Pengaruh Vitamin D terhadap Indeks Apoptosis pada Penderita Kanker Payudara

Abstract

AbstrakKanker payudara merupakan penyakit yang paling sering pada pada wanita dan menjadi penyebab kematian terbanyak akibat kanker. Penyebab kanker payudara sangat multifaktorial salah satu yang masih menjadi kontroversi adalah karena defisiensi vitamin D. Peran vitamin D dalam tubuh sangat luas selain menjaga homeostasis kalsium dan fosfat, vitamin D juga berperan sebagai anti kanker melalui mekanisme antara lain, menginduksi apoptosis. Peran vitamin D dalam menginduksi apoptosis pada sel kanker menarik perhatian, karena nilai apoptosis pada sel kanker dapat menjadi indikator untuk memprediksi respon sel kanker terhadap terapi. Tingkat apoptosis dinilai dengan indeks apoptosis. Tujuan penelitian ini adalah melihat pengaruh vitamin D terhadap indeks apoptosis pada kanker payudara. Sampel penelitian ini adalah penderita kanker payudara yang baru didiagnosis di Polibedah Onkologi RSUP HAM Medan. Pemeriksaan kadar vitamin D menggunakan metode ELISA dan Indeks apoptosis diperiksa dengan pewarnaan HE menggunakan mikroskop cahaya. Rerata indeks apoptosis pada penderita kanker payudara dengan kadar vitamin D yang sufisiensi lebih tinggi daripada rerata indeks apoptosis pada kadar vitamin D yang insufisiensi dan defisiensi. Simpulan hasil penelitian ini ialah terdapat perbedaan indeks apoptosis yang bermakna antara penderita kanker payudara dengan kadar vitamin yang sufisiensi dan dengan kadar vitamin D yang defisiensi. Rerata apoptosis indeks lebih tinggi pada kadar vitamin D yang sufisiensi. Kata kunci: kanker payudara, Kadar vitamin D, Indeks apoptosis AbstractBreast cancer is the most common type of cancer found in women and the most caused of death due to cancers. The cause of breast cancer was multifactorial, and still become controversial is vitamin D deficiency. So many roles of vitamin D for body, not only preserves homeostasis for calcium and phosphate, but also serves an anti cancer by the mechanism such as inducing an apoptotic. The role of Vitamin D in apoptotic on cancer cells to reduces and attracts an attention, because the value of apoptotic on cancer cells will be an indicators to predicted response for cancer cells therapy. The level of apoptotic be measured by apoptotic index. The objective of this study was to investigated the influence of vitamin D on apoptotic index in breast cancer. The sample of study was sufferers breast cancer that have new diagnosed in poly surgical in RSUP HAM Medan. Examination of Vitamin D levels used by ELISHA method and apoptotic index verify with HE staining that exerted by microscope light. The average of apoptotic index in breast cancer patients with higher vitamin D levels is higher than the average of apoptotic index in vitamin D with deficiency and insufficiency. The conclusion is the significant different between apoptotic index with vitamin D deficiency and vitamin D insufficiency in breast cancer.

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

“…In these patients, it is possible that the AKI occurs because of kidney hypoperfusion and also due to sepsis, as well as dehydration or volume depletion due to lack of intake. Besides, it is possible that this condition also a result of thrombotic microangiopathy from thrombocytosis, which causes intrinsic abnormalities of the kidneys to AKI (intra-renal AKI) 21 . In this patient, we adjusted the protein target based on kidney function.…”

“…AKI (Acute Kidney Injury) is common in cancer patients and have medium and long term consequences because it is related to kidney function21 . Patients with cancer are susceptible to the development of cancer or chemotherapy-related conditions that ultimately result in renal hypoperfusion…”