Penicillin Hypersensitivity — Is Milk a Significant Hazard?: A Review

Dewdney, Janet M.; Edwards, Richard

doi:10.1177/014107688407701013

Cited by 46 publications

(19 citation statements)

References 27 publications

(24 reference statements)

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“…Allergic reactions to antibiotics are well recognized and hypersensitivity to β-lactam compounds is especially prevalent. The literature regarding allergic responses of humans after exposure to drug residues found in milk is sparse and focused primarily on risks associated with exposure to β-lactams (Dewdney and Edwards, 1984;Ormerod, et al, 1987;Wicher et al, 1969). Nepal being one of the member countries of World Trade Organization (WTO) and OIE has obligation to follow standards and rules regarding to Maximum Residue Limit (MRL).…”

Section: Research Articlementioning

confidence: 99%

Assessment of Antibiotic Residues in the Marketed Meat of Kailali and Kavre of Nepal

Raut

Mandal²,

Kaphle

et al. 2017

Int J Appl Sci Biotechnol

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This is a cross-sectional study to detect presence of antibiotic residues in meat sample of Kailali and Kavre districts. Each sample out of 55 meat samples (muscles and liver) of poultry-41, goat-12, buffalo-9 and pig-4 from Kailali and Kavre was tested for different groups of antibiotic residues separately. The antibiotics tested were Penicillin, Tetracycline, Aminoglycosides, Macrolides and Sulfonamides. Samples were preserved at -84˚C in the deep freezer after collecting in sterile plastic pouch. Rapid test kit (78.9% sensitivity and 96.7% specificity) of G9 Co. Ltd., Thailand was used to detect residues in the samples. The protocol of kit was followed for the test. The overall prevalence of antibiotic residues in meat was around 22%. Meat samples exceeding the Maximum Residue Limit (MRL) were 6. Liver was found with higher number of residues than muscles. The organ and location wise prevalence of residue was found statistically significant at p<0.05. The samples contained alarmingly high level of antibiotic residues which is because of neglecting the withdrawal period. The prescription of antibiotic is not prudent.

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Section: Research Articlementioning

confidence: 99%

Assessment of Antibiotic Residues in the Marketed Meat of Kailali and Kavre of Nepal

Raut

Mandal²,

Kaphle

et al. 2017

Int J Appl Sci Biotechnol

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“…A few cases of minor allergic reactions (e.g., skin rashes) in individuals previously sensitized to penicillin G residues in milk and meat have been documented, as well as strong evidence linking a widespread agricultural use of antibiotics to an increase in antibiotic resistance among the animal and human pathogens (Dewdney et al 1984;Franco et al 1990;H u b e r 1971;Kindred et al 1993;Mitchell et al 1995;Ormerod et al 1987).…”

Section: Penicillin Elisa Plasma Cattle Contamination Live Animal mentioning

confidence: 99%

Adiaspores of Emmonsia parva var. crescens in Lungs of Small Rodents in a Rural Area

Fischer¹

2001

Acta Vet. Brno

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The purpose of this study was to compare the occurrence of Emmonsia parva var. crescens in populated and unpopulated habitats of a rural area (in a village with 615 inhabitants and in surrounding forests without human population) as indicated by findings of adiaspores in lungs of small rodents captured in these habitats. Adiaspores of E. parva var. crescens were found in lungs of 13 (9.6 %) out of 135 examined rodents. Four rodent species out of 7 were infected: the bank vole (Clethrionomys glareolus, 15.6 %), the house mouse (Mus musculus, 5.6 %), the wood mouse (Apodemus sylvaticus, 3.2 %) and the yellow-necked field mouse (A. flavicollis, 16.7 %). The highest prevalence was found in the A. flavicollis and in the C. glareolus in the village and in the forests, respectively. Intensity of the infection was low or moderate (below 100 adiaspores per animal). The highest prevalence of the infection was found in spring. The prevalence was not influenced by sex of the animals. Occurrence of both saprophytic stage of E. parva var. crescens and rodents can be enabled by plant cover of uncultivated soil in the village, where the same plant species as in the surrounding forests occur. Therefore the risk of infection for humans and animals is not limited only to forest (unpopulated) habitats. Sapronoses, emmonsiosis, Arvicolidae, Muridae, Czech RepublicEmmonsiosis (adiaspiromycosis) is a world-wide distributed, largely neglected and underdiagnosed pulmonary disease of mammals, including humans (H u b álek et al. 1998). Only one causative agent of emmonsiosis, the fungus Emmonsia parva var. crescens (Emmons et Jellison 1960, occurs in the Czech Republic (Dvofiák et al. 1973). The infection is widespread especially among rodents of the families Arvicolidae and Muridae (H u b álek et al. 1991) and more rarely in the families Sciuridae (Kfiivanec et al. 1976) and Cricetidae (H u b álek 1999). The source of infection is the saprophytic stage of fungus producing minute conidia. After inhalation of the conidia by mammalian host, large thick-walled spherules called adiaspores develop in host tissues, most often in lungs. Expanding adiaspore, a parasitic stage of the fungus, causes inflammatory reaction in lung tissue (Koìousek et al. 1971;Halouzka et al. 1989;Ooi and Lin 1996), which leads to collapse of the adjacent alveoli resulting, in case of massive infection, to respiratory distress or even lung failure (H u bálek 1999). Macroscopic pathomorphological changes are densely disseminated whitish nodules about 1 to 2 mm in diameter, described by Koìousek et al. (1971) in a case human emmonsiosis. After death of the infected host, the saprophytic stage can grow from the adiaspores released from dead host's body (Kfiivanec and Otãená‰ek 1977). Although the main source of conidia is the soil (Dvofiák et al. 1973; Prokopiã and ·tûrba 1978), conditions of natural infection were not studied sufficiently. Because of danger for humans (Koìousek et al. 1971; England and Hochholzer 1993;Nuorva et al. 1997;de Montpréville et al. 1999) a...

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“…This can be achieved by chemical synthesis, but penicillins react spontaneously, if slowly, with proteins under physiological conditions and can then elicit penicillin specific allergic responses. However, attempts to calculate the amount of penicillin in a low exposure situation able to sensitize an individual should be viewed with caution, as discussed by Dewdney and Edwards [11] in the case of allergy caused by penicillin in milk. During the sensitization phase the immune system responds to the allergen but the subject does not experience any symptoms.…”

Section: Introductionmentioning

confidence: 99%

Anaphylaxis to penicillins after non-therapeutic exposure: an immunological investigation

Blanca¹,

Garcia²,

Vega³

et al. 1996

Clin Exp Allergy

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Penicillin Hypersensitivity — Is Milk a Significant Hazard?: A Review

Cited by 46 publications

References 27 publications

Assessment of Antibiotic Residues in the Marketed Meat of Kailali and Kavre of Nepal

Assessment of Antibiotic Residues in the Marketed Meat of Kailali and Kavre of Nepal

Adiaspores of Emmonsia parva var. crescens in Lungs of Small Rodents in a Rural Area

Anaphylaxis to penicillins after non-therapeutic exposure: an immunological investigation

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