Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry

Zhang, Hairong; Salo, Daniel; Kim, David M.; Berezin, Mikhail Y.

doi:10.1117/12.2213754

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Our method of measuring penetration depth was based on the quantitative evaluation of the spatial Michelson contrast introduced in our earlier publications. 23,41 In this method, a sample of interest was placed on top of a grid, as shown schematically in Fig. 5, and the contrast was measured (as shown in the previous section and Fig.…”

Section: Resultsmentioning

confidence: 99%

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

et al. 2016

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Measurement of photon penetration in biological tissues is a central theme in optical imaging. A great number of endogenous tissue factors such as absorption, scattering, and anisotropy affect the path of photons in tissue, making it difficult to predict the penetration depth at different wavelengths. Traditional studies evaluating photon penetration at different wavelengths are focused on tissue spectroscopy that does not take into account the heterogeneity within the sample. This is especially critical in shortwave infrared where the individual vibration-based absorption properties of the tissue molecules are affected by nearby tissue components. We have explored the depth penetration in biological tissues from 900 to 1650 nm using Monte–Carlo simulation and a hyperspectral imaging system with Michelson spatial contrast as a metric of light penetration. Chromatic aberration-free hyperspectral images in transmission and reflection geometries were collected with a spectral resolution of 5.27 nm and a total acquisition time of 3 min. Relatively short recording time minimized artifacts from sample drying. Results from both transmission and reflection geometries consistently revealed that the highest spatial contrast in the wavelength range for deep tissue lies within 1300 to 1375 nm; however, in heavily pigmented tissue such as the liver, the range 1550 to 1600 nm is also prominent.

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Section: Resultsmentioning

confidence: 99%

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

et al. 2016

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Cryogenic mid-wave infrared hyperspectral Fabry-Perot filter based on a tensile-strained single-layer subwavelength grating mirror

Mao¹,

Dong

Liu

et al. 2022

Opt. Express

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We report here the first demonstration of a cryogenic mid-wave infrared (MWIR) hyperspectral fixed-cavity Fabry-Perot filter based on a suspended tensile-strained single-layer 2-D subwavelength grating (SWG) mirror. Optical design optimization of the 2-D SWG mirror and parameter tolerance study are performed. For the first time, process control of grating air-hole sidewall angle and the grating air-hole fill-factor fabrication error caused by e-beam lithography electron-scattering effect is reported. At 80 K, namely the operating temperature of MWIR photodetectors, the as-fabricated suspended 2-D SWG mirror has achieved excellent surface flatness with a slight center-to-edge bowing of 15 nm over a 1-mm2 large mirror area and a high average reflectivity of 0.97 across a wavelength range of 3.72-5 µm, which represents an unprecedentedly wide fractional bandwidth Δλ/λc of 30%. The cryogenically cooled Fabry-Perot filter exhibits an unrivaled high spectral resolution of 10 nm that far exceeds the optical requirement for MWIR hyperspectral imaging applications.

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Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry

Cited by 2 publications

References 18 publications

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

Cryogenic mid-wave infrared hyperspectral Fabry-Perot filter based on a tensile-strained single-layer subwavelength grating mirror

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