Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?

Poghossian, Arshak; Yoshinobu, Tatsuo; Simonis, Anette; Ecken, Holger; Lüth, H.; Schöning, Michael J.

doi:10.1016/s0925-4005(01)00819-x

Cited by 95 publications

(48 citation statements)

References 17 publications

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“…As the EnFET works on the principle of pH change caused by an enzymatic reaction, the sensitivity, detection limit and linear range of the calibration curve of EnFETs are mostly affected by pH, buffer solution and ion concentration of the buffer solution. Higher penicillin sensitivity (about 120 mV mM 21 ) and an extremely low detection limit (5 mM) of an EnFET described in [109][110][111][112] was achieved by using an optimised low capacity polymix buffer solution.…”

Section: Enfetmentioning

confidence: 99%

Recent advances in biologically sensitive field-effect transistors (BioFETs)

Schöning

Poghossian

2002

Analyst

541

339

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Section: Enfetmentioning

confidence: 99%

Recent advances in biologically sensitive field-effect transistors (BioFETs)

Schöning

Poghossian

2002

Analyst

541

339

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“…Ion-sensitive field-effect transistors (ISFETs) and relatives (EnFETs, BioFETs, etc.) are the canonical examples [6], but similar mechanisms operate in semiconducting nanowires [7], semiconducting carbon nanotubes [8], electrolyte-insulator-semiconductor structures [9][10][11][12], suspended gate thin film transistors [13], and light-addressable potentiometric sensors [14,15]. These field-effect sensors rely on the interaction of external charges with carriers in a nearby semiconductor and thus exhibit enhanced sensitivity at low ionic strength where counterion shielding is reduced; this is explained in a recent review [16] and evidenced by the low salt concentrations often used (e.g., [7,10]).…”

Section: Introductionmentioning

confidence: 99%

Label‐Free Impedance Biosensors: Opportunities and Challenges

2007

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Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and other applications due to low cost, ease of miniaturization, and label-free operation. Unlabeled DNA and protein targets can be detected by monitoring changes in surface impedance when a target molecule binds to an immobilized probe. The affinity capture step leads to challenges shared by all label-free affinity biosensors; these challenges are discussed along with others unique to impedance readout. Various possible mechanisms for impedance change upon target binding are discussed. We critically summarize accomplishments of past label-free impedance biosensors and identify areas for future research.

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“…Such FET devices are reviewed in greater detail in Section 2.1.4. A further example and novel optical/electrochemical hybrid technique is known as a Light Addressable Potentiometric Sensor (LAPS) [32,33,34,35,36]. LAPS is a silicon-based detector that takes advantage of the photovoltaic effect to selectively determine the point of measurement.…”

Section: −11mentioning

confidence: 99%

Electrochemical Biosensors - Sensor Principles and Architectures

Grieshaber

MacKenzie

Vörös

et al. 2008

Sensors

839

636

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Quantification of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. However, converting the biological information to an easily processed electronic signal is challenging due to the complexity of connecting an electronic device directly to a biological environment. Electrochemical biosensors provide an attractive means to analyze the content of a biological sample due to the direct conversion of a biological event to an electronic signal. Over the past decades several sensing concepts and related devices have been developed. In this review, the most common traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, such as nanowire or magnetic nanoparticle-based biosensing. Additional measurement techniques, which have been shown useful in combination with electrochemical detection, are also summarized, such as the electrochemical versions of surface plasmon resonance, optical waveguide lightmode spectroscopy, ellipsometry, quartz crystal microbalance, and scanning probe microscopy. The signal transduction and the general performance of electrochemical sensors are often determined by the surface architectures that connect the sensing element to the biological sample at the nanometer scale. The most common surface modification techniques, the various electrochemical transduction mechanisms, and the choice of the recognition receptor molecules all influence the ultimate sensitivity of the sensor. New nanotechnology-based approaches, such as the use of engineered ion-channels in lipid bilayers, the encapsulation of enzymes into vesicles, polymersomes, or polyelectrolyte capsules provide additional possibilities for signal amplification. In particular, this review highlights the importance of the precise control over the delicate interplay between surface nano-architectures, surface functionalization and the chosen sensor transducer principle, as well as the usefulness of complementary characterization tools to interpret and to optimize the sensor response.

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Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?

Cited by 95 publications

References 17 publications

Recent advances in biologically sensitive field-effect transistors (BioFETs)

Recent advances in biologically sensitive field-effect transistors (BioFETs)

Label‐Free Impedance Biosensors: Opportunities and Challenges

Electrochemical Biosensors - Sensor Principles and Architectures

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