Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2

Abstract

Background: Malondialdehyde (MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress and MDA production. The purpose of this study was to prove the effects of combined vitamin C and vitamin E on MDA plasma levels in T2DM patients.Methods: This double blind randomized pre post test control group design was carried out on 35 patients with T2DM without complication (age 40-60 yr) in Makassar. The treatment group (n=18) received vitamin C 250 mg/day plus vitamin E 400 IU/day and the control group (n=17) received placebo (seaweed powder 250 mg), for six weeks. Vitamin C was consumed before meal and vitamin E after meal. MDA levels were measured before and after supplementation by using TBARs method. Food intake and activity were derived from 24-hour recall method.Results: There was no different on MDA levels at baseline (p=0.151). At the end of the study, MDA levels increased in control group (5.8±2.74 to 7.2±3.00 nmol/ml; p=0.044) but not in the treatment group (7.2±2.88 to 7.7±2.02 nmol/ml; p=0.490). There was no difference in MDA alteration between the goups (p=0.316). There was no different in MDA levels at the end of the study (p=0.061) and confirmed after controlling the confounding variables: vitamin E intake and fasting blood glucose (p=0.809). Conclusion: Combined vitamin C 250 mg and vitamin E 400 IU for 6 weeks did not reduce MDA levels, but inhibit MDA production in T2DM patients.

The Correlation of Hba1c Level With GSH-PX Enzyme Activity, AOPP, and MDA Levels in The Eye Lenses of Diabetic Cataract Patients

“…24 However, Yasin et al, stated in his journal that the combination of 250 mg vitamin C and vitamin E 400 IU for six weeks could only inhibit the increase in the patient's plasma MDA level. 25 Restriction of diet consumption factors that contain antioxidants is challenging to perform; therefore, it might affect the AOPP level in the lens of the patients. Several experimental studies show that administering compounds containing antioxidants in Wistar rats such as diosmin, naringenin, resveratrol 26 , rosmarinic acid, sinapic acid 27 , and caffeine 28 can reduce AOPP levels in the lens.…”

Kombinasi Konsumsi Air Alkali dan Akupresur terhadap Nilai Ankle Brachial Index Penderita Diabetes Melitus Tipe II

“…Selanjutnya, stres oksidatif akan meningkatkan peroksidasi lipid yang akan menghasilkan malondialdehid (MDA). Konsentrasi MDA yang meningkat pada penderita diabetes mellitus, menyebabkan kerusakan sel endotel pembuluh darah, rusaknya sel endotel akan menyebabkan terjadinya proinflamasi dan proatherogenik pembuluh darah sehingga menyebabkan terjadi aterosklerotik (Yasin et al, 2015). Aterosklerotik menyebabkan penurunan aliran darah (perfusi) ke ekstremitas bawah yang ditandai dengan penurunan Ankle Brachial Index (ABI) (Siswantoro et al, 2018;Soviana et al, 2014).…”

Novel Therapeutic Potential of 'Ambon' Banana and Green Bean Sprout Extracts in Mitigating Cigarette Smoke-Induced Testicular Oxidative Stress and Sperm Quality Impairment

“…GSSG is then converted to GSH again by the influence of the glutathione reductase enzyme. Based on the antioxidant action, consuming antioxidants will be better if given not in single form, but in combination (Yasin et al, 2015)…”