Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression

Lee, M R; Jayant, Rahul Dev

doi:10.1007/s00441-018-2959-y

Cited by 31 publications

(30 citation statements)

References 68 publications

(61 reference statements)

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“…BBB destabilization has been demonstrated to increase the incidence of stroke and neurodegenerative diseases as vascular dementia. 16,17 Moreover, the breaking of the BBB has been implicated in the transfer of the malaria parasite into the brain. 18 Immunoglobulin G (IgG) extravasation is commonly used as an index of BBB disruption.…”

Section: Introductionmentioning

confidence: 99%

Effects of centrifugation and whole-body vibrations on blood–brain barrier permeability in mice

et al. 2020

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Modifications of gravity levels induce generalized adaptation of mammalian physiology, including vascular, brain, muscle, bone and immunity functions. As a crucial interface between the vascular system and the brain, the blood-brain barrier (BBB) acts as a filter to protect neurons from pathogens and inflammation. Here we compare the effects of several protocols of hypergravity induced by centrifugation and whole-body vibrations (WBV) on BBB integrity. The immunohistochemistry revealed immunoglobulin G (IgG) extravasation from blood to hippocampal parenchyma of mice centrifuged at 2 × g during 1 or 50 days, whereas short exposures to higher hypergravity mimicking the profiles of spaceflight landing and takeoff (short exposures to 5 × g) had no effects. These results suggest prolonged centrifugation (>1 days) at 2 × g induced a BBB leakage. Moreover, WBV were similarly tested. The short exposure to +2 × g vibrations (900 s/day at 90 Hz) repeated for 63 days induced IgG extravasation in hippocampal parenchyma, whereas the progressive increase of vibrations from +0.5 to +2 × g for 63 days was not able to affect the IgG crossing through the BBB. Overall, these results suggest that the BBB permeability is sensitive to prolonged external accelerations. In conclusion, we advise that the protocols of WBV and centrifugation, proposed as countermeasure to spaceflight, should be designed with progressively increasing exposure to reduce potential side effects on the BBB.

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Section: Introductionmentioning

confidence: 99%

Effects of centrifugation and whole-body vibrations on blood–brain barrier permeability in mice

et al. 2020

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“…BMECs are highly specialized structures due to their extensive tight junctions (TJs) between them (6). They play an important role in BBB function by restricting and precisely regulating the exchange of molecules between the peripheral circulatory system and cnS (7). consequently, as a result of the presence of the BBB, numerous drugs with a molecular weight of >400 Da cannot reach the lesions in the brain (8), severely reducing the therapeutic effect of drugs used in the treatment of cnS diseases.…”

Section: Introductionmentioning

confidence: 99%

Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats

Gao¹,

Chen²,

Hu³

et al. 2020

Mol Med Rep

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The restrictive nature of the blood brain barrier (BBB) brings a particular challenge to the treatment of central nervous system (cnS) disorders. The effect of ultra-wide band electromagnetic pulses (uWB-eMPs) on BBB permeability was examined in the present study in order to develop a safe and effective technology that opens the BBB to improve treatment options for cnS diseases. rats were exposed to a single UWB-EMP at various field strengths (50, 200 or 400 kV/m) and the BBB was examined using albumin immunohistochemistry and evans blue staining at different time periods (0.5, 3, 6 and 24 h) after exposure. The expression and distribution of zonula occludens 1 (Zo-1) were evaluated using western blotting to identify a potential mechanism underlying BBB permeability. The results showed that the BBB permeability of rats exposed to uWB-eMP increased immediately following uWM-eMP treatment and peaked between 3 and 6 h after UWB-EMP exposure, returning to pre-exposure levels 24 h later. The data suggested that UWB-EMP at 200 and 400 kV/m could induce BBB opening, while 50 kV/m UWB-EMP could not. The levels of ZO-1 in the cerebral cortex were significantly decreased at 3 and 6 h after exposure; however, no change was observed in the distribution of Zo-1. The present study indicated that UWB-EMP-induced BBB opening was field strength-dependent and reversible. decreased expression of Zo-1 may be involved in the effect of uWB-eMP on BBB permeability.

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“…The increased abuse of prescription opioids, including morphine, oxycodone, fentanyl, and the nonprescription opiate heroin has resulted in a severe public health crisis across large swaths of America [133][134][135]. In 2017, over two-thirds of drug-overdose deaths resulted from opioid abuse [136], and opioid-overdose-attributed deaths have tripled since the turn of the new millennium [137].…”

Section: Opioidsmentioning

confidence: 99%

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

Odegaard

Chand

Wheeler

et al. 2020

IJMS

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Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.

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Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression

Cited by 31 publications

References 68 publications

Effects of centrifugation and whole-body vibrations on blood–brain barrier permeability in mice

Effects of centrifugation and whole-body vibrations on blood–brain barrier permeability in mice

Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

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