Penile Ossification and Acquired Penile Deviation

Local lnterferon-Alpha2b Is Not an Effective Treatment in Early-Stage Peyronie's Disease

“…Subsequently, fibrosis occurs, which then may lead to calcification and ossification. Ossification has been observed in up to 25% of patients [2,3]. The cav ernous smooth muscle next to the plaque is replaced by collagenous tissue; the disease can obviously also develop deeper in the cavernous body, as also shown in 1 of our patients [26].…”

“…Microtrauma, sustained during intercourse and 'repaired' in a false manner, is generally suggested [2]. Clinically, association with Dupuytren's contracture reached statisti cal significance, others failed (tympanosclerosis, plantar fibrosis, diabetes mellitus, osteoarthritis, gout, arterioscle rosis, ß-blocker and methotrexate medication [3,19]. Autosomal dominant traits have been suggested [20] Histologically, Peyronie's disease is characterized by a progressive vasculitis which starts as a perivascular in flammatory infiltrate in the loose connective tissue sleeve between the tunica albuginea and the sinusoids of the cor pora cavernosa.…”

“…Since all conservative therapies have failed, therapy today is still surgical, even though it leads to penile shortening Induratio penis plastica, named Peyronie's disease af ter François de la Peyronie (1678-1747), usually afflicts men in their fifties. It is characterized by fibrous plaques within the tunica albuginea, which can calcify and even ossify and cause penile deviation [1][2][3], The plaques can be painful, and intercourse can be impossible because of the deviation or vascular factors [4,5]. Peyronie's disease KARGER.…”

Detrusormyectomy (autoaugmentation) in the treatment of hyperreflexive low-compliance bladder

“…Couvelair [11] hat dies für eine andere Indikation (einen funktionellen, nicht mehr aktiven, fibrotisch alterierten Detrusor) vorgeschlagen. Andere Versuche einige Jahre später, bei Malignomen das Trigonum stehen zu lassen und eine extraperitoneale Höhle als Speichersystem zu benutzen [56], führten zwar zu erstaunlichen Frühergebnissen (250 ml ¹Kapazitätª), waren aber letztlich unbefriedigend. Gonzales [29] hat uns auf diese interessante Publikation aufmerksam gemacht.…”

Penile ossification: a model radiological presentation

“…Human penile ossification is a rare finding; less than 15 histologically confirmed cases have been described [ 2]. The aetiology of bone formation in the human penis is still unclear.…”