“…Redness, thickening, ptosis and fissures of the lids have been described. 22 Few systemic reactions of a severe nature have been encountered.23 These untoward reactions have been urticaria, fever, transient azotemia, thrombophlebitis, chills, faintness and muscular cramps, but most of these reactions were thought to be due to the impurities in the preparation rather than to the penicillin itself.…”