Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?

Baroli, Bianca Maria

doi:10.1002/jps.21817

Cited by 299 publications

(243 citation statements)

References 188 publications

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“…Thus, the overall assessment of the results the study of comparative efficiency enhance trasndermal permeability by organosulfur compounds gold nanoparticles under ultrasound treatment shows that the affected by chemical contact dermatitis skin is permeable better than intact. This is contradicting the data Baroli et al [5], which demonstrated the worst permeability of the damaged skin as compared to intact. Perhaps the factor contributing these differences in our study is the additional ultrasound treatment.…”

Section: Comparative Assessment the Permeability Of Drugs Of Gold Nancontrasting

confidence: 59%

“…Most exogenous nanoparticles, whether viruses, bacteria, dust, allergens or substances do not penetrate the human skin, if the skin barrier is not impaired [3,4]. Several anti-cancer and anti-proliferation drugs have been delivered with dendrimers and nanoparticles, including 5-aminolevulinic acid (ALA), 5-fluorouracil (5FU), paclitaxel, podophyllotoxin, and Realgar [5][6][7][8][9][10][11][12][13]. Photodynamic therapy is based on the delivery of photosensitive drugs to skin lesions followed by targeted light exposure.…”

Section: Introductionmentioning

confidence: 99%

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The Technique of Enhancing the Transdermal Penetration for the Gold Nanoparticles and Perspectives of Application

Khayrullin¹,

Terentyuk²,

Savenkova³

et al. 2013

JCT

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Background: In recent years, worldwide attention of researchers focused on the practical implementation of nanoscale materials in biomedical technology. It's proved that intravenous injected gold nanoparticles are accumulated in tumor tissues. However, when gold nanoparticles injected intravenously negative effects in the internal organs of experimental animals are observed. 160 nm diameter particles affect the wall of blood vessels, resulting in vacuolar degeneration of endothelial cells. Particles with a diameter of 50 nm lead to more expressed changes in the internal organs. Injection of the particles diameter of 15 nm causes moderate degeneration of parenchymal cells of internal organs and circulatory disorders. Materials and Methods: In current research, for the first time using the methods of experimental pathology the permeability of intact and damaged skin for nanoscale gold particles in combination with organosulfur compoundsdimethylsulfoxide and tiofansulfoxide were studied. We used 140 male outbred white rats with an average weight 150 -200 grams. All the animals were divided into one control and three experimental groups. Results: Laser microperforation skin with ultrasound treatment can provide good skin permeability, but in contrast to use of agents with organosulfur compounds inflammatory reaction, the destruction of superficial and deep skin tissue structural elements are observed. The comparative efficacy of dimethylsulfoxide and tiofansulfoxide for transdermal permeability of gold nanoparticles was studied. It's proved that in topical application solution of nanoparticles with organosulfur compounds negative effects of the accumulation of nanoparticles in the internal organs, disorders of organ and tissue microcirculation, development in the degenerative changes are not observed. We found that the depth of penetration of damaged skin (contact dermatitis) for the gold nanoparticles in combination with organosulfur compounds, and ultrasound exposure is substantially higher than the penetration of intact skin.

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Section: Comparative Assessment the Permeability Of Drugs Of Gold Nancontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The Technique of Enhancing the Transdermal Penetration for the Gold Nanoparticles and Perspectives of Application

Khayrullin¹,

Terentyuk²,

Savenkova³

et al. 2013

JCT

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“…To see whether such extended half-lives of plasma species could enable some ROS to penetrate through the skin and tissues, we note that there are openings and channels in the skin to allow diffusion of small molecules and other externally applied agents such as plasma species. These include the lipidic intracellular routes (5 -36 nm in diameter) and trans-follicular routes (10 -210 µm in diameter) [125]. The stratum corneum (SC) and viable epidermis (VE) of the skin (see Fig.…”

Section: Plasma Penetrationmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

107

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To cite this version:M G Kong, M Keidar, K Ostrikov. Plasmas meet nanoparticleswhere synergies can advance the frontier of medicine. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (17) AbstractNanoparticles and low-temperature plasmas have been developed, independently and often along different routes, to tackle the same set of challenges in biomedicine. There are intriguing similarities and contrasts in their interactions with cells and living tissues, and these are reflected directly in the characteristics and scope of their intended therapeutic solutions, in particular their chemical reactivity, selectivity against pathogens and cancer cells, safety to healthy cells and tissues, and targeted delivery to diseased tissues. Time has come to ask the inevitable question of possible plasma-nanoparticle synergy and the related benefits to the development of effective, selective, and safe therapies for modern medicine. This perspective article offers a detailed review of the strengths and weakenesses of nanomedicine and plasma medicine as a stand-alone technology, and then provides a critical analysis of some of the major opportunities enabled by synergising the nanotechnology and the plasma technology. It is shown that the plasma-nanoparticle synergy is best captured through the plasma nanotechnology and its benefits for medicine are highly promising.

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“…However the introduction of TiO2 ultrafine particles has raised the question of whether the particles used in TiO2-based cosmetic products have the potential to penetrate through the stratum corneum (SC) into viable skin layers via intercellular channels, hair follicles and sweat glands (Menzel et al, 2004). The intercellular space between the cells composing the SC is approximately 100 nm 3 and may be widened with topical application of various products (Baroli, 2010). Therefore, nano-TiO2 is suspected to pass through it.…”

Section: Introductionmentioning

confidence: 99%

The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO2 in ex vivo pig skin model under indoor light

Peira

Turci

Corazzari

et al. 2014

International Journal of Pharmaceutics

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Several topical products contain nanometric TiO2 (nano-TiO2), which is an useful and safe component that absorbs UV light and does not cross skin barrier. However nano-TiO2 may impregnate the first layer of the skin (stratum corneum, SC) and generate free radicals, even under low UV irradiation. These properties, largely dependent on TiO2 surface chemistry, may modulate the transdermal drug permeation. To investigate how TiO2 surface properties affect drug permeation, Amphotericin in two different media, in the presence of three differently coated samples, was applied on skin and the flux measured. The naked, but not the coated, nano-TiO2 showed enhancer property, with a fourfold increase of the drug flux. Only the positively-charged naked TiO2 strongly adhered to and altered the SC structure. The oxidative potential towards formate anion and linoleic acid was assessed and a molecular mechanism to elucidate increased skin permeability proposed.To enhance the drug permeation, both a surface charge-driven adhesion and an oxidative disorganization of the SC lipids are required. By modulating TiO2 surface charge (coating) and its oxidative potential (crystalline phase), the enhancer effect of nano-TiO2 may be tuned and turned up or down when transdermal penetration of drug has to be favored or impaired.

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Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?

Cited by 299 publications

References 188 publications

The Technique of Enhancing the Transdermal Penetration for the Gold Nanoparticles and Perspectives of Application

The Technique of Enhancing the Transdermal Penetration for the Gold Nanoparticles and Perspectives of Application

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO2 in ex vivo pig skin model under indoor light

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