Penile Angiokeratomas (PEAKERs) Revisited: A Comprehensive Review

Abstract

Angiokeratomas are benign vascular lesions. Genital angiokeratomas, also referred to as Fordyce angiokeratomas, usually occur on the scrotum in men and the vulva in women. Penile angiokeratoma (PEAKER) is a subtype of genital angiokeratoma in men; clitoral angiokeratoma (CLANKER) is its embryologic analog in women. The PubMed database was used to search the following words: angiokeratoma, clitoris, genital, peaker, penile, penis, rejuvenation, scrotal, scrotum and vulva. The relevant papers and references cited in those papers that were generated by the search were reviewed. The purpose of this article is to summarize the features of PEAKERs. PEAKERs have been described in 54 men. They usually appeared in younger men and had been present for a mean duration of 4 years prior to the individual seeking medical attention. Only 39% of the men had angiokeratoma-associated symptoms:

Penile Angiokeratomas (PEAKERs): An Exceedingly Rare Clinical Variant

“…Penile angiokeratomas (PEAKERs) are an uncommon subtype of genital angiokeratomas [2]. These benign vascular tumors typically presenting as multiple lesions on the corona glans penis.…”

“…Treatment includes cryotherapy and lasers, among others. Dermoscopy should be included as a part of the clinical inspection to avoid unnecessary invasive investigation [2].…”

Intralesional injection of triamcinolone acetonide is an effective treatment for angiokeratoma of the scrotum: a case report

“…It is a type of genital angiokeratoma. The incidence of genital angiokeratoma has been studied in several studies, but its exact prevalence remains unclear [7]. Prolong…”

“…Treatments (Ref.) Advantages DisadvantagesCryotherapy with liquid nitrogen[7] Effective, convenient operation, suitable for several lesions Longer recovery time, not suitable for diffuse lesions…”

A case of penile angiokeratoma, a rare subtype of genital angiokeratoma in a middle-aged male

“…[ 2 ] The term PEAKER was introduced by Basu and Cohen and includes lesions over the glans penis, penile shaft, and foreskin. [ 1 3 ] However, angiokeratoma lesions over the bathing trunk region including the penis in Fabry disease are not included under the ambit of the term. [ 3 ]…”