Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model

Wu, Gen-Cheng; Mou, Min; Mo, Li-Qun; Liu, Li; Ren, Changhe; Chen, Ye; Zhou, Jun

doi:10.1016/j.jss.2014.12.018

Cited by 21 publications

(14 citation statements)

References 45 publications

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“…The protection of pharmacologic post-conditioning with PHC is limited by a “ceiling effect”. 27 Both VNS and treatment with acetylcholine or pseudocholinesterase are capable of suppressing LPS-induced systemic inflammatory response syndrome, as well decreasing release of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, and has been termed as “cholinergic anti-inflammatory pathway”. 28 Therefore, Wang et al hypothesized that PHC, an anticholinergic drug similar to atropine, suppresses the cholinergic anti-inflammatory pathway and abolishes pulmonary protective effects at higher concentrations.…”

Section: Resultsmentioning

confidence: 99%

Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride

Wang¹,

Gao²,

Ma³

2018

DDDT

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BackgroundPenehyclidine hydrochloride (PHC) is an anticholinergic drug manufactured in China. It is used widely in clinics as a reversal agent in cases of organic phosphorus poisoning and as a preanesthetic medication. Compared with other anticholinergic agents, PHC confers substantial advantages. Here, in this review, we focus on its important clinical effects for organic phosphorus poisoning, preanesthetic medication, and the protective effects on certain visceral organs.Materials and methodsOur bibliographic sources include the PubMed and China National Knowledge Infrastructure (CNKI) databases, updated in March 2018. To assess the data in detail, we used the search terms “penehyclidine hydrochloride,” “preanesthetic medication,” and “organic phosphorus.” Papers were restricted to those published in the English and Chinese languages, and to “paper” and “review” as the document type.ResultsPHC can effectively antagonize the symptoms of central and peripheral poisoning caused by organophosphorus poisoning. As a preanesthetic medication, it can not only effectively reduce mucus secretion and vascular infiltration but can also relax airway smooth muscles, dilate bronchioles in pulmonary conditions such as bronchiectasis, and increase pulmonary dynamic compliance. It can also prevent reflexive actions of the vagus nerve caused by excessive acetylcholine release such as abnormal airway contraction. Furthermore, it can strengthen sedation, bidirectionally regulate heart rate, and effectively inhibit respiratory secretions. In recent studies, PHC was shown to also have protective effects on various organs, such as the heart, lungs, brain, kidneys, intestines, and liver.ConclusionPHC has beneficial pharmacological properties used in the treatment of organophosphorus poisoning and as a preanesthetic medication for its few side effects. It also has protective effects on multiple organs, suggesting that PHC has extensive clinical application value which is worth further research. This review should be of help to those intending to research these topics further.

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Section: Resultsmentioning

confidence: 99%

Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride

Wang¹,

Gao²,

Ma³

2018

DDDT

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“…15,16 Many recent studies of PHC have proposed that it might be beneficial for LPS-induced ALI disorders. [22][23][24][25] Previous research demonstrated that preconditioning with PHC could reduce pulmonary microvascular endothelial injury from LPS-induced ALI. 22,23 Additional reports demonstrated that PHC could moderately reduce LPSinduced ALI through the inhibition of the mitogen-activated protein kinase (MAPK) family and NF-kappa B levels in rats.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 Additional reports demonstrated that PHC could moderately reduce LPSinduced ALI through the inhibition of the mitogen-activated protein kinase (MAPK) family and NF-kappa B levels in rats. 24,25 In addition to the aforementioned distinct biological changes, cell apoptosis is a generally acknowledged cause of LPS-induced ALI. 32,33 Different research methodologies demonstrated that ERS has a significant effect on the mechanisms of several lung disorders including LPS-induced ALI and lung fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The rats were then separated into 5 groups (n ¼ 6 per group): sham group, LPS group, LPS þ PHC (0.5 mg/kg) group, LPS þ PHC (1 mg/kg) group, and LPS þ PHC (2.5 mg/kg) group. [22][23][24][25] The rats used in this study were treated in accordance with the guidelines of the Institutional Animal Care and Use Committee of the Third Affiliated Hospital of Chongqing Medical University (2018010324).…”

Section: Ratsmentioning

confidence: 99%

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Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress

Yang

Qian-song

et al. 2020

Journal of Surgical Research

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“…An increasing number of studies have indicated that PHC exhibits anti-apoptotic, anti-inflammatory and anti-oxidative stress effects under organ dysfunction (16,32,33). A previous study demonstrated that PHC exerted anti-inflammatory properties and protective effects during ALI via the inhibition of the toll-like receptor 4 signaling pathway (34). Furthermore, Cao et al (35) confirmed that PHC alleviated cerebral injury by inhibiting the p38 mitogen-activated protein kinase (MAPK) and caspase-3.…”

Section: Discussionmentioning

confidence: 99%

Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway

Kong

Duan

et al. 2019

Exp Ther Med

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Acute lung injury (ALI) is a critical syndrome that is associated with high morbidity and mortality rates. The activation of the Fas/Fas ligand (FasL) signaling pathway may be an important pathophysiological mechanism during ALI development. Penehyclidine hydrochloride (PHC) has been revealed to exhibit anti-apoptotic properties and may attenuate the observed systemic inflammatory response. The present study was performed to elucidate the molecular mechanism of PHC in the regulation of the Fas/FasL signaling pathway in rats with ALI. An ALI rat model was constructed by inducing blunt chest trauma and hemorrhagic shock (T/HS), with PHC administration prior to or following T/HS. At 6 h following T/HS, blood samples and lung tissues were collected. Western blotting, arterial blood gas analysis, ELISA, hematoxylin and eosin staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining and biochemical indicator analysis were performed to determine the degree of lung injury and the key signaling pathways associated with lung damage. The results indicated that the administration of PHC following T/HS effectively attenuates lung injury by improving pulmonary oxygenation, decreasing histopathological damage, decreasing polymorphonuclear neutrophil count and decreasing Fas, FasL, caspase-8, caspase-3, tumor necrosis factor-α, interleukin (IL)-6 and IL-1β expression. The results indicated that PHC exhibits anti-apoptotic functions and exerts protective effects in ALI rats induced by T/HS, which may be attributed to the inhibition of the Fas/FasL signaling pathway.

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Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model

Cited by 21 publications

References 45 publications

Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride

Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride

Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress

Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway

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