Penile metastases of rectal adenocarcinoma after abdominoperineal resection: a case report

Marghich, Omar; Dkhissi, Younes; Alila, Mohammed; Bouhaddouti, Hicham El

doi:10.1186/s13256-019-2147-z

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…In 40% of patients, priapism is considered a prominent feature. Metastases can present as plaques, wart-like nodules, ulceration, erythema, or induration of the penis ( 5 ). The mass ordinarily progresses to involve the corpora cavernosa with extension into the neighboring perineal subcutaneous tissue, the corpus spongiosum, and bulb ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…Boubacar Efared et al disclosed a patient with penile metastasis from rectal adenocarcinoma who accepted his adjuvant chemotherapy (XELOX regimen, oxaliplatin plus capecitabine) ( 4 ). A patient underwent palliative chemotherapy treatment and still alive 4 months after diagnosis of penile metastases ( 5 ). Lee et al reported a patient with metastatic carcinoma from the rectal cancer and the patient was still alive after receiving palliative chemotherapy with modified FOLFOX-6 (mFOLFOX-6; oxaliplatin with 5-fluorouracil and folinic acid) plus bevacizumab ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

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Background Despite the rich proximity and vascularization to the pelvic organs, metastatic lesions to the penis are incredibly uncommon. Most primary tumors are genitourinary cancers, and rectal origins are rare. Only 56 cases of metastatic penile tumors have been reported since 1870. Several palliative or curative methods, such as chemotherapy, total penectomy, and radiotherapy, have been applied to treat this condition in previous cases; however, the patient prognosis is poor. Immunotherapy is a beneficial treatment approach for multiple cancers, and recent investigations have shown that it may be beneficial for patients with advanced penile cancer. Case Description Herein, we report the case of a 59-year-old Chinese man who had metastatic adenocarcinoma in the penile tissue 3 years after rectal cancer resection. The patient presented with penile pain and dysuria for 6 months when he was 54 years old, and Immunohistochemical staining showed that the origin was the rectum after total penectomy. The patient received surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy positively and still survived for a further 4 years and 6 months following penectomy despite the late metastasis of rectal cancer. There are two major changes and progress after penectomy, all of which have undergone surgical treatment during continuous treatment and follow-up, the patient completed right inguinal lymphadenectomy when his right regional nodes metastasis was found 23 months after penectomy. While the patient suffered from radiation injury after 47 months after penectomy, which led to radiation necrosis and hip soft tissue infection, and the patient tended to lay prone instead of lying on the back because of the hip pain. The patient ultimately died of multiple organ failure. Conclusions All of the previously reported cases of penile metastasis from rectal cancer since 1870 have been reviewed. Yet, the metastatic prognosis remains poor regardless of the treatment options, except for lesions where metastasis is only limited to the penis. We found that the patient may derive more benefit from strategic therapies including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

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“…Until now, only 6 cases of penile metastasis in the rectal cancer after neoadjuvant CRT have been reported. [ 3 – 9 ] Among these, 1 patient did not undergo surgery due to exacerbate multiple pulmonary metastasis and 1 patient received only short-course radiotherapy. Pathologic stages II and III were found in 3 patients each.…”

Section: Discussionmentioning

confidence: 99%

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

Lee¹,

Son

Kim³

et al. 2020

Medicine

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Rationale: Penile metastasis in rectal cancer is very rare and often originates from prostatic or bladder cancer. The prognosis of penile metastasis is poor and its treatments are more often palliative than curative due to association with disseminated metastases. Pathologic complete response (pCR) in rectal cancer with neoadjuvant chemoradiotherapy (CRT) has been shown to be surrogate marker of favorable long-term outcomes and currently has no report of penile metastasis. Here, we first report isolated penile metastasis in rectal cancer with pCR after neoadjuvant CRT. Patient concern: The patient was a 74-year-old male with metastasis to the glans penis from rectal cancer diagnosed 9 months after abdominoperineal resection. Physical examination revealed palpable multiple nodules on the glans penis. Diagnosis: Penile biopsy revealed metastatic carcinoma from the rectal cancer. Intervention: Chemotherapy was started as soon as possible, because patient suffered urinary discomfort by rapid growing metastatic lesions. He is currently receiving palliative chemotherapy with modified FOLFOX-6 (mFOLFOX-6; oxaliplatin with 5-fluorouracil and folinic acid) plus bevacizumab. Outcome: The patient is still alive 4 months after diagnosis with markedly decreased metastatic lesions. Lesson: We propose that although penile metastasis in rectal cancer with pCR after preoperative neoadjuvant CRT is extremely rare, it might help to start early palliative chemotherapy and clinicians should be aware of this possibility.

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“…. 4 Magnetic resonance imaging is the best non-invasive modality for the investigation of penile lesions and helps in assessment of tumor extent and involvement of the neighboring anatomic structures while USG and CT-scan can be helpful in diagnosis. Biopsy is required to differentiate metastasis form primary tumor.…”

Section: Discussionmentioning

confidence: 99%

Metachronous penile metastasis from carcinoma rectum: A case report

Phuyal

Thapa

Yadav

et al. 2020

Urology Case Reports

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Penile metastases of rectal adenocarcinoma after abdominoperineal resection: a case report

Cited by 5 publications

References 9 publications

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

Metachronous penile metastasis from carcinoma rectum: A case report

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