PENENTUAN KEMURNIAN RADIOKIMIA 99mTc-MIBI DENGAN CEPAT DAN PRAKTIS MENGGUNAKAN METODA EKSTRAKSI

Maskur, Maskur; Lestari, Enny; Sarmini, Endang; Tahyan, Yayan; Putra, Amal Rezka; Kurniasih, Dede; Gunawan, Adang Hardi

doi:10.17146/urania.2017.23.1.3195

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accurate and early diagnosis is very important for the treatment step, otherwise, a wrong diagnosis always has negative consequences for the quality of life of the patients [3]. Nowadays, nuclear medicine has an important role in the diagnosis and treatment of many diseases [15][16][17]. The 99m Tc-based radiopharmaceuticals are ideal radiopharmaceuticals for diagnosis because 99m Tc radioisotope has a short half-life (6 hours).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography

Maskur

Lestari

Putra

et al. 2019

J. Pure App. Chem. Res.

Self Cite

View full text Add to dashboard Cite

The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of Thin Layer Chromatography (TLC) for radiochemical purity testing system that is faster and more practical. Two-system method of TLC for radiochemical purity testing uses mobile phase of methyl ethyl ketone indicated as system A and 0.9% sodium chloride solution indicated as system B. One-system method uses the mobile phase of a mixture solution of acetone and 0.9% sodium chloride. In this study, the determination of radiochemical purity of the one-system of TLC has been successfully developed using the Whatman-1 paper stationary phase and the mixture of mobile phase between acetone and 0.9% sodium chloride solution. The mobile phase of acetone: 0.9% sodium chloride with a ratio of 9:1 shows the most optimum results. This phase can separate 99mTc-DTPA (Rf = 0.4-0.6) from 99mTcO4- (Rf = 0.9-1.0) and 99mTcO2 (Rf = 0.0-0.1) as radiochemical impurities. This result shows that the one-system of TLC method can be used for radiochemical purity testing of 99mTc-DTPA radiopharmaceutical kits. This method can completely separate the product compound (99mTc-DTPA) from its impurities (99mTcO2 and 99mTcO4-).

show abstract

Section: Introductionmentioning

confidence: 99%

“…The 99m Tc-based radiopharmaceuticals are ideal radiopharmaceuticals for diagnosis because 99m Tc radioisotope has a short half-life (6 hours). In addition, the 99m Tc radioisotope is a pure gamma-ray transmitter (140 keV) which is ideal for producing good imaging using SPECT (Single Photon Emission Computed Tomography) devices [15][16].…”

Section: Introductionmentioning

confidence: 99%