Penetration and Distribution of Thiocolchicoside through Human Skin: Comparison Between a Commercial Foam (Miotens®
              ) and a Drug Solution

Aguzzi, Carola; Rossi, Silvia; Bagnasco, Michela; Lanata, Luigi; Sandri, Giuseppina; Bona, Fosca; Ferrari, Franca; Caramella, Carla

doi:10.1208/s12249-008-9162-5

Cited by 20 publications

(9 citation statements)

References 11 publications

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“…TCC transdermal delivery, which has been studied by Artusi et al [ 20 ] , has the advantage of avoiding systemic side effects and improving patient compliance. In the form of nongreasy topical foams or gels, particularly when associated to skin penetration enhancers, [ 21 , 22 ] TCC may represent a well tolerated and effective formulation for the treatment and prevention of muscle contractures.…”

Section: Introductionmentioning

confidence: 99%

The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness

et al. 2017

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In professional road cyclists, the majority of overuse injuries affect the lower limbs and are mostly represented by contractures or muscle shortening, characterized by an increase of tone and stiffness and a variation of elasticity. Treatment and prevention of these specific conditions may include physical, supplementary, and pharmacologic support. The aim of this real-life study was to determine: first, the alterations of tone, stiffness, elasticity, and soreness of rectus femoris (RF) and biceps femoris (BF) in top class cyclists engaged in 3 multistage races, and second, whether any variable in the management of the athletes may affect the prevention and/or reduction of such alterations.Twenty-three professional cyclists competing in 3 international, cycling stage races were assessed. Athletes could receive, upon the approval of the medical staff, physical, dietary, and/or pharmacological management which could include treatments with topical over-the-counter myorelaxants to prevent and/or reduce muscle contractures. MyotonPro was used to daily measure tone, stiffness, and elasticity in RF and BF in relaxed and contracted state after every stage. In parallel, BF and RF soreness was also assessed with a Likert scale.All athletes received the same general massage management; none of them received dietary supplements; some of the athletes were treated with a topical myorelaxant thiocolchicoside (TCC 0.25%) foam 3 times daily. TCC was identified as the only variable able to affect these muscle parameters in the cyclists. Tone, stiffness (regardless of the state), and soreness significantly increased over time either in BF or RF in all athletes. In the group of athletes that used TCC (n = 11; TCC+) the increase in tone, stiffness, and soreness was significantly lower than in the group not receiving TCC (n = 12; No-TCC). Elasticity varied coherently with tone and stiffness.A very intense and protracted sport activity increases muscular tone, stiffness, and soreness over time. Topical TCC foam significantly attenuates these alterations and might represent an efficient strategy both to prevent and manage contractures and their consequences in professional cyclists as well in athletes from other disciplines involving similar workloads.

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Section: Introductionmentioning

confidence: 99%

The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness

et al. 2017

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“…In the case presented here, the results of patch tests on intact skin (negative in immediate reading) and open tests (positive only on inflamed skin) may indicate that epicutaneously applied TCD can induce an immediate reaction only when a damaged epidermal barrier is present. This finding is not surprising, considering the physicochemical properties of TCD-in particular its relatively high molecular weight of 563 daltons-which are not favorable to the drug permeating easily and rapidly through skin, as shown by Aguzzi et al on human excised full-thickness skin specimens (6). In the study by Aguzzi et al (6), in fact, TCD cutaneous amounts were very low or almost absent within the first hour of incubating the skin samples with TCD-containing products, including a 0.25% drug aqueous solution.…”

Section: Discussionmentioning

confidence: 83%

“…This finding is not surprising, considering the physicochemical properties of TCD-in particular its relatively high molecular weight of 563 daltons-which are not favorable to the drug permeating easily and rapidly through skin, as shown by Aguzzi et al on human excised full-thickness skin specimens (6). In the study by Aguzzi et al (6), in fact, TCD cutaneous amounts were very low or almost absent within the first hour of incubating the skin samples with TCD-containing products, including a 0.25% drug aqueous solution. Higher drug quantities were found after increasing the incubation time by using the same simple aqueous solution utilized for skin tests in the case presented here.…”

Section: Discussionmentioning

confidence: 83%

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Immediate and delayed contact hypersensitivity to thiocolchicoside

Mancuso¹

2018

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…A significant difference in the epidermal thickness was observed between the two protocols (p<0.05) (Supplementary Figure S8). Epidermal thickness increase likely results from tissue over-hydration that results from the dermis being in constant contact with the aqueous media reservoir in the Franz cell for 24 hrs [47–51]. CLSM results showed a higher presence of QDs in the mouse skin at the end of 6 and 24 hours using the petri dish exposure protocol compared to the Franz diffusion cell (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

Impact of Cosmetic Lotions on Nanoparticle Penetration through ex Vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study

et al. 2016

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Understanding the interactions of nanoparticles (NPs) with skin is important from a consumer and occupational health and safety perspective, as well as for the design of effective NP-based transdermal therapeutics. Despite intense efforts to elucidate the conditions that permit NP penetration, there remains a lack of translatable results from animal models to human skin. The objectives of this study are to investigate the impact of common skin lotions on NP penetration and to quantify penetration differences of quantum dot (QD) NPs between freshly excised human and mouse skin. QDs were mixed in 7 different vehicles, including 5 commercial skin lotions. These were topically applied to skin using two exposure methods; a petri dish protocol and a Franz diffusion cell protocol. QD presence in the skin was quantified using Confocal Laser Scanning Microscopy. Results show that the commercial vehicles can significantly impact QD penetration in both mouse and human skin. Lotions that contain alpha hydroxyl acids (AHA) facilitated NP penetration. Lower QD signal was observed in skin studied using a Franz cell. Freshly excised human skin was also studied immediately after the sub-cutaneous fat removal process, then after 24 hours rest ex vivo. Resting human skin 24 hours prior to QD exposure significantly reduced epidermal presence. This study exemplifies how application vehicles, skin processing and the exposure protocol can affect QD penetration results and the conclusions that maybe drawn between skin models.

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Penetration and Distribution of Thiocolchicoside through Human Skin: Comparison Between a Commercial Foam (Miotens® ) and a Drug Solution

Cited by 20 publications

References 11 publications

The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness

The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness

Immediate and delayed contact hypersensitivity to thiocolchicoside

Impact of Cosmetic Lotions on Nanoparticle Penetration through ex Vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study

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