Penicillin-Resistant Gonococci

Seth, Aparna; Johnston, Neil

doi:10.1016/s0140-6736(80)91852-8

Cited by 7 publications

(4 citation statements)

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“…There was no penicillinase-producing strain. Gradual increase of penicillin resistance in non-PPNG strains after 1976 or during the 1970s has been reported from various countries including the U.K. (Nayyar, Michel and Stolz, 1980;Shtibel, 1980;Seth and Johnston, 1980). In the present study, a fall in the percentage of resistant strains was noted in 1980.…”

Section: Discussionsupporting

confidence: 63%

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Penicillin sensitivities of gonoccocci, in 1977-80 from a peripheral health district, and their clinical correlation

Rahman

1982

Postgraduate Medical Journal

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Penicillin sensitivities of gonococci isolated from a peripheral health district were observed during 1977-80 by determining the minimum inhibitory concentrations (MIC) of penicillin. During the same period, outcome of penicillin treatment in patients with gonorrhoea was also observed and recorded. Penicillin resistance, as defined, was found in 19·3% strains in these years, but there were year-to-year variations. None of the strains was a penicillinase producer. Association of higher MICs of penicillin with therapeutic failures was not observed in this study until the MICs were greater than 1·0 mg/l. The findings are discussed together with reviews from other published works.

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Section: Discussionsupporting

confidence: 63%

“…Since then, there have been many such reports. High level of penicillin resistance in non-penicillinase producing strains (non-PPNG) has also been reported recently (Seth and Johnston, 1980), although their clinical correlation was not clearly demonstrated. Most of these reports came from big cities or areas close to them.…”

Section: Introductionmentioning

confidence: 92%

Penicillin sensitivities of gonoccocci, in 1977-80 from a peripheral health district, and their clinical correlation

Rahman

1982

Postgraduate Medical Journal

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“…'6 Widespread use of suboptimal doses of antibiotics for treating gonococcal infection has led to selection of resistant chromosomal mutants in developing countries throughout the world. '8 19 Thus penicillin has to be used either in higher doses20 or with a second drug. '8 The recent outbreak in the USA caused by a non-PPNG strain of N gonorrhoeae that is highly resistant to penicillin21 raises the possibility that such organisms may be widely distributed, but unrecognised, even in developed countries.…”

Section: Appropriate Treatmentmentioning

confidence: 99%

Control of sexually transmitted diseases: view from the United States of America.

Cates¹,

Parra²,

Brown³

1984

Sexually Transmitted Infections

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SUMMARY Past sexually transmitted disease (STD) control efforts in the United States of America have generally permitted a timely response to changes in intervention technology, antibiotic resistance, public funding, and media interest.' 2 Today, however, the expansion of STD organisms and syndromes at logarithmic rates has taxed our traditional labour intensive control approaches. We describe briefly the history of STD control strategies in the United States, discuss the seven components upon which current efforts are based, and speculate about our future programme initiatives.History National programmes to control STD were established in the USA during the early days of the first world war.' For the next half century the focus was almost exclusively on the control of syphilis and its complications. Federal grants to support STD control initiatives were begun in 1939. Rapid treatment centres for syphilis and gonorrhoea were the second world war responses to a perceived STD problem. Widespread availability of penicillin led to a dismantling of the rapid treatment centres and a dissolution of the clinical specialty of venereology, which had largely been syphilology. During the 1950s and 1960s, however, federal assistance continued to support the tracing of sexual partners, serological screening, and patient education services. The STD "epidemiologist" emerged as a central figure in syphilis control efforts.By the late 1960s officials had become concerned with the rapidly escalating number of cases of gonorrhoea. Selective culture media stimulated the development of a national gonorrhoea control strategy.2 Pilot projects were undertaken in six American cities to identify infected women and also to treat the sexual partners of infected men. These projects showed the feasibility of such an approach. In 1972 the federal government dramatically increased its financial assistance to STD control. At the expense of syphilis, gonorrhoea gradually received a larger portion of the federal STD grant during the re-

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“…In 1976, strains of Neisseria gonorrhoeae able to synthesize ß-lactamase, codified by plasmids, were described for the first time more or less simultaneously in the United Kingdom and in the USA (Philips 1976, Ashford et al 1980, Seth & Johnston 1980, Jaffe et al 1981.…”

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confidence: 99%