Penile cancer – Incidence, mortality, and survival in Saxony, Germany

Schoffer, Olaf; Neumann, Anne; Stabenow, Roland; Schülein, Stefanie; Böhm, Wolf-Diether; Gonsior, Andreas; Horn, Lars‐Christian; Kriegel, Christian; Stolzenburg, Jens‐Uwe; Wirth, Manfred P.; Klug, Stefanie J.

doi:10.1016/j.urolonc.2018.12.003

Cited by 20 publications

(27 citation statements)

References 26 publications

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“…Among penile cancers, squamous cell carcinoma of the penis (SCCP) comprises the vast majority of cases 2,3 . According to reports, the 5‐year (5‐yr) overall survival of SCCP patients varies from 60% to 80% 3‐6 …”

Section: Introductionmentioning

confidence: 99%

Conditional survival after surgery for patients with penile cancer

et al. 2020

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Background Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. Objective To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. Materials and methods Patients with non‐metastatic SCCP were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Conditional 3‐yr overall survival (OS) rate and 3‐yr cancer‐specific survival (CSS) rate represented the primary outcomes of interest and were calculated using the Kaplan‐Meier method. The multivariable Cox regression model was employed to calculate proportional hazard ratios for the prediction of mortality. Results A total of 1887 SCCP patients who had undergone surgeries were identified. Given a 1‐, 2‐, 3‐, 4‐, and 5‐yr survivorship, the 3‐yr OS rates were, respectively, improved by + 9.8 (72.6%), +18.2 (78.1%), +23.4 (81.6%), +27.8 (84.5%), and + 26.6% (83.7%) from those calculated at baseline (time zero). As compared with the baseline calculations, patients who had survived 1, 2, 3, 4, or 5 yr after surgery could, respectively, harvest a + 7.8 (84.7%), +14.8 (90.2%), +19.5 (93.9%), +22.1 (96.0%), and + 22.4% (96.2%) improvement in 3‐yr CSS. Patients with the most aggressive disease at baseline ultimately benefited the most from event‐free survivorship. Multivariable Cox regression analyses showed that the impact of adverse pathological parameters (G2‐3, ≥ pT2, pN+) on OS and CSS mostly showed a decreasing trend over time and some could disappear after a minimum of 1‐yr survivorship. Discussion and conclusion The survival probability of SCCP patients increases with post‐operative survival. Patients with aggressive disease at baseline ultimately benefit the most from event‐free survivorship and may expect a better prognosis once they survive the critical few years after surgery. The recorded observations have crucial implications regarding patient counseling and follow‐up.

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Section: Introductionmentioning

confidence: 99%

Conditional survival after surgery for patients with penile cancer

et al. 2020

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“…Nuestro paciente tiene 65 años. El cáncer de pene es una enfermedad infrecuente, y se ha reportado entre los 60 y 79 años en el 63 % de los casos (7) .…”

Section: Discussionunclassified

¿Podría ser la diabetes factor de riesgo para cáncer de pene?: a propósito de un caso

Diaz-Meyzan

Lazo

2021

revista de salud udh

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El cáncer de pene es raro y afecta con mayor frecuencia a hombres mayores de edad. Reportamos el caso de un paciente varón con antecedente de tuberculosis y que, asimismo, padece diabetes mellitus (DM), quien presento cáncer a células escamosas de pene, siendo sometido a tratamiento quirúrgico satisfactorio. El artículo tiene el propósito de mostrar la posible relación entre la diabetes y el cáncer de pene, siendo esta una neoplasia infrecuente en la zona. Sin embargo, es recomendable tenerlo presente para hacer un diagnóstico precoz y tratamiento oportuno.

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“…First, this study was conducted with a relatively small sample size of 25 cases. Penile cancer is a relatively rare disease, occurring in 1.8 per 100,000 [21]. Thus, it would be difficult to investigate a large cohort.…”

Section: Discussionmentioning

confidence: 99%

A low psoas muscle volume is associated with a poor prognosis in penile cancer

et al. 2020

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Background: Sarcopenia was initially recognized as a marker representing the nutritional condition or aging. Recently, sarcopenia has been associated with a poor prognosis and postoperative complications. We examined the importance of sarcopenia as a predictive marker of the prognosis in penile cancer. Materials and Methods: A total of 25 patients diagnosed with penile cancer who underwent penile resection from 2000 to 2010 were analyzed in this study. The psoas muscle index (PMI) was calculated based on psoas area using preoperative axial computed tomography images at the right L3 level divided by the square of the body height. Results: Nineteen (76.0%) patients underwent partial penectomy, and 6 (24.0%) underwent total penectomy. The median (mean ± standard deviation) age was 69.3 (69.0 ± 10.1) years old. Regarding the site of penile cancer, 17 (76.0%) cases were in the glans, 6 (24.0%) were in the foreskin, and 2 (8.0%) were in the shaft. Lymph node metastasis were seen in 6 cases (24.0%), and distant metastasis was seen in 1 case (4.0%). The lower PMI group (< 320.0) showed a significantly poorer progression-free survival than the higher PMI group (≥ 320.0) (p = 0.030), although no significant difference in the overall survival was noted (p = 0.076). Conclusions: Sarcopenia might be a useful prognostic factor in penile cancer patients.

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Penile cancer – Incidence, mortality, and survival in Saxony, Germany

Cited by 20 publications

References 26 publications

Conditional survival after surgery for patients with penile cancer

Conditional survival after surgery for patients with penile cancer

¿Podría ser la diabetes factor de riesgo para cáncer de pene?: a propósito de un caso

A low psoas muscle volume is associated with a poor prognosis in penile cancer

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