicology

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The phenolics used for industrial and commercial purposes are a large and diverse group of chemicals as the six‐member ring of phenolics can be methylated, halogenated or include other moieties that add properties or toxicological potential that is not observed with simple phenolics. For simple dihydroxy phenolics, the largest exposure potential can be through their presence naturally in foods. Low concentrations of chlorophenols are commonly found in drinking water due to water chlorination processes. Simple methyl phenols are commonly used as disinfectants. More complex phenolics such as creosote and pentachlorophenol are used as wood preservatives. The acute toxicity of phenolics at relatively high doses is manifested as excitation of the nervous system causing muscle tremors, salivation, and in severe cases, convulsions. The excitatory phase of phenolic intoxication gives way to depression of the nervous system and can result in mortality. Acute and repetitive exposure to phenolics can result in liver and kidney toxicity. A number of phenolics can be absorbed through skin and are readily absorbed after ingestion. Major metabolites of phenols are sulfates and glucuronide conjugates that are excreted through the kidneys. First pass metabolism present on ingestion is not a factor for phenols absorbed through the skin. Therefore, the toxicity of phenolics may differ depending on route of exposure.

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Pentachlorphenol und Leberfunktion: Eine Untersuchung an beruflich belasteten Kollektiven

Cited by 24 publications

References 5 publications

A morbidity study of former pentachlorophenol-production workers.

A morbidity study of former pentachlorophenol-production workers.

Pentachlorophenol [Biomonitoring Methods, 1999]

Phenol and Phenolics

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