Penetration of the blood–brain barrier and the anti-tumour effect of a novel PLGA-lysoGM1/DOX micelle drug delivery system

Abstract

a) Diagram depicting the preparation of drug delivery system of PLGA-lysoGM1/DOX micelles. b) Schematic illustration of micelles elicited antitumor. c) Micelles cross BBB via micropinocytosis and autophagy/lysosomal pathways.

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

“…TPH/PTX nano-micelles, consist of TPP-Pluronic F127-hyaluronic acid (TPH) and paclitaxel, revealed notable cancer targeting and powerful anticancer effect by entering acidic lysosomes through macropinocytosis in breast cancers ( 178 ). PLGA-lysoGM1/DOX nano-micelles, a new nano-carrier, exhibited efficient cell absorbing through macropinocytosis, autophagy/lysosomal approach, and immense potential to treat neurologic diseases such as glioma ( 179 ). cGQDs, carboxylated graphene quantum dots, entered human cervical cancer cells mainly through the macropinocytosis-dependent pathway and showed outstanding antitumor ability and low systemic toxicity ( 180 ).…”

Potential of Nanocarrier-Based Drug Delivery Systems for Brain Targeting: A Current Review of Literature

“…Nanoformulation has shown excellent anti-glioma outcomes in rats, which shows its potential as an antiglioma medicine. 89 Shiraishi et al carried out the study in which gadolinium-micelles (Gd-micelles) was made as a contrasting agent for MRI. Later intravenous injection into a rat for approximately half an hour, ischemic hemisphere contrasted images have shown the BBB and its distribution area in the ischemic hemisphere.…”

“…Nanoformulation has shown excellent anti-glioma outcomes in rats, which shows its potential as an anti-glioma medicine. 89 …”

Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

“…7,15 Nanoparticles containing brain tumor targeting ligands such as cRGD peptides, 16 antibody to EGFRvIII, 17 transferrin, 18,19 and chlorotoxin (CTX) 20 can be targeted to glioma tumors that originate within the central nervous system. [21][22][23][24] The angiopep family of peptides can also cross the BBB via a low-density lipoprotein receptor-related protein (LRP) mediated pathway. 13,25 Among them, angiopep-2 with a molecular weight of 2.4 kDa promotes receptor-mediated transport through LRP1, resulting in higher in vivo and in vitro transcytosis capacity than other targeting ligands.…”