Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) terhadap Epididimis, Prostat  dan Vesikula Seminalis

Carolin, Bunga Tiara; Salni, Salni; Nita, Sri

doi:10.32539/bji.v5i1.7972

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…In addition, the content of flavonoids which can be etrogenic can occupy estrogen receptors in the body and cause an estrogen-like effect, causing inhibition of LH and FSH secretion. As a result of disrupted LH secretion, it causes the growth and number of Leydig cells to decrease so that the production of the hormone testosterone decreases (Carolin et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Mahayani

Rusmiatik

2022

ijhs

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The development of contraceptive methods is more focused on female contraception than men is still lacking. Papaya leaves are thought to have an antifertility effect due to the content of secondary metabolites, namely flavonoids, alkaloids, saponins, tannins and papain enzymes that have estrogenic effects that can disrupt hormone regulation in the hypothalamic-pituitary-gonadal axis. This study aimed to prove the administration of ethanol extract of papaya leaves (Carica papaya L.) on the histopathological features of the testicles of young adult mice (Mus musculus). Subjects and Method: This research uses an experimental study with a post-test only control group design. The samples used were male Swiss Webster strain mice (Mus musculus) 2-3 months old with a bodyweight of 20-30 grams as many as 36 individuals were divided into 2 groups. The control group (P0) was given 0.5 ml of Tween 3% and the treatment group (P1) was given ethanol extract of Papaya Leaf (Carica papaya L.) 0.21 mg/gram BW as much as 0.5 ml for 36 days orally. The data obtained were analyzed using the Independent Sample T-test. Result: A total of 11 articles from Asia continent (India, Bangladesh, Philipina, and Nepal).

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Section: Discussionmentioning

confidence: 99%

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Mahayani

Rusmiatik

2022

ijhs

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“…Peningkatan jumlah penduduk yang sangat tinggi merupakan masalah yang serius bagi negara Indonesia. Terutama dalam kondisi perekonomian negara yang mulai terpuruk (Carolin et al, 2019). Kenaikan yang tinggi dalam jumlah penduduk ini, berkaitan dengan terjadinya peningkatan angka pengangguran, tingginya angka kemiskinan serta bertambahnya angka kriminalitas.…”

Section: Pendahuluanunclassified

“…Kenaikan yang tinggi dalam jumlah penduduk ini, berkaitan dengan terjadinya peningkatan angka pengangguran, tingginya angka kemiskinan serta bertambahnya angka kriminalitas. Salah satu upaya untuk menanggulangi masalah pertumbuhan penduduk yang sangat tinggi serta penurunan angka kematian ibu karena kehamilan adalah dengan menggunakan alat kontrasepsi (Carolin et al, 2019).…”

Section: Pendahuluanunclassified

Estrogenic Effects of Tapak Dara (Catharantus roseus) Leaf Methanol Extract on The Estrus Cycle of Adult Female Mice (Mus musculus) Balb/C Strain

Fatmala

Mahrus

Zulkifli

2022

JBT

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Tapak dara plant is a plant that contains several active compounds, such as phenolic acids, flavonoids and alkaloids. The tapak dara plant can act as a sedative, urinary laxative, stop bleeding, and neutralize toxins. In addition, tapak dara leaf extract contains ingredients that can act as antifertilization. This study aimed to determine the effect of methanol extract of tapak dara leaf on the estrus cycle of adult female mice (Mus musculus) Balb/C strain. This research is an experimental research by testing cause and effect. The hypothesis test used in this study was one-way ANOVA and BNT test. The significance value of giving tapak dara leaf methanol extract to female mice showed a significant value so that it can be said that the administration of tapak dara leaf methanol extract caused the estrus cycle of female mice to be longer. The significance value of estrogenic activity in mice shows a significant value of 0.047, so it can be said that estrogen activity also affects the length of the estrus cycle. The results of hypothesis testing using the one-way ANOVA test were significant, so it can be concluded that the methanol extract of tapak dara leaves can cause the estrus cycle of female mice to be longer.

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“…An increase in population results in unemployment, poverty rates and increased criminal cases (Carolin et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The World Health Organization (WHO) developed male contraceptives from herbs because they have advantages such as low cost, safety, easy to obtain, low toxicity, and minimal side effects (Carolin et al, 2019). Many attempts have been made to develop contraception methods for men by utilizing herbal plants which are predicted to have antifertility (Fatmawati et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

Mahayani¹,

Satriyasa²,

Widianti³

2022

kedokteran

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Increasing population is one of the problems faced in Indonesia. Men's participation and knowledge of contraception is still lacking. Papaya leaves are thought to have an antifertility effect due to the content of secondary metabolites, namely flavonoids, alkaloids, saponins, tannins and papain enzymes that have estrogenic effects that can interfere with hormone regulation in the hypothalamic-pituitary-gonadal axis. This study used an experimental study with a post-test only control group design. The samples used were Swiss Webster strain male mice (Mus musculus) aged 2-3 months with a body weight of 20-30 grams as many as 36 mice divided into 2 groups. The control group (P0) was given 0.5 ml of 3% Tween and the treatment group (P1) was given 0.21 mg/gram BW ethanol extract of papaya leaves (Carica papaya L.) for 36 days orally. The data obtained were analyzed using the Independent Sample T-test. This study showed the results: (1) the average concentration of spermatozoa in the control group (107.6 million/ml) was higher than the treatment group (83.0 million/ml) with p=0.000; (2) the mean of rapidly progressive spermatozoa motility in the control group (41.0 µm/sec) was higher than the treatment group (19.0 µm/sec) with p= 0.000; (3) the average viability of spermatozoa in the control group (87.7%) was higher than the treatment group (71.9%) with p=0.000; (4) the normal morphological mean of the spermatozoa treatment group (81.6%) was higher than the normal morphological mean of the treatment group (38.1%) with p=0.000. Keywords: Male Contraception; Papaya Leaf Extract; Spermatozoa Quality.

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Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) terhadap Epididimis, Prostat dan Vesikula Seminalis

Cited by 4 publications

References 2 publications

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Estrogenic Effects of Tapak Dara (Catharantus roseus) Leaf Methanol Extract on The Estrus Cycle of Adult Female Mice (Mus musculus) Balb/C Strain

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

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