Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp.

Orfali, Raha; Perveen, Shagufta; Peng, Jiangnan; Alqahtani, Ali S.; Nasr, Fahd A.; Ahmed, Mohammad Z.; Luciano, Paolo; Chianese, Giuseppina; Al‐Taweel, Areej Mohammad; Taglialatela‐Scafati, Orazio

doi:10.1016/j.fitote.2022.105330

Cited by 1 publication

(3 citation statements)

References 16 publications

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“…RO-11, which was collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia. Preaustinoid C showed significant activity against lipopolysaccharide (LPS)-induced NO production and a selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells [27]. The mutant filamentous fungus Aspergillus nidulans has been found to produce protoaustinoid A (15) [17].…”

Section: Tetracyclic Systems-rings a And B Are Bicyclic Fusedmentioning

confidence: 99%

“…Furthermore, two new meroterpenoids, namely, 1-methoxy-hydropreaustinoid A1 (26) and hydroberkeleyone B (27), have been isolated through the aid of Liquid Chromatograph Mass Spectrometer (LC-MS) from the sponge-derived fungus Eupenicillium sp. 6A-9, and both of them have immune-suppressive activities with IC 50 values of 42.3 and 28.5 µM, respectively [30].…”

Section: Tetracyclic Systems-rings a And B Are Bicyclic Fusedmentioning

confidence: 99%

“…[2]. Brasilianoid J (86) was isolated from the marine-derived fungus P. brasilianum WZXY-m122-9 [27] (Figure 9). Penicianstinoids A-B (87-88) were obtained from the mangrovederived fungus Penicillium sp.…”

Section: Hexacyclic Systems-rings a And B Are Spirocyclicmentioning

confidence: 99%

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Austin-Type Meroterpenoids from Fungi Reported in the Last Five Decades: A Review

He,

Chen,

Liu

et al. 2024

JoF

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Austin was first isolated as a novel polyisoprenoid mycotoxin from Aspergillus ustus in 1976. Subsequently, some new austin-type meroterpenoids (ATMTs) have been continually found. This review attempts to give a comprehensive summary of progress on the isolation, chemical structural features, biological activities, and fungal biodiversity of 104 novel ATMTs from 5 genera of terrestrial- and marine-derived fungi reported from October 1976 to January 2023. The genera of Penicillium and Aspergillus are the two dominant producers, producing 63.5% and 30.8% of ATMTs, respectively. Moreover, about 26.9% of ATMTs display various pronounced bioactivities, including insecticidal, anti-inflammatory, cytotoxicity, antibacterial, and PTP1B inhibitory activities. The chemical diversity and potential activities of these novel fungal ATMTs are reviewed for a better understanding, and a relevant summary focusing on the source fungi and their taxonomy is provided to shed light on the future development and research of austin-type meroterpenoids.

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Section: Tetracyclic Systems-rings a And B Are Bicyclic Fusedmentioning

confidence: 99%

Section: Tetracyclic Systems-rings a And B Are Bicyclic Fusedmentioning

confidence: 99%