Penicillin stability in prefilled syringes for the purpose of skin testing for drug allergy

Prefilled syringes for immunoglobulin G (IgG) replacement therapy: clinical experience from other disease settings

“…Amoxicillin, benzylpenicillin, and flucloxacillin all showed stability at 2-7 days. This time is substantially longer than the current shelf-life of 24 hours and supports a change of clinical practice where these agents can be prepared in advance by pharmacies, improving safety and workflow [20]. Good drug stability in prefilled syringes has also been reported for U-500 regular insulin (≥ 28 days when refrigerated) [23], epoetin alfa (up to 6 weeks when refrigerated) [24], netilmicin (300 days at room temperature) [26], fluconazole (77 days at room temperature) [19], and bevacizumab (6 months when refrigerated) [22].…”

“…The stability of medications when provided in prefilled syringes is also important. A variety of different drugs/agents have been evaluated, including epinephrine [21], insulin [23], penicillin [20], epoetin alfa [24], netilmicin [26], fluconazole [19], bevacizumab [22,25], and hepatitis E vaccine [27]. While the clinical indications, conditions of use, and treatment periods differ for these agents, the consensus of these studies was of good drug stability in the prefilled syringe format (Table 2), and confirmed relative to traditional vials in some cases [19,22,24,25].…”