Pentachlorophenol causes redox imbalance, inhibition of brush border membrane and metabolic enzymes, DNA damage and histological alterations in rat kidney

Maheshwari, Nikhil; Khan, Aijaz Ahmed; Mahmood, Riaz

doi:10.1016/j.pestbp.2022.105318

Cited by 11 publications

(4 citation statements)

References 65 publications

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“…This compound increased DNA fragmentation and the formation of intense bands (ladder) marking apoptotic damage in kidney cells. Data from published studies have linked pesticide administration to increased DNA fragmentation and therefore genotoxicity in the kidney [45,46]. Conversely, E. alata treatment at a dose of 40 mg/kg significantly attenuated the observed genotoxicity and decreased the alteration of the DNA profile induced by acephate exposure.…”

Section: Discussionmentioning

confidence: 99%

Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

Mufti,

Feriani,

Contreras

et al. 2023

Life

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The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that E. alata inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of E. alata in renal tissue. Additionally, the immunofluorescence study showed the upregulation of LC3 gene expression, suggesting the capacity of E. alata extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in E. alata, has a higher affinity toward the Na+/K+-ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that E. alata seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities.

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Section: Discussionmentioning

confidence: 99%

Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

Mufti,

Feriani,

Contreras

et al. 2023

Life

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“…253,254 Alternatively, dimethoate and pentachlorophenol (PCP) are widely used organophosphate and organochlorine pesticides, respectively, which accumulate in the ecosystem (soil, water, and agriculture products) and cause adverse toxicological impacts in humans and other living beings. 255,256 In this case, a CD/AgNP-based uorometric platform was developed using N,S-CDs (sheep wool derived) for the highly sensitive and selective determination of glyphosate. The uorescence quenching of CDs by AgNPs (turn-off), and its subsequent recovery (turn-on) in the presence of glyphosate are due to the IFE and IFE inhibition, respectively.…”

Section: Sensor Applicationmentioning

confidence: 99%

An overview on animal/human biomass-derived carbon dots for optical sensing and bioimaging applications

Dubey

2023

RSC Adv.

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“…Pentachlorophenol (PCP) is considered one of the most toxic organochlorines due to its biocidal properties, posing significant risks to various soil and water organisms [ 2 ]. Even at low concentrations, such as 1 mg/L, PCP can adversely affect aquatic invertebrates (mollusks, crustaceans) and vertebrates (fish) in acute toxicity tests [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

MnO2/TiO2-Catalyzed ozonolysis: enhancing Pentachlorophenol degradation and understanding intermediates

Valdés,

Quispe,

Fritz

et al. 2024

BMC Chemistry

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Pentachlorophenol is a pesticide widely known for its harmful effects on sewage, causing harm to the environment. In previous studies, our group identified adsorption as a crucial factor in catalytic ozonation processes, and subsequent observations revealed the catalyst’s role in reducing toxicity during degradation. In this research, we quantified organochlorine intermediates and low molecular weight organic acids generated under optimal pH conditions (pH 9), with and without the catalyst. Additionally, we assessed the reactivity of these intermediates through theoretical calculations. Our findings indicate that the catalyst reduces the duration of intermediates. Additionally, the presence of CO2 suggests enhanced mineralization of pentachlorophenol, a process notably facilitated by the catalyst. Theoretical calculations, such as Fukui analysis, offer insights into potential pathways for the dechlorination of aromatic molecules by radicals like OH, indicating the significance of this pathway.

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Pentachlorophenol causes redox imbalance, inhibition of brush border membrane and metabolic enzymes, DNA damage and histological alterations in rat kidney

Cited by 11 publications

References 65 publications

Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

An overview on animal/human biomass-derived carbon dots for optical sensing and bioimaging applications

MnO2/TiO2-Catalyzed ozonolysis: enhancing Pentachlorophenol degradation and understanding intermediates

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