Penile Metastases From Prostate Adenocarcinoma: A Rare Presentation

Abstract

A 74-year-old male patient presented with acute urinary retention and sudden onset paraparesis, to the Emergency Department. Physical examination revealed multiple non tender nodules involving the glans and shaft of penis [Table/ Fig-1]. There were no palpable inguinal lymph nodes. Digital rectal examination revealed hard enlarged prostate with multiple nodules. Examination of the spine appeared normal. There was gross motor weakness including mild sensory loss involving both the lower limbs. Suprapubic cystostomy was performed to achieve urinary drainage.The patient had been previously diagnosed with locally advanced prostatic adenocarcinoma 4 years back at another institution and was started on hormonal manipulation. The patient had incomplete details about the previous histologic and radiologic findings. Considering the general status of the patient and the obvious clinical findings, was planned not to put the patient through multiple invasive procedures and focus was put on providing palliative care. On admission prostate specific antigen (PSA) was grossly elevated (227 ng/mL).The CT scan revealed features of prostate adenocarcinoma with no other gross abnormalities. Bulky growth involving the prostate with extracapsular extension and involves the seminal vesicles. No lymph node enlargement noted. In view of paraparesis, bone scan and MRI of spine were done which revealed multiple metastatic lesions involving the vertebrae and pelvic bones.A core biopsy of penile lesion was obtained for histopathology, which showed features suggestive of poorly differentiated adenocarcinoma [Table/ Fig-2]. Immunohistochemical staining for PSA was negative [Table/ Fig-3]. Similar presentation of penile metastases with PSA negativity was published. Diagnosis of penile metastases was considered because the clinical and imaging findings most likely matched metastatic prostatic adenocarcinoma and being previously diagnosed with prostate cancer. In view of general condition of the patient and poor prognosis, he was put on palliative care to improve his quality of life. On follow up, the patient had succumbed to the disease within 4 months. Metastatic penile tumours are extremely rare. DisCussionA search through the literature, 219 cases of penile metastases was identified, among which genitourinary cancers were the most common primaries [1]. Metastatic penile cancer from prostate adenocarcinoma was reported in very few cases. The most common presentations were nodules over penis, followed by priapism, pain during erection and dysuria in few cases. The following mechanisms have been described as causes of metastases to penis from prostate adenocarcinoma by Abehouse -direct invasion, implantation, haematogenous dissemination and lymhatic dissemination [2]. The prognosis remains poor in this group of patients. In one of the studies conducted in Japan, 71% of patients died within 6 months of such a diagnosis [3]. There are a number of treatment options aBstRaCt Penile metastases are rare in occurrence and are usually secondary to othe...

68Ga-PSMA-11 PET/CT and 64CuCl2 PET/CT Help in Identifying Rare Metastatic Site of Penile Shaft in a Patient of Carcinoma Prostate

“…2 There are a few case reports demonstrating this rare site of metastasis. [2][3][4] A few case reports in literature have reported the demonstration of the penile metastasis on PSMA PET/ CT scans. 5-9 64 CuCl 2 PET/CT imaging is under evaluation for imaging various oncological conditions including carcinoma prostate.…”

“…These patients have a poor prognosis receiving various treatment modalities 2 . There are a few case reports demonstrating this rare site of metastasis 2–4 . A few case reports in literature have reported the demonstration of the penile metastasis on PSMA PET/CT scans 5–9 .…”