Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer

Siqueira, José R.; Abouzar, Maryam H.; Poghossian, Arshak; Zucolotto, Valtencir; Oliveira, Osvaldo N.; Schöning, Michael J.

doi:10.1016/j.bios.2009.07.007

Cited by 92 publications

(76 citation statements)

References 29 publications

(31 reference statements)

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“…110,111 For both modified EIS and LAPS devices, the film containing nanotubes enhanced the sensor performance, with higher sensitivity, more stable signal, low drift, and fast response time. The influence of this PAMAM/ SWNT−penicillinase film on FED device performance pointed to the importance of film morphology for signal response.…”

Section: Nanomaterials For Clinical Diagnosismentioning

confidence: 99%

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

Oliveira

Iost

Siqueira

et al. 2014

ACS Appl. Mater. Interfaces

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153

137

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Clinical diagnosis has always been dependent on the efficient immobilization of biomolecules in solid matrices with preserved activity, but significant developments have taken place in recent years with the increasing control of molecular architecture in organized films. Of particular importance is the synergy achieved with distinct materials such as nanoparticles, antibodies, enzymes, and other nanostructures, forming structures organized on the nanoscale. In this review, emphasis will be placed on nanomaterials for biosensing based on molecular recognition, where the recognition element may be an enzyme, DNA, RNA, catalytic antibody, aptamer, and labeled biomolecule. All of these elements may be assembled in nanostructured films, whose layer-by-layer nature is essential for combining different properties in the same device. Sensing can be done with a number of optical, electrical, and electrochemical methods, which may also rely on nanostructures for enhanced performance, as is the case of reporting nanoparticles in bioelectronics devices. The successful design of such devices requires investigation of interface properties of functionalized surfaces, for which a variety of experimental and theoretical methods have been used. Because diagnosis involves the acquisition of large amounts of data, statistical and computational methods are now in widespread use, and one may envisage an integrated expert system where information from different sources may be mined to generate the diagnostics.

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Section: Nanomaterials For Clinical Diagnosismentioning

confidence: 99%

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

Oliveira

Iost

Siqueira

et al. 2014

ACS Appl. Mater. Interfaces

Self Cite

153

137

View full text Add to dashboard Cite

show abstract

“…Several kinds of sensing elements and detection methods have been studied for e-noses and mainly e-tongues [45,51,[57][58][59][60][61][62], which allow applicability in fields as food [57,[62][63][64][65][66], wines [67], water [68] and pharmaceutical analysis [66]. The importance of the e-tongues and e-noses to biosensing stems from the possible extension through the incorporation of sensing units capable of molecular recognition [69][70][71][72].…”

Section: Electronic Tongues and Nosesmentioning

confidence: 99%

Information Visualization to Enhance Sensitivity and Selectivity in Biosensing

Oliveira¹,

Pavinatto²,

Constantino³

et al. 2012

Biointerphases

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An overview is provided of the various methods for analyzing biosensing data, with emphasis on information visualization approaches such as multidimensional projection techniques. Emphasis is placed on the importance of data analysis methods, with a description of traditional techniques, including the advantages and limitations of linear and non-linear methods to generate layouts that emphasize similarity/dissimilarity relationships among data instances. Particularly important are recent methods that allow processing high-dimensional data, thus taking full advantage of the capabilities of modern equipment. In this area, now referred to as e-science, the choice of appropriate data analysis methods is crucial to enhance the sensitivity and selectivity of sensors and biosensors. Two types of systems deserving attention in this context are electronic noses and electronic tongues, which are made of sensor arrays whose electrical or electrochemical responses are combined to provide “finger print” information for aromas and tastes. Examples will also be given of unprecedented detection of tropical diseases, made possible with the use of multidimensional projection techniques. Furthermore, ways of using these techniques along with other information visualization methods to optimize biosensors will be discussed.

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“…measurable signal. [13][14][15] Various analytes of environmental, medical, biological, pharmaceutical, or industrial interest can be monitored using an electrochemical biosensor, which provides a measure of the analyte concentration by detecting the current generated in the oxidation or reduction of the redox species. 16 In electrochemical biosensors, the biological material is directly immobilized on a electrode by adsorption, covalent bonding, or encapsulation within a coating layer of a permeable conductive polymer or cross-linked reagent.…”

Section: Introductionmentioning

confidence: 99%

Disposable Biosensors for Clinical Diagnosis

Janegitz¹,

Cancino²,

Zucolotto³

2014

j. nanosci. nanotech.

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We present an overview on the use of disposable electrochemical biosensors for diagnostics, focusing on the applications of these devices as immunosensors and DNA sensors in the point-of-care diagnostics. Analytical biosensors have emerged as efficient alternatives for the detection of innumerous diseases, because of their high specificity and the convenience of detecting the electrochemical signals produced by the presence of an analyte using a portable equipment. This review highlights the recently developed strategies toward immobilization of different biological molecules on disposable electrodes such as carbon nanotubes and metal nanoparticles. In the course of the review, we first introduced the disposable biosensors, followed by an overview of the immunosensors, and discussed the applications of DNA sensors and disposable biosensors in point-of-care diagnostics. We also have evaluated the prospects and future applications of these devices in the field of biomedical research.

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Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer

Cited by 92 publications

References 29 publications

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

Information Visualization to Enhance Sensitivity and Selectivity in Biosensing

Disposable Biosensors for Clinical Diagnosis

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